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Grundlagen der Theophyllintherapie: Durchführung und Bewertung von Konzentrationsbestimmungen im Serum

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Konzentrationsmessungen von Pharmaka, Bedeutung für Klinik und Praxis

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Zusammenfassung

Theophyllin (1,3-Dimethylxanthin) wurde als ein wirkungsbestimmender Inhaltsstoff der Blätter des Teestrauchs Ende des 19. Jahrhunderts isoliert und seine Struktur in der ersten Dekade des 20. Jahrhunderts aufgeklärt. Mit der Herstellung des Theophyllin-Aethylendiamin-Komplexes (Aminophyllin) wurde die Substanz infolge dessen besserer Löslichkeit intravenös einsetzbar. Die Indikationen ergeben sich aus dem Wirkungsprofil, das dem anderer in der Natur vorkommender Methylxanthine (Koffein, Theobromin) qualitativ entspricht:

  • Stimulation von Zns-Funktionen (vegetativ, motorisch, sensorisch und psychisch)

  • positiv inotrope und chronotrope Wirkung am Herzen

  • Relaxation der glatten Muskulatur (Atemwege, Gefäße, Intestinaltrakt und Urogenitalsystem)

  • diuretischer Effekt

  • Wechselwirkung mit anderen Pharmaka (so additive oder potenzierende Effekte zu Analgetika und Spasmolytika).

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Literaturverzeichnis

  • Aranda, J. V., Sitar, D. S., Parsons, W. D., Loughnan, P. M, Neims, A. H.: Pharmacokinetic Aspects of Theophylline in Premature Newborns. N. Engl. J. Med. 295, 413 (1976).

    Article  PubMed  CAS  Google Scholar 

  • Beavo, J. A., Rogers, N. L, Crofford, O. B., Baird, C. E., Hardman, J. G., Sutherland, E. W., Newman, E. V.: Effects of Phosphodiesterase Inhibitors on Cyclic Amp Levels and on Lipolysis. Ann. N. Y. Acad. Sci. 185, 129 (1971).

    Article  PubMed  CAS  Google Scholar 

  • Borner, K., Staib, A. H, Schuppan, D, Molz, K. H., Lissner, R, Lichey, J.: Analytical Reliability of Methods to Determine Theophylline in Serum or Plasma. In: Methods in Clinical Pharmacology (eds., Rietbrock, N., Neuhaus, G., Woodcock, B. G.). Vieweg-Verlag, Braunschweig (im Druck).

    Google Scholar 

  • Bory, C., Baltassat, P., Porthault, M., Bethenod, M., Frederich, A., Aranda, J. V.: Metabolism of theophylline to caffeine in premature newborn infants. J. Pediatr. 94, 988 (1979).

    Article  PubMed  CAS  Google Scholar 

  • Eichler, O.: Kaffee und Coffein. 2. Aufl. Springer-Verlag, Berlin, Heidelberg, New York, 1976.

    Book  Google Scholar 

  • Ellis, E. F., Koysooko, R., Levy, G.: Pharmacokinetics of Theophylline in Children with Asthma. Pediatrics 58, 542 (1976).

    PubMed  CAS  Google Scholar 

  • Ellis, E. F.: Asthma in Childhood: Clinical Pharmacology of Theophylline in Asthmatic Children. New Directions in Asthma (ed. M. Stein) Americ. Coll. Chest Physic. Park Ridge, Ill., 1975, 317–323.

    Google Scholar 

  • Eppel, M. L., Mackay, A., Oliver, J. S., Ramsay, L. E.: Factors Influencing the Dose of Oral Aminophylline. Brit. J. Clin. Pharmacol. 8, 834p (1979).

    Google Scholar 

  • Forth, W., Henschler, D., Rummel, W.: Allgemeine und spezielle Pharmakologie und Toxikologie. Bibl. Inst. Mannheim — Wien — Zürich 1975.

    Google Scholar 

  • Gal, P., Jusko, W. J., Yurchak, A. M., Franklin, B. A.: Theophylline Dispositon in Obesity. Clin. Pharmacol. Ther. 23, 438 (1978).

    PubMed  CAS  Google Scholar 

  • Giacoia, G., Jusko, W. J., Menke, J., Koup, J. R.: Theophylline Pharmacokinetics in Premature Infants with Apnea. J. Pediatr. 89, 829 (1976).

    Article  PubMed  CAS  Google Scholar 

  • Heinz, N., Rietbrock, N.: Relationship between dose and Plasma Level of Digoxin and Patient Characteristics. Europ. J. Clin. Pharmacol. 15, 109 (1979).

    Article  CAS  Google Scholar 

  • Hendeles, L, Weinberger, M., Johnson, G.: Monitoring Serum Theophylline Levels. Clin. Pharmacokin. 3, 294 (1978).

    Article  CAS  Google Scholar 

  • Hendeles, L, Weinberger, M., Wyatt, R.: Guide to Oral Theophylline Therapy for the Treatment of Chronic Asthma. Am. J. Dis. Child 132, 876 (1978).

