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Multiple system atrophy

  • Conference paper
Diagnosis and Treatment of Parkinson’s Disease — State of the Art

Part of the book series: Journal of Neural Transmission. Supplementa ((NEURAL SUPPL,volume 56))

Summary

Multiple system atrophy (MSA) is a degenerative central nervous system disease of unclear origin. Patients affected typically show symptoms attributable to the combined involvement of the extrapyramidal, pyramidal, cerebellar and autonomic nervous systems. At onset patients mostly see a doctor because of extrapyramidal or — more rarely — cerebellar symptoms. Evidence of autonomic nervous system involvement is often not apparent, at least to the neurologist, before the history is taken. In later stages, by contrast, involvement of all of the above systems is clinically detectable.

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References

  • Abbruzese G, Marchese R, Trompetto C (1997) Sensory and motor evoked potentials in multiple system atrophy: a comparative study with Parkinson’s disease. Mov Disord 12: 315–321

    Article  Google Scholar 

  • Bandmann O, Wenning GK, Quinn NP, Harding AE (1995) Arg296 to Cys296 polymorphism in exon 6 of cytochrome P-450-2D6 (CYP2D6) is not associated with multiple system atrophy. J Neurol Neurosurg Psychiatry 59: 557

    Article  PubMed  CAS  Google Scholar 

  • Bandmann O, Vaughan J, Holmans P, Marsden C, Wood N (1997) Multiple system atrophy is genetically distinct from identified hereditary causes of spinocerebellar degeneration. Neurology 9: 1598–1604

    Article  Google Scholar 

  • Bannister R, Mowbray J, Sidgwick A (1983) Genetic control of progressive autonomic failure: evidence for an association with an HLA antigen. Lancet 1: 1017

    Article  PubMed  CAS  Google Scholar 

  • Benecke R, Struemper P, Weiss H (1993) Electron transfer complexes I and IV of platelets are abnormal in Parkinson’s disease but normal in Parkinson-plus syndromes. Brain 116: 1451–1463

    Article  PubMed  Google Scholar 

  • Ben Shlomo Y, Wenning GK, Tison F, Quinn NP (1997) Survival of patients with pathologically proven multiple system atrophy: a meta-analysis. Neurology 48: 384–393

    Article  PubMed  CAS  Google Scholar 

  • Blin O, Desnuelle C, Rascol O, Borg M, Peyro Saint Paul H, Azulay J, Bille F, Figarella D, Coulom F, Peillissier J (1994) Mitochondrial respiratory failure in skeletal muscle from patients with Parkinson’s disease and multiple system atrophy. J Neurol Sci 125: 95–101

    Article  PubMed  CAS  Google Scholar 

  • Brooks D, Ibanez V, Sawle GC, Quinn N, Lees AJ, Bannister R, Marsden CD, Frackowiak RS (1990) Differing patterns of striatal 18F-dopa uptake in Parkinson’s disease, multiple system atrophy, and progressive supranuclear palsy. Ann Neurol 28: 547–555

    Article  PubMed  CAS  Google Scholar 

  • Cohen G (1994) The brain on fire? Ann Neurol 36: 333–334

    Article  PubMed  CAS  Google Scholar 

  • Conrad C, Andreadis A, Trojanowski JQ, Dickson DW, Kang D, Chen X, Wiederholt W, Hansen L, Masliah E, Thal LJ, Katzman R, Xia Y, Saitoh T (1997) Genetic evidence for the involvement of tau in progressive supranuclear palsy. Ann Neurol 41: 277–281

    Article  PubMed  CAS  Google Scholar 

  • Daniel S, Geddes J, Revesz T (1995) Glial cytoplasmic inclusions are not exclusive to multiple system atrophy. J Neurol Neurosurg Psychiatry 58: 262

    Article  PubMed  CAS  Google Scholar 

  • Dexter D, Carayon A, Javoy-Agid F, Agid Y, Wells F, Daniel S, Lees A, Jenner P, Marsden C (1991) Alterations in the levels of iron, ferritin and other trace metals in Parkinson’s disease and other neurodegenerative diseases affecting the basal ganglia. Mov Disord 114: 1953–1975

    Google Scholar 

  • Eardley I, Quinn NP, Fowler CJ, Kirby RS, Parkhouse HF, Marsden CD, Bannister R (1989): The value of urethral sphincter electromyography in the differential diagnosis of parkinsonism. Brit J Urol 64: 360–362

