Abstract
Hyperbaric oxygenation (HBO) therapy has been reported to improve neurological recovery following spinal cord injury (SCI). In the present study, we examined whether multiple HBO expands the therapeutic window for acute SCI. Single HBO (2.8 ATA, 1 hour) treatment was used at 30 minutes, 3 hours, and 6 hours following SCI, and serial HBO treatment (once daily for 1 week) at 6 hours and 24 hours post-injury. Mild SCI was induced by adjusting the height for a weight drop insult (10 g) to 6.25 mm above the exposed spinal cord. The group of animals receiving a single HBO intervention beginning at 30 minutes and 3 hours, or serial HBO treatment starting at 6 hours following the injury had a significantly better neurological recovery than animals with SCI only. The results of this study demonstrate that multiple HBO expands the therapeutic window for acute SCI to 6 hours after injury, further that serial HBO administration is superior to single HBO therapy.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Yanagawa Y, Marcillo A, Garcia-Rojas R, Loor KE, Dietrich WD (2001) Influence of posttraumatic hypoxia on behavioral recovery and histopathological outcome following moderate spinal cord injury in rats. J Neurotrauma 18(6): 635–644
McVicar JP, Luce JM (1986) Management of spinal cord injury in the critical care setting. Crit Care Clin 2(4): 747–758
Yanagawa Y, Marcillo A, Garcia-Rojas R, Loor KE, Dietrich WD (2001) Influence of posttraumatic hypoxia on behavioral recovery and histopathological outcome following moderate spinal cord injury in rats. J Neurotrauma 18(6): 635–644
Kraus JF, Franti CE, Riggins RS (1975) Incidence of traumatic spinal cord lesions. J Chronic Dis 28: 471–492
Gamache FW Jr, Myers RA, Ducker TB, Cowley RA (1981) The clinical application of hyperbaric oxygen therapy in spinal cord injury: a preliminary report. Surg Neurol 15(2): 85–87
Rockswold SB, Rockswold GL, Vargo JM, Erickson CA, Sutton RL, Bergman TA, Biros MH (2001) Effects of hyperbaric oxygenation therapy on cerebral metabolism and intracranial pressure in severely brain injured patients. J Neurosurg 94(3): 403–411
Mink RB, Dutka AJ (1995) Hyperbaric oxygen after global cerebral ischemia in rabbits reduces brain vascular permeability and blood flow. Stroke 26(12): 2307–2312
Sunami K, Takeda Y, Hashimoto M, Hirakawa M (2000) Hyperbaric oxygen reduces infarct volume in rats by increasing oxygen supply to the ischemic periphery. Crit Care Med 28(8): 2831–2836
Veltkamp R, Warner DS, Domoki F, Brinkhous AD, Toole JF, Busija DW (2000) Hyperbaric oxygen decreases infarct size and behavioral deficit after transient focal cerebral ischemia in rats. Brain Res 853(1): 68–73
Badr AE, Yin W, Mychaskiw G, Zhang JH (2001) Dual effect of HBO on cerebral infarction in MCAO rats. Am J Physiol Regul Integr Comp Physiol 280(3): R766–R770
Sukoff M, Jain KK (1999) Hyperbaric oxygen therapy in neurosurgery. Textbook of hyperbaric medicine. Hogrefe & Huber Publishers, pp 351–371
Yanagawa Y, Marcillo A, Garcia-Rojas R, Loor KE, Dietrich WD (2001) Influence of posttraumatic hypoxia on behavioral recovery and histopathological outcome following moderate spinal cord injury in rats. J Neurotrauma 18(6): 635–644
Tator CH, Fehlings MG (1991) Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms. J Neurosurg 75(1): 15–26
Osterholm JL (1974) The pathophysiological response to spinal cord injury. The current status of related research. J Neurosurg 40(1): 5–33
Holbach KH, Wassmann H, Linke D (1977) The use of hyperbaric oxygenation in the treatment of spinal cord lesions. Eur Neurol 16(1–6): 213–221
Lee MR, Sakatani K, Young W (1993) Interaction of hypoxia and hypothermia on dorsal column conduction in adult rat spinal cord in vitro. Exp Neurol 119(1): 140–145
Kelly DL Jr, Lassiter KR, Vongsvivut A, Smith JM (1972) Effects of hyperbaric oxygenation and tissue oxygen studies in experimental paraplegia. J Neurosurg 36(4): 425–429
Narayana PA, Kudrle WA, Liu SJ, Charnov JH, Butler BD, Harris JH Jr (1991) Magnetic resonance imaging of hyperbaric oxygen treated rats with spinal cord injury: preliminary studies. Magn Reson Imaging 9(3): 423–428
Haapaniemi T, Nylander G, Kanje M, Dahlin L (1998) Hyperbaric oxygen treatment enhances regeneration of the rat sciatic nerve. Exp Neurol 149(2): 433–438
Higgins AC, Pearlstein RD, Mullen JB, Nashold BS Jr (1981) Effects of hyperbaric oxygen therapy on long-tract neuronal conduction in the acute phase of spinal cord injury. J Neurosurg 55(4): 501–510
Murakami N, Horinouchi T, Sakurai M, Ejima Y, Matsukawa S, Kato M, Tabayashi K (2001) Hyperbaric oxygen therapy given 30 minutes after spinal cord ischemia attenuates selective motor neuron death in rabbits. Crit Care Med 29(4): 814–818
Gamache FW Jr, Myers RA, Ducker TB, Cowley RA (1981) The clinical application of hyperbaric oxygen therapy in spinal cord injury: a preliminary report. Surg Neurol 15(2): 85–87
Sukoff MH (2001) Effects of hyperbaric oxygenation. J Neurosurg 95(3): 544–546
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2003 Springer-Verlag Wien
About this paper
Cite this paper
Huang, L., Mehta, M.P., Eichhorn, J.H., Nanda, A., Zhang, J.H. (2003). Multiple hyperbaric oxygenation (HBO) expands the therapeutic window in acute spinal cord injury in rats. In: Kuroiwa, T., et al. Brain Edema XII. Acta Neurochirurgica Supplements, vol 86. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0651-8_89
Download citation
DOI: https://doi.org/10.1007/978-3-7091-0651-8_89
Publisher Name: Springer, Vienna
Print ISBN: 978-3-7091-7220-9
Online ISBN: 978-3-7091-0651-8
eBook Packages: Springer Book Archive