    PubMed  CAS  Google Scholar 

  • Hunts, S. N., Jusko, W. J., Yurchak, A. M.: Effect of Smoking on Theophylline Disposition. Clin. Pharmacol. Ther. 19, 546 (1976).

    Google Scholar 

  • Jenne, J. W., Nagasawa, H., McHUGH, R., Mac Donald, F., Wyse, E.: Decreased theophylline half-life in cigarette smokers. Life Sciences 17, 195, 1975.

    Article  PubMed  CAS  Google Scholar 

  • Jenne, J. W., Nagasawa, H. T., Thompson, R. D.: Relationship of Urinary Metabolites of Theophylline to Serum Theophylline Levels. Clin. Pharmacol. Ther. 19, 375 (1976).

    PubMed  CAS  Google Scholar 

  • Jusko, W. J, Koup, J. R., Vance, J. W., Schentag, J.J., Kuritzky, P.: Intravenous Theophylline Therapy: Nomogram Guidelines. Ann. Intern. Med. 86, 400 (1977).

    Article  PubMed  CAS  Google Scholar 

  • Jusko, W. J., Schentag, J. J., Clark, J. H., Gardner, M., Yurchak, A. M.: Enhanced Biotransformation of Theophylline in Marihuana and Tobacco Smokers. Clin. Pharmacol. Ther. 24, 406 (1978).

    CAS  Google Scholar 

  • Kadlec, G. J., Le Thanh HA, Jarboe, C. H., Richards, D., Karibo, J. M.: Theophylline Half-Live in Infants and Young Children. Ann. Allergy 40, 303 (1978).

    PubMed  CAS  Google Scholar 

  • Kappas, A., Alvares, A. P., Anderson, K. E., Pantuck, E. J., Pantuck, C. B., Chang, R., Conney, A. H.: Effect of Charcoal-Broiled Beef on Antipyrine and Theophylline Metabolism. Clin. Pharmacol. Ther. 23, 445 (1978).

    PubMed  CAS  Google Scholar 

  • Kellermann, G., Luythen-Kellermann, M.: Benzo (a) pyrene Metabolism and Plasma Elimination Rates of Phenacetin, Acetanilide and Theophylline in Man. Pharmacology 17, 191 (1978).

    Article  PubMed  CAS  Google Scholar 

  • Klotz, U.: Klinische Pharmakokinetik. G. Fischer Verlag, Stuttgart — New York 1979.

    Google Scholar 

  • Koysooko, R., Ellis, E. F., Levy, G.: Relationship between theophylline Concentration in Plasma and Saliva of Man. Clin. Pharmacol. Ther. 15, 454 (1974).

    PubMed  CAS  Google Scholar 

  • Lawyer, C. H., Keppel, J., Bardana, E. J.: Theophylline in Liver Disease. N. Engl. J. Med. 297, 112 (1977).

    Article  Google Scholar 

  • Levy, G., Ellis, E. F., Koysooko, R.: Indirect Plasma-Theophylline Monitoring in Asthmatic Children by Determination of Theophylline Concentration in Saliva. Pediatrics 53, 873 (1974).

    PubMed  CAS  Google Scholar 

  • Lohmann, S., Miech, R. P.: Theophylline Metabolism by the Rat Liver Microsomal System. J. Pharmacol. exp. ther. 196, 213 (1976).

    PubMed  CAS  Google Scholar 

  • Loughnan, P. M, Sitar, D. S., Ogilvie, R. I., Eisen, A., Fox, Z., Neims, A. H.: Pharmacokinetic Analysis of the Disposition of Intravenous Theophylline in Young Children. Pediatrics 88, 874 (1976).

    Article  CAS  Google Scholar 

  • Mangione, A., Imhoff, T. E., Lee, R. V., Shum, L. Y., Jusko, W. J.: Pharmacokinetics of Theophylline in Hepatic Disease. Chest 73, 616 (1978).

    Article  PubMed  CAS  Google Scholar 

  • Miech, R. P., Lohman, S. M.: Metabolism and Pharmacodynamics of Theophylline. New Directions in Asthma (ed. M. Stein) Americ. Coll. Chest Physic. Park Ridge, Ill. 1975, 377–390.

    Google Scholar 

  • Mitenko, P. A., Ogilvie, R. I.: Rapidly Achieved Plasma Concentration Plateaus, with Observations on Theophylline Kinetics. Clin. Pharmacol. Ther. 13, 329 (1972).

    PubMed  CAS  Google Scholar 

  • Mitenko, P. A., Ogilvie, R. I.: Pharmacokinetics of Intravenous Theophylline. Clin. Pharmacol. Ther. 14, 509 (1973).

    PubMed  CAS  Google Scholar 

  • Nielsen-Kudsk, F., Magnussen, I., Jakobsen, P.: Pharmacokinetics of Theophylline in Ten Elderly Patients. Acta pharmacol. et toxicol 42, 226 (1978).

    Article  CAS  Google Scholar 

  • Ogilvie, R. I.: Clinical Pharmacokinetics of Theophylline. Clin. Pharmacokin. 3, 267 (1978).

