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Retrospective analysis of subretinal surgery

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The Macula

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Abstract

Background: Age-related macular degeneration (AMD) is the leading cause of legal blindness in people 50 years of age or older in the developed world. The treatment of AMD is still controversial and the search for a standard therapy for all forms of choroidal neovascularization (CNV) is on-going. Few randomized clinical trials are available regarding the surgical treatment of AMD. We performed a systematic review to determine the effectiveness of subretinal surgery for AMD and to summarize the reported results.

Methods: A MEDLINE search for the years 1992–2001 was conducted. Only original English- or German-language studies evaluating surgical interventions in AMD were assigned to one of four groups of surgical treatments. The main outcomes were improvement or deterioration of visual acuity (VA) after surgery.

Results: Sixty one studies met the inclusion criteria. The surgical procedures performed were removal of subfoveal choroidal neovascularization (CNV) (43%), macular translocation (25%), transplantation of pigment epithelium (10%) and removal of subretinal hemorrhage (23%). Thirty eight percent (range 0–87%) of all cases showed an improvement of VA and 26% (range 0–90%) a deterioration.

Conclusion: Compared to the natural course of AMD, subretinal surgery appears to be a promising method for the treatment of AMD. More randomized clinical studies are needed to draw unbiased conclusions and to allow for standard recommendations.

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Authors and Affiliations

  1. The Ludwig Boltzmann Institute of Retinology and Biomicroscopic Lasersurgery, Department of Ophthalmology, Rudolf Foundation Clinic, Juchgasse 25, A-1030, Vienna, Austria

    C. I. Falkner M.D. & S. Binder

  2. Department of Obstetrics and Gynecology, University of Vienna, Vienna, Austria

    H. Leitich

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  1. C. I. Falkner M.D.
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  2. S. Binder
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  3. H. Leitich
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Editors and Affiliations

  1. The Ludwig Boltzmann Institute of Retinology and Biomicroscopic Laser Surgery, Department of Ophthalmology, Rudolf Foundation Clinic, Vienna, Austria

    Susanne Binder

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© 2004 Springer-Verlag/Wien

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Falkner, C.I., Binder, S., Leitich, H. (2004). Retrospective analysis of subretinal surgery. In: Binder, S. (eds) The Macula. Springer, Vienna. https://doi.org/10.1007/978-3-7091-7985-7_11

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  • DOI: https://doi.org/10.1007/978-3-7091-7985-7_11

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-7987-1

  • Online ISBN: 978-3-7091-7985-7

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