Abstract
Triglyceride-rich lipoproteins are thought to be associated with an accelerated development of arteriosclerosis. The influence of an oral fat load of 100 g fat on blood lipids and lipoproteins has been investigated. 12 hours after the last food intake the triglycerides in the serum and in the lipoproteins VLDL, LDL and HDL were higher than in control persons. Cholesterol was higher in the VLDL but lower in the HDL. Following fat loading these differences to the control group were even more marked. In patients with coronary heart disease a greater increase and a more delayed decrease in the serum triglycerides were obvserved. 6 hours after the fat intake there was an increased concentration of triglycerides in the VLDL and in the LDL. The cholesterol concentration in the VLDL was equally elevated, though in the HDL it had declined. The results suggest that in patients with coronary heart disease there are also disturbances in postprandial lipid metabolism which acquire pathogenic significance in regard to the development of arteriosclerosis.
Zusammenfassung
Triglyzeridreiche Lipoproteine sind in Zusammenhang mit beschleunigter Arterioskleroseentwicklung gebracht worden. Bei Patienten mit koronarer Herzkrankheit (KHK) wurde der Einfluß einer oralen Fettbelastung mit 100 g Fett auf die Lipide und die Lipoproteine im Blut untersucht. 12 Stunden nach der letzten Nahrungsaufnahme waren die Trig lyzeride im Serum und in den Lipoproteinen Very low density lipoproteins (VLDL), Low density lipoproteins (LDL) und High density lipoproteins (HDL) höher als bei den Kontrollpersonen, das Cholesterin war in den VLDL höher, in den HDL aber niedriger. Nach Fettbelastung wurden die Unterschiede zu den Kontrollpersonen deutlicher. Bei den Patienten mit KHK wurde ein verstärkter Anstieg und ein verzögerter Abfall der Serumtriglyzeride beobachtet. Sechs Stunden nach der Fetteinnahme war die Triglyzeridkonzentration in den VLDL und in den LDL angestiegen, die Cholesterinkonzentration in den VLDL war ebenfalls angestiegen, in den HDL jedoch abgefallen. Die Ergebnisse weisen darauf hin, daß bei Patienten mit KHK Störungen im postprandialen Lipoproteinstoffwechsel bestehen, denen bei der Arterioskleroseentwicklung eine pathogenetische Bedeutung zukommt.
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© 1993 Springer Fachmedien Wiesbaden
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Ditschuneit, H.H., Flechtner-Mors, M., Knispel, D., Voisard, R., Ditschuneit, H. (1993). Lipoprotein levels following oral fat intake in patients with coronary heart disease. In: Heinle, H., Schulte, H., Schaefer, H.E. (eds) Diätetik und Arteriosklerose. Vieweg+Teubner Verlag, Wiesbaden. https://doi.org/10.1007/978-3-663-01942-8_14
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DOI: https://doi.org/10.1007/978-3-663-01942-8_14
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