    Article  CAS  Google Scholar 

  • Pfeifer, H.J., Greenblatt, D.J., Friedman, P.: Effects of three Antibiotics on Theophylline Kinetics. Clin. Pharmacol. Ther. 26, 36 (1979).

    PubMed  CAS  Google Scholar 

  • Piafsky, K. M., Ogilvie, R. I.: Drug Therapy. Dosage of Theophylline in Bronchial Asthma. N. Engl. J. Med. 292, 1218 (1975).

    Article  PubMed  CAS  Google Scholar 

  • Piafsky, K. M., Sitar, D. S., Rangno, R. E., Ogilvie, R. I.: Theophylline Kinetics in Acute Pulmonary Edema. Clin. Pharmacol. Ther. 21, 310 (1977).

    PubMed  CAS  Google Scholar 

  • Piafsky, K. M., Sitar, D. S., Rangno, R. E., Ogilvie, R. I.: Theophylline Disposition in Patients with Hepatic Cirrhosis. N. Engl. J. Med. 296, 1495 (1977).

    Article  PubMed  CAS  Google Scholar 

  • Powell, J. R., Thiercelin, J. F., Vozeh, S., Sansom, L., Riegelman, S.: The Influence of Cigarette Smoking and Sex on Theophylline Disposition. Am. Rev. Resp. Dis. 116, 17 (1977).

    PubMed  CAS  Google Scholar 

  • Rietbrock, N.: Wissenswertes über Pharmakokinetik. Kurse ärztl. Fortbil. 29, 483 (1979).

    Google Scholar 

  • Schack, J. A., Waxler, S. H.: An Ultraviolet Spectrophotometric Method for the Determination of Theophylline and Theobromine in Blood and Tissues. J. Pharmacol, exp. ther. 97, 283 (1949).

    CAS  Google Scholar 

  • Simons, K.J., Simons, F. E., Briggs, C. J., LO, L.: Theophylline Protein Binding in Humans. J. Pharmac. Sci. 68, 252 (1979).

    Article  CAS  Google Scholar 

  • Slotfeld, M. L., Johnson, C. E., Grambau, G., Weg, J. G.: Reliability of Theophylline Clearance in Determining Chronic Oral Dosage Regimens. Am. J. Hosp. Pharm. 37, 66 (1977).

    Google Scholar 

  • Spangler, D. L., Kalof, D. D., Bloom, F. L., Wittig, H. J.: Theophylline Bioavailability Following Oral Administration of Six Sustained-Release preparations. Ann. Allergy 40, 6 (1978).

    PubMed  CAS  Google Scholar 

  • Staib, A., H., Schuppan, D., Lissner, R., Zilly, W., v. Bomhard, G., Richter, E.: Theophylline plasma Pharmacokinetics and Urinary Metabolite Pattern in Patients with Liver Diseases. Internat. Sympos. Methods in Clinical Pharmacology, Frankfurt/M., 1979. In: Methods in Clinical Pharmacology, (eds Rietbrock, N., Neuhaus, G., Woodcock, B. G.) Vieweg-Verlag, Braunschweig (im Druck).

    Google Scholar 

  • Waxler, S. H., Schack, J. A.: Administration of Aminophylline (Theophylline Ethylenediamine). J. Amer. Med. Ass. 143, 736 (1950).

    Article  CAS  Google Scholar 

  • Weinberger, M., Hendeles, L., Bighley, L.: The Relation of Product Formulation to Absorption of Oral Theophylline. N. Engl. J. Med. 299, 852 (1978).

    Article  PubMed  CAS  Google Scholar 

  • Zilly, W., Staib, A. H., Epping, J., Schuppan, D.: Der Einfluß von Rifampicin auf die Pharmakokinetik von Theophyllin. — 86. Tagung der Deutschen Gesellschaft für innere Medizin, Wiesbaden 13.–15. April 1980, Vortrag 180.

    Google Scholar 

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  1. Klinische Pharmakologie, Klinikum der J. W. G.-Universität Frankfurt/M., Theodor-Stern-Kai 7, D-6000, Frankfurt 70, Deutschland

    Priv.-Doz. Dr. sc. med. A. H. Staib

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  1. Priv.-Doz. Dr. sc. med. A. H. Staib
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K. Hierholzer N. Rietbrock

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© 1980 Springer Fachmedien Wiesbaden

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Staib, A.H. (1980). Grundlagen der Theophyllintherapie: Durchführung und Bewertung von Konzentrationsbestimmungen im Serum. In: Hierholzer, K., Rietbrock, N. (eds) Konzentrationsmessungen von Pharmaka, Bedeutung für Klinik und Praxis. Vieweg+Teubner Verlag, Wiesbaden. https://doi.org/10.1007/978-3-663-14065-8_6

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  • DOI: https://doi.org/10.1007/978-3-663-14065-8_6

  • Publisher Name: Vieweg+Teubner Verlag, Wiesbaden

  • Print ISBN: 978-3-528-07904-8

  • Online ISBN: 978-3-663-14065-8

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