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Abstract

The properties of proteins are determined not only by the sequence of amino-acid residues in the polypeptide chains, but also by the configuration of the chains—the way in which the chains are coiled or folded. It is probable that denaturation, the loss of some of the specific properties of a native protein, may in many cases be the result simply of a change in configuration of the polypeptide chains, without any change whatever in the sequence of amino-acid residues.

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Pauling, L., Corey, R.B. (1954). The Configuration of Polypeptide Chains in Proteins. In: Ƶechmeister, L. (eds) Fortschritte der Chemie Organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products / Progrés dans la Chimie des Substances Organiques Naturelles. Fortschritte der Chemie Organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products / Progrés dans la Chimie des Substances Organiques Naturelles, vol 11. Springer, Vienna. https://doi.org/10.1007/978-3-7091-8014-3_5

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