Abstract
Ciprofloxacin is a new fluoroquinolone derivative with a broad antibacterial spectrum. It is considerably more active than nalidixic acid against Enterobacteriaceae and is also active against organisms resistant to a wide range of antimicrobial agents of other groups such as beta-lactam antibiotics and aminoglycosides (1–3). Ciprofloxacin is well absorbed when administered orally. After a 500 mg single dose the peak level reaches about 2.5 mg/1 1 1/2 h after administration. Between 30% and 40% of the dose is recovered in urine during the 24 h following drug administration (3–6).
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References
Van Caekenberthe, D. L., Stefaan, R., Pattyn, S. R.: In vitro activity of ciprofloxacin compared with those of other new fluorinated piperazinyl-substitutued quinoline derivatives. Antimicrobial Agents and Chemotherapy 1984, 25: 518–521.
Wise, R., Andrews, J. M., Edwards, L. J.: In vitro activity of Bay 0 9867, a new quinoline derivative, compared with that of other antimicrobial agents. Antimicrobial Agents and Chemotherapy 1983, 23: 559–564.
King, A., Shannon, K., Phillips, I.: The in vitro activities of enoxacin and ofloxacin compared with that of ciprofloxacin. Journal of Antimicrobial Chemotherapy 1985, 15: 551–558.
Gonzalez, M. A., Uribe, F., Duran, Moisen, S., Pichardo Fuster, A., Selen, A., Welling, P. G., Painter, B.: Multiple dose pharmacokinetics and safety of ciprofloxacin in normal volunteers. Antimicrobial Agents and Chemotherapy 1984, 26: 741–744.
Höffken, G., Lode, H., Prinzing, C., Borner, K., Koeppe, P.: Pharmacokinetics of ciprofloxacin after oral and parenteral administration. Antimicrobial Agents and Chemotherapy 1985, 27: 375–379.
Crump, B., Wise, R., Dent, J.: Pharmacokinetics and tissue penetration of ciprofloxacin. Antimicrobial Agents and Chemotherapy 1983, 23: 784–786.
Guibert, J., Acar, J. F., Justin, C., Kitzis, M. D.: Evaluation clinique du céfotaxime à différents dosages thérapeutiques dans les infections urinaires. Nouvelle Presse Médicale 1981, 10: 625–627.
Guibert, J., Coppens, H., Yvelin, C.: Evaluation clinique du céfotiam dans les infections urinaires de l’adulte. Pathologie et Biologie 1982, 30: 353–356.
Guibert, J., Acar, J. F., Miegi, M.: Evaluation clinique de l’azthréonam dans les infections urinaires sévères. Pathologie et Biologie 1984, 32: 446–449.
Guibert, J., Acar, J. F., Destrée, D., Bryskier, A.: Evaluation clinique de la cefmenoxime dans les infections urinaires et prostatiques. Pathologie et Biologie 1985, 33: 330–334.
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© 1986 Springer Fachmedien Wiesbaden
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Guibert, J., Destrée, D., Konopka, C., Acar, J. (1986). Ciprofloxacin in the Treatment of Urinary Tract Infection due to Enterobacteria. In: Neu, H.C., Reeves, D.S. (eds) Ciprofloxacin. Current Topics in Infectious Diseases and Clinical Microbiology, vol 1. Vieweg+Teubner Verlag, Wiesbaden. https://doi.org/10.1007/978-3-663-01930-5_34
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DOI: https://doi.org/10.1007/978-3-663-01930-5_34
Publisher Name: Vieweg+Teubner Verlag, Wiesbaden
Print ISBN: 978-3-663-01931-2
Online ISBN: 978-3-663-01930-5
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