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Role of anti-apoptotic Bcl-2 protein in spinal muscular atrophy

  • Conference paper
Advances in Research on Neurodegeneration

Summary

Apoptosis is an essential physiological cell death for selective elimination of cells, involved in a variety of biological events including morphogenesis, cell turn over and removal of harmful cells. Disruption of the regulation of apoptosis may result in various diseases, including cancer and autoimmune diseases both associated with inhibition of apoptosis and various degenerative disorders associated with enhancement of apoptosis, and therefore, apoptosis is an improtant theme in the medical field. Apoptosis is driven by a family of cysteine proteases, called caspases and regulated by a Bcl-2 family of proteins, which is the best characterized apoptosis regulators. The Bcl-2 family consists of anti-apoptotic and pro-apoptotic members, and some members are implicated in cancer and nuronal diseases.

Here, I overview the mechanism of how Bcl-2 family proteins regulate cell death, and how they are implicated in human diseases, particularly focusing on role of Bcl-2 in spinal muscular atropy.

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Authors and Affiliations

  1. Department of Medical Genetics, Osaka University Medical School, Biomedical Research Center, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan

    Prof. Y. Tsujimoto Ph.D.

Authors
  1. Prof. Y. Tsujimoto Ph.D.
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Editor information

Editors and Affiliations

  1. Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan

    Y. Mizuno

  2. Neurodegenerative Disorders Centre, Faculty of Medicine, University Hospital, Vancouver, B.C., Canada

    D. B. Calne

  3. Clinical Research, Schering AG, Berlin, Federal Republic of Germany

    R. Horowski

  4. Department of Neurology, University of Innsbruck, Austria

    W. Poewe

  5. Department of Psychiatry, University of Würzburg, Federal Republic of Germany

    P. Riederer

  6. Rappaport Family Institute for Research in the Medical Sciences, Haifa, Israel

    M. B. H. Youdim

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© 2000 Springer-Verlag Wien

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Tsujimoto, Y. (2000). Role of anti-apoptotic Bcl-2 protein in spinal muscular atrophy. In: Mizuno, Y., Calne, D.B., Horowski, R., Poewe, W., Riederer, P., Youdim, M.B.H. (eds) Advances in Research on Neurodegeneration. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6284-2_4

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  • DOI: https://doi.org/10.1007/978-3-7091-6284-2_4

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-7246-9

  • Online ISBN: 978-3-7091-6284-2

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