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Substance P transmitter or regulator in spinal sensory mechanisms?

  • Chapter
Spinal Cord Monitoring

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Abstract

Evidence is reviewed which suggests multifunctional roles of substance P in spinal nociceptive pathways. There remains little challenge today to the notion that substance P is involved in excitatory regulation of nociception in the region of the first sensory synapse at spinal and brain stem levels. Criteria seem to be satisfied for substance P to qualify as a neurotrans-mitter. Actions of substance P on dorsal horn nociceptive neurones do seem to include relatively fast changes which can be consistent with those induced by a neurotransmitter (Otsuka and Yoshioka, 1993; Henry, 1993).

“The suggsted solutions for the difficulties disclosed by observation from ideas. Data (facts) and ideas (suggestions, possible solutions) thus form the two indespensable and correlative factors of all reflective activity....Mere facts or data are dead, as far as mind is concerned, unless they are used to suggest and test some idea, some way out of a difficulty. Ideas, on the other hand, are mere ideas, idle speculations, fantasies or dreams, unless they are used to guide new observations of and reflections upon actual situations, past, present or future.”

from: Of How We Think, 1933, John Dewey

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Authors and Affiliations

  1. Department of Physiology and Psychiatry, McGill University, Montreal, Canada

    J. L. Henry

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  1. J. L. Henry
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Editors and Affiliations

  1. Department of Clinical Neurophysiology, University Hospital, Uppsala University, Uppsala, Sweden

    Erik Stålberg M.D.

  2. Laboratory of Neuroanatomy, Department of Medical Cell Biology, Biomedical Centre, Uppsala University, Uppsala, Sweden

    Hari Shanker Sharma Ph.D.

  3. Laboratory of Neuropathology, Department of Pathology, University Hospital, Uppsala University, Uppsala, Sweden

    Yngve Olsson M.D.

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© 1998 Springer-Verlag Wien

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Henry, J.L. (1998). Substance P transmitter or regulator in spinal sensory mechanisms?. In: Stålberg, E., Sharma, H.S., Olsson, Y. (eds) Spinal Cord Monitoring. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6464-8_3

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  • DOI: https://doi.org/10.1007/978-3-7091-6464-8_3

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-7329-9

  • Online ISBN: 978-3-7091-6464-8

  • eBook Packages: Springer Book Archive

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