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Clinical Trials: Intracerebral Cell Therapy in Stroke Patients

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Cell-Based Therapies in Stroke

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Abstract

Successful experimental models of intracerebral cell transplantation to enhance neurological recovery from stroke have prompted the pursuit of early phase clinical trials. Published results of three completed studies report that intracerebral delivery of cell therapy is safe and feasible; one study of fetal porcine transplant was stopped prior to full completion due to adverse events. Though early phase clinical trials are primarily for safety and tolerability, all published studies included some measures of neurologic deficit and attempted to identify functional improvement on follow-up. Many individual patients demonstrated objective functional improvement; however, due to small sample size, any conclusions regarding the beneficial nature of intracerebral cell therapy must be reserved until the completion of later phase trials.

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Authors and Affiliations

  1. NYU Langone Medical Center, 530 First Ave, Suite 8R, New York, NY, 10016, USA

    Douglas Kondziolka M.D., M.Sc., FRCSC (Professor of Neurosurgery)

  2. Department of Neurosurgery, New York University, New York, USA

    Douglas Kondziolka M.D., M.Sc., FRCSC (Professor of Neurosurgery), Gillian Harrison B.S. & Lawrence Wechsler M.D.

  3. Departments of Neurological Surgery and Neurology, University of Pittsburgh, Pittsburgh, PA, 15213, USA

    Douglas Kondziolka M.D., M.Sc., FRCSC (Professor of Neurosurgery), Gillian Harrison B.S. & Lawrence Wechsler M.D.

Authors
  1. Douglas Kondziolka M.D., M.Sc., FRCSC
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  2. Gillian Harrison B.S.
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  3. Lawrence Wechsler M.D.
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Corresponding author

Correspondence to Douglas Kondziolka M.D., M.Sc., FRCSC .

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Editors and Affiliations

  1. , Institute of Clinical Medicine, University of Eastern Finland, Kuopio, 70210, Finland

    Jukka Jolkkonen

  2. School of Medicine, Division of MR Research, Johns Hopkins University, N Broadway 733, Baltimore, 21205, Maryland, USA

    Piotr Walczak

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Kondziolka, D., Harrison, G., Wechsler, L. (2013). Clinical Trials: Intracerebral Cell Therapy in Stroke Patients. In: Jolkkonen, J., Walczak, P. (eds) Cell-Based Therapies in Stroke. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1175-8_11

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  • DOI: https://doi.org/10.1007/978-3-7091-1175-8_11

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  • Online ISBN: 978-3-7091-1175-8

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