Zusammenfassung
Wenn die Behandlung maligner Erkrankungen zu einer Langzeitremission bzw. zu einer Heilung führt, können Langzeitnebenwirkungen wie die Neurotoxizität die Lebensqualität des Patienten wesentlich beeinträchtigen. Die Pflegenden können durch gute Beobachtung und Beratung dazu beitragen, dass neurologische Symptome frühzeitig erkannt, medizinische Maßnahmen dadurch rechtzeitig eingeleitet und so lang anhaltende Neurotoxizitäten vermieden oder vermindert werden. Kommt es dennoch zu irreversiblen neurologischen Schäden, können gezielte pflegerische Interventionen und Zusammenarbeit mit anderen Diziplinen, z. B. Physiotherapie, Ergotherapie, den Patienten die Aufrechterhaltung von möglichst vielen Aktivitäten ermöglichen
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Literatur
Christie LA et al. (2012) Impaired Cognitive Function and Hippocampal Neurogenesis following Cancer Chemotherapie. Clin Cancer Res;18: 1954–65
Hershman DL et al. (2014) Prevention and Management of Chemotherapy-Induced Peripheral Neuropathy in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline. J Clin Oncol 32(18):1941-67. doi: 10.1200/JCO.2013.54.0914
Hershman DL et al. (2013) Randomized double-blind placebo-controlled trial of acetyl-L-carnitine for the prevention of taxane-induced neuropathy in women undergoing adjuvant breast cancer therapy. J Clin Oncol 10; 31(20): 2627–33
Koeppen S (2009) Tumortherapiebedingte Neuropathie. Onkologe 15: 142–149
Loprinzi CL et al. (2014) Phase III randomized, placebo-controlled, double-blind study of intravenous calcium and magnesium to prevent oxaliplatin-induced sensory neurotoxicity (N08CB/Alliance). J Clin Oncol 32: 997–1005
Lavoie Smith EM et al. (2008) The total neuropathy score: a tool for measuring chemotherapy-induced peripehral neuropathy. Oncol Nurs Forum 35, 1: 96–102
Miltenburg NC, Boogerd W (2014) Chemotherapy-induced neuropathy: A comprehensive survey. Cancer Treat Rev 40: 872–82
Paice J (2009) Clinical Challenges: Chemotherapy-Induced Peripheral Neuropathy Seminars in Oncology Nursing, Vol 25, No 2, Suppl 1: S8–S19
Smith EM et al. (2013) Effect of duloxetine on pain, function, and quality of life among patients with chemotherapy-induced painful peripheral neuropathy: a randomized clinical trial. JAMA. Apr 3; 309(13): 1359-67. doi: 10.1001/jama.2013.2813
Tofthagen C et al. (2013) Chemotherapy-Induced Peripheral Neuropathy:An Algorithm to Guide Nursing Management Clinical Journal of Oncology Nursing Volume 17; 2: 138–144
Vardy J et al. (2014) Cognitive function and fatigue after diagnosis of colorectal cancer Ann. Onc 25: 2404–2412
Visovsky C et al. (2007) Putting evidence into practice: evidence based interventions for chemotherapy-induced peripheral neuropathy. Clin J Onc Nurs 11; 6: 901–913
Von Ah D (2015) Cognitive Changes Associated with Cancer Treatment: State of the Science. CJON Vol 19, Number 1: 1–10
Wickham R (2007) Chemotherapy induced peripher neuropathy – a review and implications for oncology nursing practice. Clin J Oncol Nurs 11; 3: 361–376
Wolf S et al. (2008) Chemotherapy-induced peripheral neuropathy: Prevention and treatment stategies. Eur J Cancer 44: 1507–1515
Weiterführende Literatur
Albers JW et al. (2014). Interventions for preventing neuropathy caused by cisplatin and related compounds. Cochrane Database of Systematic Reviews (Online), March 2014 CD005228. DOI: 10.1002/14651858.CD005228.pub4
Bender C, Thelen B (2013) Cancer and Cognitive Changes: The complexity of the Problem. Seminars in Oncology Nursing 29; 4: 232–237
Cavaletti G (2013) The chemotherapy-induced peripheral neuropathy outcome measures standardization study: from consensus to the first validity and reliability findings. Annals of Oncology 24: 454–462, 2013 doi:10.1093/annonc/mds329
Dietrich J et al. (2008) Clinical patterns and biological correlates of cognitive dysfunction associated with cancer therapy. Oncologist; 13: 1285–1295
Frisina RD et al. (2016) Comprehensive Audiometric Analysis of Hearing Impairment and Tinnitus After Cisplatin-BasedChemotherapy in Survivors of Adult-Onset Cancer. J Clin Oncol. 10; 34(23): 2712–20
Grapp M, Argstatter H et al. (2014) Music therapy for chronic tinnitus: variability of tinnitus pitch in the course of therapy. J Am Acad Audiol 25(4): 335-42. doi: 10.3766/jaaa.25.4.5
Smith EM et al (2008), The Total Neuropathy Score: A Tool for Measuring Chemotherapy-Induced Peripheral Neuropathy. Oncology nursing Forum 35; 1: 96–102
Tzatha E, DeAngelis LM (2016) Chemotherapy-Induced Peripheral Neuropathy. Oncology 30(3): 240–4
Vasquez S (2014) Chemotherapy induced peripheral neuropathy: the modified total neuropathy score in clinical practice. Irish Journal of Medical Science 183; 1: 53–5
Internetadresse
Function Assessment of Chronic Illness Therapy: www.facit.org (Fragebogen zur Erfassung von Neurotoxizität, Fragebogen zur Erfassung der kognitiven Funktion)
Patienten Broschüre
www.tzb.de – Broschüre »Chemobrain«. Merk -und Konzentrationsstörungen bei Tumorpatienten
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Oechsle, K., Margulies, A. (2017). Neurotoxizität. In: Margulies, A., Kroner, T., Gaisser, A., Bachmann-Mettler, I. (eds) Onkologische Krankenpflege. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-53955-2_17
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