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DNA Repair

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Molecular Radio-Oncology

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 198))

Abstract

Cellular chromosomal DNA is the principal target through which ionising radiation exerts it diverse biological effects. This chapter summarises the relevant DNA damage signalling and repair pathways used by normal and tumour cells in response to irradiation. Strategies for tumour radiosensitisation are reviewed which exploit tumour-specific DNA repair deficiencies or signalling pathway addictions, with a special focus on growth factor signalling, PARP, cancer stem cells, cell cycle checkpoints and DNA replication. This chapter concludes with a discussion of DNA repair-related candidate biomarkers of tumour response which are of crucial importance for implementing precision medicine in radiation oncology.

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Authors and Affiliations

  1. Laboratory of Radiobiology and Experimental Radio-Oncology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany

    Kerstin Borgmann, Sabrina Köcher, Malte Kriegs, Wael Yassin Mansour, Ann Christin Parplys, Thorsten Rieckmann & Kai Rothkamm

  2. Department of Otorhinolaryngology and Head and Neck Surgery, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany

    Thorsten Rieckmann

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  1. Kerstin Borgmann
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  2. Sabrina Köcher
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  1. Department of Radiation Oncology, University of Technology, Dresden, Germany

    Michael Baumann

  2. Klinik und Poliklinik für Stra, Medizinische Fakultät und Univ, Dresden, Germany

    Mechthild Krause

  3. University of Technology, Dresden, Germany

    Nils Cordes

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Borgmann, K. et al. (2016). DNA Repair. In: Baumann, M., Krause, M., Cordes, N. (eds) Molecular Radio-Oncology. Recent Results in Cancer Research, vol 198. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-49651-0_1

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