    Article  PubMed  CAS  Google Scholar 

  • Gilman S, Sima A, Junck L, Kluin K, Koeppe R, Lohman M, Little R (1996) Spinocerebellar ataxia type 1 with multiple system degeneration and glial cytoplasmic inclusions. Ann Neurol 39: 241–255

    Article  PubMed  CAS  Google Scholar 

  • Giunti P, Sweeney M, Harding A (1995) Detection of the Machado-Joseph disease/ spinocerebellar ataxia three trinucleotide repeat expansion in families with autosomal dominant motor disorders, including the Drew family of Walworth. Brain 118: 1077–1085

    Article  PubMed  Google Scholar 

  • Goldstein DS, Holmes C, Cannon RO, Eisenhofer G, Kopin IJ (1997) Sympathetic cardioneuropathy in dysautonomias. NEJM 336: 696–702

    Article  PubMed  CAS  Google Scholar 

  • Graham J, Oppenheimer D (1969): Orthostatic hypotension and nicotine sensitivity in a case of multiple system atrophy. J Neurol Neurosurg Psychiatry 32: 28–34

    Article  PubMed  CAS  Google Scholar 

  • Iwahashi K, Miyatake R, Tsuneoka Y, Matsuo Y, Ichikawa Y, Hosokawa K, Sato K, Hayabara T (1995) A novel cytochrome P-450IID6 (CYPIID6) mutant gene associated with multiple system atrophy. J Neurol Neurosurg Psychiatry 58: 263–264

    Article  PubMed  CAS  Google Scholar 

  • Lantos P, Papp M (1994) Cellular pathology of multiple system atrophy: a review. J Neurol Neurosurg Psychiatry 57: 129–133

    Article  PubMed  CAS  Google Scholar 

  • Leiguarda RC, Pramstaller PP, Merello M, Starkstein S, Lees AJ, Marsden CD (1997) Apraxia in Parkinson’s disease, progressive supranuclear palsy, multiple system atrophy and neuroleptic-induced parkinsonism, Brain 120: 75–90

    Article  PubMed  Google Scholar 

  • Nee L, Gomey M, Dambrosia J, Bale S, Eldridge R, Polinski R (1991) Enviromental-occupational risk factors and familial associations in multiple system atrophy: a preliminary investigation. Clin Auton Res 1: 9–13

    Article  PubMed  CAS  Google Scholar 

  • Olanow C (1993) A radical hypothesis for neurodegeneration. Trends Neurosci 16: 439–444

    Article  PubMed  CAS  Google Scholar 

  • Palace J, Chandiramani VA, Fowler CJ (1997): Value of sphincter electromyography in the diagnosis of multiple system atrophy. Muscle Nerve 20: 1396–1403

    Article  PubMed  CAS  Google Scholar 

  • Parkinson J (1817): An essay on the shaking palsy. Sherwood, Neely and Jones, London

    Google Scholar 

  • Pramstaller P, Wenning GK, Smith SJ, Beck RO, Quinn NP, Fowler CJ (1995) Nerve conduction studies, skeletal muscle EMG, and sphincter EMG in multiple system atrophy. JNNP 58: 618–621

    CAS  Google Scholar 

  • Quinn N (1989) Multiple system atrophy — the nature of the beast. J Neurol Neurosurg Psychiatry 52: 78–89

    Article  Google Scholar 

  • Quinn N (1994): Multiple system atrophy. In: Marsden C, Fahns S (eds) Movement disorders 3. Butterworth-Heinemann, London, S262–281

    Google Scholar 

  • Robbins TW, James M, Lange KW, Owen AM, Quinn NP, Marsden CD (1992) Cognitive performance in multiple system atrophy. Brain 115: 271–291

    Article  PubMed  Google Scholar 

  • Schapira AHV, Mann VM, Cooper JM, Dexter D, Daniel SE, Jenner P, Clark JB, Marsden CD (1990) Anatomic and disease specificity of NADH CoQl reductase (complex I) deficiency in Parkinson’s disease. J Neurochem 55: 2142–2145

    Article  PubMed  CAS  Google Scholar 

  • Schwarz J, Tatsch K, Arnold G, Gasser T, Trenkwalder C, Kirsch CM, Oertel WH (1992) 123I-iodobenzamide-SPECT predicts dopaminergic responsiveness in patients with de novo parkinsonism. Neurology 42: 556–561

