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Free radical scavengers: chemical concepts and clinical relevance

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Diagnosis and Treatment of Parkinson’s Disease — State of the Art

Part of the book series: Journal of Neural Transmission. Supplementa ((NEURAL SUPPL,volume 56))

Summary

Free radicals are involved in the pathology of many CNS disorders, like Parkinson’s disease, Alzheimer’s disease, or stroke. This discovery lead to the development of many radical scavengers for the clinical treatment of neurodegenerative diseases. In this review, the different chemical concepts for free radical scavenging will be discussed: nitrons, thiols, iron chelators, phenols, and catechols. Especially catechols, like the naturally occurring flavonols, the synthetic drug nitecapone, or the endogenous catacholamines and their metabolites, are of great interest, as they combine iron chelating with radical scavenging activity. We present data on the radical scvenging activity of dopamine and apomorphine, which prevent lipid peroxidation in rat brain mitochondria and protect PC12 cells against H2O2-toxicity.

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Authors and Affiliations

  1. Biomedical Research CNS, Merck KGaA, Frankfurter Strasse 250, D-64271, Darmstadt, Federal Republic of Germany

    Dr. Michael Gassen

  2. Department of Pharmacology, Eve Topf and National Parkinson’s Foundation Centers for Neurodegenerative Diseases, Bruce Rappaport Family Research Institute, Faculty of Medicine, Technion, Israel

    M. B. H. Youdim

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  1. Dr. Michael Gassen
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Editors and Affiliations

  1. Department of Neurology, St. Josef Hospital Ruhr University Bochum, Federal Republic of Germany

    H. Przuntek  & T. Müller  & 

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Gassen, M., Youdim, M.B.H. (1999). Free radical scavengers: chemical concepts and clinical relevance. In: Przuntek, H., Müller, T. (eds) Diagnosis and Treatment of Parkinson’s Disease — State of the Art. Journal of Neural Transmission. Supplementa, vol 56. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6360-3_13

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  • DOI: https://doi.org/10.1007/978-3-7091-6360-3_13

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