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Burn scar treatment

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Handbook of Burns

Abstract

Scar formation is considered as an integrative part of the complex and dynamic process of normal physiological wound healing to restore skin integrity following injury and is referred as to the maturation phase. This phase is dominated by fibroblasts. The pivotal feature of this process is the synthesis, deposition, and remodeling of collagen, the major structural substance of connective tissue. The collagen deposition in normal wound healing peaks by the third week after injury. Collagen remodeling is characterized by a (balanced) continuous synthesis and degradation of collagen and is observed already early during the wound healing process. The degradation of wound collagen is controlled by a variety of enzymes such as collagenases (e. g. MMP-1) derived from granulocytes, macrophages, keratinocytes and fibroblasts. On the other hand the expression and activity of collagenases is tightly controlled by cytokines.

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Authors and Affiliations

  1. Burns Unit, Wound Healing Unit, Lapeyronie Hospital, Montpellier University Hospital Montpellier, 391 Avenue Doyen Giraud, 34 255, Montpellier Cedex, France

    Luc Teot MD, PhD, Sami Otman, Antonio Brancati & Rainer Mittermayr

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  1. Luc Teot MD, PhD
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  2. Sami Otman
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  3. Antonio Brancati
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  4. Rainer Mittermayr
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Correspondence to Luc Teot MD, PhD .

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Editors and Affiliations

  1. Plastische, Aesthetische und Rekonstruktive Chirurgie, Landesklinikum Wiener Neustadt, Wiener Neustadt, Austria

    Lars-Peter Kamolz M.D., M.Sc

  2. Sunnybrook Health Sciences Centre, Department of Surgery, Division of Plastic Surgery, University of Toronto, Sunnybrook Research Institute, Toronto, ON, Canada

    Marc G. Jeschke M.D., Ph.D.

  3. Universitätsklinikum Erlangen, Plastisch- und Handchirurgische Klinik, Erlangen, Germany

    Raymund E. Horch M.D., Ph.D.

  4. Evangelische Elisabeth Klinik Krankenhausbetriebs gGmbH, Berlin, Germany

    Markus Küntscher M.D., Ph.D.

  5. Prednosta Kliniky popálenin, a rekonstrukcní chirurgie, FN Brno, Czech Republic

    Pavel Brychta M.D., Ph.D., C.Sc.

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Teot, L., Otman, S., Brancati, A., Mittermayr, R. (2012). Burn scar treatment. In: Kamolz, LP., Jeschke, M.G., Horch, R.E., Küntscher, M., Brychta, P. (eds) Handbook of Burns. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0315-9_5

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