    Article  PubMed  CAS  Google Scholar 

  • Schwarz J, Weis S, Kraft E, Tatsch K, Bandmann O, Mehraein P, Vogl T, Oertel W (1996) Signal changes on MRI and increases in reactive microgliosis, astrogliosis, and iron in the putamen of two patients with multiple system atrophy. J Neurol Neurosurg Psychiatry 60: 98–101

    Article  PubMed  CAS  Google Scholar 

  • Schwarz J, Kornhuber M, Bischoff C, Straube A (1997) Electromyography of the external anal sphincter in patients with Parkinson’s disease and multiple system atrophy: frequency of abnormal spontaneous activity and polyphasic motor unit potentials. Muscle Nerve 20: 1167–1172

    Article  PubMed  CAS  Google Scholar 

  • Shulman L, Weiner W (1997) Multiple system atrophy. In: Watts R, Kollers W (eds): Movement disorders: neurologic principles and practice. McGraw-Hill, New York, pp 297–304

    Google Scholar 

  • Shy G, Drager G (1960) A neurologic syndrome associated with orthostatic hypotension. Arch Neurol 2: 511–527

    Article  PubMed  CAS  Google Scholar 

  • Sian J, Dexter D, Lees A, Daniel S, Agid Y, Javoy-Agid F, Jenner P, Marsden C (1994a) Alterations in glutathione levels in Parkinson’s disease and other neurodegenerative disorders affecting the basal ganglia. Ann Neurol 36: 348–355

    Article  PubMed  CAS  Google Scholar 

  • Sian J, Dexter D, Lees A, Daniel S, Jenner P, Marsden C (1994b) Glutathione-related enzymes in brain in Parkinson’s disease. Ann Neurol 36: 356–361

    Article  PubMed  CAS  Google Scholar 

  • Stauffenberg V (1918): Zur Kenntnis des extrapyramidalen motorischen Systems und Mitteilung eines Falles von sog. “Atrophie olivo-pontocerebelleuse”, Z Gesamte Neurol Psychiatrie 39: 1–55

    Article  Google Scholar 

  • Swerdlow R, Parks JK, Miller SW, Tuttle JB, Trimmer PA, Sheehan JP, Bennett JP, Davis RE, Parker WD (1997) As in Parkinson’s disease, a bioenergetic defect transfers with mitochondrial DNA of patients with multisystem atrophy. Mov Disord 12 S1: 3

    Google Scholar 

  • Valldeoriola F, Valls-Sole J, Tolosa ES, Marti MJ (1995) Striated anal sphincter denervation in patients with progressive supranuclear palsy. Mov Disord 10: 550–555

    Article  PubMed  CAS  Google Scholar 

  • Wenning G, Ben Shlomo Y, Magalhaes M, Daniel S, Quinn N (1994a) Clinical features and history of multiple system atrophy. Brain 117: 835–845

    Article  PubMed  Google Scholar 

  • Wenning G, Jager R, Kendall B, Kingsley D, Daniel SE, Quinn NP (1994b) Is cranial computerized tomography useful in the diagnosis of multiple system atrophy? Mov Disord 9: 333–336

    Article  PubMed  CAS  Google Scholar 

  • Wenning G, Tison F, Elliott L, Quinn NP, Daniel SE (1996) Olivopontocerebellar pathology in multiple system atrophy. Mov Disord 11: 157–162

    Article  PubMed  CAS  Google Scholar 

  • Wood N (1997) Genes and parkinsonism. J Neurol Neurosurg Psychiatry 62: 305–309

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurology, Philipps-University Marburg, Rudolf-Bultmann-Strasse 8, D-35039, Marburg, Federal Republic of Germany

    Prof. Dr. W. H. Oertel & O. Bandmann

Authors
  1. Prof. Dr. W. H. Oertel
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  2. O. Bandmann
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Editor information

Editors and Affiliations

  1. Department of Neurology, St. Josef Hospital Ruhr University Bochum, Federal Republic of Germany

    H. Przuntek  & T. Müller  & 

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© 1999 Springer-Verlag Wien

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Oertel, W.H., Bandmann, O. (1999). Multiple system atrophy. In: Przuntek, H., Müller, T. (eds) Diagnosis and Treatment of Parkinson’s Disease — State of the Art. Journal of Neural Transmission. Supplementa, vol 56. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6360-3_9

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  • DOI: https://doi.org/10.1007/978-3-7091-6360-3_9

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-83275-2

  • Online ISBN: 978-3-7091-6360-3

  • eBook Packages: Springer Book Archive

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