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Cytochalasans

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The Chemistry of Mycotoxins

Part of the book series: Progress in the Chemistry of Organic Natural Products ((POGRCHEM,volume 97))

Abstract

The cytochalasans are a group of structurally diverse fungal metabolites exhibiting a wide range of biological activities. Their name is derived from Greek (κύτος, kytos, cell; χάλασις, chalasis, relaxation) due to their most well-known effect, namely, the influence on actin filament networks in eukaryotic cells, which results in a deterioration of the dynamic processes involving the cytoskeleton formation. Together with some other biological properties, the cytochalasans represent a group of potential drug candidates, especially as anticancer agents.

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Authors and Affiliations

  1. Karlsruhe Institute of Technology (KIT), Institute of Organic Chemistry – Institute of Toxicology and Genetics, 76131, Karlsruhe, Germany

    Stefan Bräse

  2. Karlsruhe Institute of Technology (KIT), Institute of Organic Chemistry, 76131, Karlsruhe, Germany

    Franziska Gläser, Carsten S. Kramer, Stephanie Lindner, Anna M. Linsenmeier, Kye-Simeon Masters, Anne C. Meister, Bettina M. Ruff & Sabilla Zhong

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  1. Stefan Bräse
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Correspondence to Stefan Bräse .

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Bräse, S. et al. (2013). Cytochalasans. In: The Chemistry of Mycotoxins. Progress in the Chemistry of Organic Natural Products, vol 97. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1312-7_14

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