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Cancer Stem Cells

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Molecular Radio-Oncology

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 198))

Abstract

The cancer stem cell model in solid tumors has evolved significantly from the early paradigm shifting work highlighting parallels between the stem cell hierarchy in hematologic malignancies and solid tumors. Putative stem cells can dedifferentiated, be induced by context, and be the result of accumulated genetic mutations. The simple hypothesis that stem cell therapies will overcome the minority of cells that lead to recurrence has evolved with it. Nevertheless, the body of evidence that this field is clinically relevant in patients and patient care has grown with the complexity of the hypotheses, and numerous clinical strategies to target these cells have been identified. Herein we review this progress and highlight the work still outstanding.

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Acknowledgements

Dr. Woodward is supported by the National Institutes of Health R01CA138239-01 and 1R01CA180061-01 and The State of Texas Grant for Rare and Aggressive Breast Cancer Research Program.

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Authors and Affiliations

  1. Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA

    Wendy A. Woodward

  2. Princess Margaret Cancer Centre, Ontario Cancer Insitute, Toronto, ON, M5G 2M9, Canada

    Richard P. Hill

  3. Department of Medical Biophysics, University of Toronto, Toronto, ON, M5G 2M9, Canada

    Richard P. Hill

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  1. Wendy A. Woodward
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Correspondence to Wendy A. Woodward .

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  1. Department of Radiation Oncology, University of Technology, Dresden, Germany

    Michael Baumann

  2. Klinik und Poliklinik für Stra, Medizinische Fakultät und Univ, Dresden, Germany

    Mechthild Krause

  3. University of Technology, Dresden, Germany

    Nils Cordes

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Woodward, W.A., Hill, R.P. (2016). Cancer Stem Cells. In: Baumann, M., Krause, M., Cordes, N. (eds) Molecular Radio-Oncology. Recent Results in Cancer Research, vol 198. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-49651-0_2

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