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Diagnostics, Lectin Detection and Cell–Cell Interactions

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Biomedical Applications of Peptide-, Glyco- and Glycopeptide Dendrimers, and Analogous Dendrimeric Structures

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Abstract

The Possible biological applications of dendrimers stem from their capacity to influence the cell–cell interactions. These interactions are mediated by branched glycoconjugates forming a structure called glycocalyx present on the cell surface. Glycopeptide dendrimers, which can mimic these structures, thus can be used for detection of important players involved in carbohydrate-mediated cell–cell interactions or signaling. Moreover, they can be used as artificial modulators of glycoconjugate-mediated signaling and thus influence important processes, such as immune response, inflammation or fertilization. These types of glycodendrimers are also under investigation as antitumor or antimicrobial therapeutic agents.

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Authors and Affiliations

  1. Department of Molecular Spectroscopy, Institute of Organic Chemistry and Biochemistry, AS CR, vvi, Prague, Czech Republic

    Jaroslav Šebestík

  2. Institute of Molecular Genetics AS CR, vvi, Prague, Czech Republic

    Milan Reiniš

  3. Laboratory of Glycoconjugates, Institute of Organic Chemistry and Biochemistry, AS CR, vvi, Prague, Czech Republic

    Jan Ježek

Authors
  1. Jaroslav Šebestík
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  2. Milan Reiniš
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  3. Jan Ježek
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Šebestík, J., Reiniš, M., Ježek, J. (2012). Diagnostics, Lectin Detection and Cell–Cell Interactions. In: Biomedical Applications of Peptide-, Glyco- and Glycopeptide Dendrimers, and Analogous Dendrimeric Structures. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1206-9_19

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