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Pediatric Germ Cell Tumors

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Pathology and Biology of Human Germ Cell Tumors

Abstract

Germ cell tumors in the pediatric age group conform a heterogeneous collection of neoplastic entities whose common denominator is their origin in progenitor germ cells. The three major types include teratoma, embryonal carcinoma/yolk sac tumor, and seminoma/dysgerminoma. Their common extragonadal locations are consistent with migratory pathways of primitive germ cells during the embryo–fetal development and tend to predominate in younger patients, while their appearance in ovaries and testes, occurring across the pediatric age spectrum, reflects the abundance of germ cells in those organs. Their fascinating and large morphologic spectrum reveals the wide potentiality characteristic of germ cells.

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Authors and Affiliations

  1. Lucile Packard Children’s Hospital Stanford, Stanford University Medical Center, 300 Pasteur Drive, Rm H1501K, Stanford, CA, 94305, USA

    Eduardo Zambrano MD, MSc

  2. Department of Pathology, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA, 94305, USA

    Danielle Vargas De Stefano MD

  3. Children’s Hospital of Pittsburgh of UPMC. University of Pittsburgh School of Medicine. Department of Pathology B256, One Children’s Hospital Drive, Pittsburgh, PA, 15224, USA

    Miguel Reyes-Múgica MD (Chief of Pathology and Head of Laboratories)

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  1. Eduardo Zambrano MD, MSc
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  2. Danielle Vargas De Stefano MD
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  3. Miguel Reyes-Múgica MD
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Correspondence to Miguel Reyes-Múgica MD .

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Editors and Affiliations

  1. Departamento de Anatomía Patológica, Universidad de Granada Facultad de Medicina, Granada, Spain

    Francisco F. Nogales

  2. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA

    Rafael E. Jimenez

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Zambrano, E., De Stefano, D.V., Reyes-Múgica, M. (2017). Pediatric Germ Cell Tumors. In: Nogales, F., Jimenez, R. (eds) Pathology and Biology of Human Germ Cell Tumors. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-53775-6_10

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  • DOI: https://doi.org/10.1007/978-3-662-53775-6_10

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