Zusammenfassung
Die Inzidenz von GallenwegskarzinomGallenwegskarzinomen steigt im höheren Lebensalter stark an, so dass sich auch bei über 70- und 80-jährigen Patienten immer öfter die Frage nach einer chirurgischen Therapie stellt. Allerdings erfordert dies meist eine große Leberoperation, so dass eine sorgfältige Abklärung obligat ist. Hierzu sollte neben kardiopulmonaler Diagnostik auch eine Leberfunktionsmessung mit Volumetrie gehören. Insbesondere bei eingeschränkter Funktionsreserve der Leber sollten im hohen Alter soweit wie möglich parenchymsparende Resektionen bzw. präkonditionierende Maßnahmen (z. B. Pfortaderembolisation) erwogen werden. Wenn sich keine Kontraindikationen ergeben, sollten auch geeignete alte Patienten reseziert werden, da sie in ähnlichem Maße wie junge Patienten von einer kurativen Operation profitieren.
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Literatur
Bridgewater J, Galle PR, Khan SA et al (2014) Guidelines for the diagnosis and management of intrahepatic cholangiocarcinoma. J hepatol 60(6):1268–1289
Chen T, Wang H, Wang H, Song Y, Li X, Wang J (2013) POSSUM and P-POSSUM as predictors of postoperative morbidity and mortality in patients undergoing hepato-biliary-pancreatic surgery: a meta-analysis. Ann Surg Oncol 20(8):2501–2510
Enkhbold C, Morine Y, Utsunomiya T, Imura S, Ikemoto T et al (2015) Dysfunction of liver regeneration in aged liver after partial hepatectomy. J Gastroenterol Hepatol 30(7):1217–1224
Guglielmi A, Ruzzenente A, Campagnaro T et al (2013) Patterns and prognostic significance of lymph node dissection for surgical treatment of perihilar and intrahepatic cholangiocarcinoma. J gastrointest surg 17(11):1917–1928
Hellmann S, Schafmayer C, Hinz S, Schniewind B, Tepel J et al (2010) Evaluation of the POSSUM score in surgical treatment of cholangiocarcinoma. Hepatogastroenterology 57(99-100):403–408
Jara M, Reese T, Malinowski M, Valle E, Seehofer D et al (2015). Reductions in post-hepatectomy liver failure and related mortality after implementation of the LiMAx algorithm in preoperative work-up: a single-centre analysis of 1170 hepatectomies of one or more segments. HPB (Oxford) 17(7):651–658. 17: 651–8
Kou T, Kanai M, Ikezawa K, Ajiki T, Tsukamoto T et al (2014) Comparative outcomes of elderly and non-elderly patients receiving first-line palliative chemotherapy for advanced biliary tract cancer. J Gastroenterol Hepatol 29:403–408
Lederer A, Seehofer D, Schirmeier A, Levasseur S, Stockmann M et al (2013) Postoperative bile leakage inhibits liver regeneration after 70 % hepatectomy in rats. J Invest Surg 26(1):36–45
Miyazaki M, Ito H, Nakagawa K, Ambiru S, Shimizu H et al (1998) Aggressive surgical approaches to hilar cholangiocarcinoma: hepatic or local resection? Surgery 123:131–136
Ono Y, Kawachi S, Hayashida T et al (2011) The influence of donor age on liver regeneration and hepatic progenitor cell populations. Surgery 150(2):154–161
Phan K, An VV, Ha H, Phan S, Lam V, Pleass H (2015) Hepatic resection for malignant liver tumours in the elderly: a systematic review and meta-analysis. ANZ J Surg 85(11):815–822 doi: 10.1111/ans.13211
Preston SD, Southall AR, Nel M, Das SK (2008) Geriatric surgery is about disease, not age. J R Soc Med 101(8):409–415
Robert Koch-Institut, www.rki.de
Russolillo N, Ratti F, Viganò L, Langella S, Cipriani F et al (2015) The Influence of aging on hepatic regeneration and early outcome after portal vein occlusion: a case-control study. Ann Surg Oncol 22(12):4046–4051, doi: 10.1245/s10434-015-4478-3, Epub 2015 Mar 11
Sanchez-Hidalgo JM, Naranjo A, Ciria R, Ranchal I, Aguilar-Melero P et al (2012) Impact of age on liver regeneration response to injury after partial hepatectomy in a rat model. J Surg Res; 175(1):e1–9
Schiergens TS, Stielow C, Schreiber S, Hornuss C, Jauch KW et al (2014) Liver resection in the elderly: significance of comorbidities and blood loss. J Gastrointest Surg 18(6):1161–1170
Schnapauff D, Denecke T, Grieser C, Collettini F, Seehofer D et al (2012) Computed tomography-guided interstitial HDR brachytherapy (CT-HDRBT) of the liver in patients with irresectable intrahepatic cholangiocarcinoma. Cardiovasc Intervent Radiol 35:581–587
Seehofer D, Brunner T, Wege H (2015) Aktuelle Therapiekonzepte für lokale Cholangiokarzinome. Onkologe 21(11):1054–1063
Seehofer D, Stockmann M, Schirmeier A, Nüssler AK, Cho SY et al (2007) Intraabdominal bacterial infections significantly alter regeneration and function of the liver in a rat model of major hepatectomy. Langenbecks Arch Surg 392(3):273–284
Shindoh J, Truty MJ, Aloia TA, Curley SA, Zimmitti G et al (2012) Kinetic growth rate after portal vein embolization predicts posthepatectomy outcomes: toward zero liver-related mortality in patients with colorectal liver metastases and small future liver remnant. J Am Coll Surg 216(2):201–209
Sotiropoulos GC, Lang H, Molmenti EP, Kaiser GM, Paul A, Broelsch CE (2009) Partial or complete mesohepatectomy combined with resection of the hilar bifurcation in cases of Klatskin tumors: a reasonable strategy? Am J Surg 198(2):297–298
Stockmann M, Lock JF, Malinowski M, Niehues SM, Seehofer D, Neuhaus P (2010) The LiMAx test: a new liver function test for predicting postoperative outcome in liver surgery. HPB (Oxford) 12(2):139–146
Stockmann M, Lock JF, Riecke B, Heyne K, Martus P et al (2009a). Prediction of postoperative outcome after hepatectomy with a new bedside test for maximal liver function capacity. Ann Surg 250(1):119–125
Stockmann M, Malinowski M, Lock JF, Seehofer D, Neuhaus P (2009b). Factors influencing the indocyanine green (ICG) test: additional impact of acute cholestasis. Hepatogastroenterology 56(91-92):734–738
Takahashi Y, Ebata T, Yokoyama Y, Igami T, Sugawara G, Nagino M (2013) Surgical treatment of perihilar cholangiocarcinoma in octogenarians: a single center experience. J Hepatobiliary Pancreat Sci 20(3):324–331
Tyson GL, Ilyas JA, Duan Z, Green LK, Younes M et al (2014) Secular trends in the incidence of cholangiocarcinoma in the USA and the impact of misclassification. Dig Dis Sci 59(12):3103–3110
Yeh CN, Jan YY, Chen MF (2004) Influence of age on surgical treatment of peripheral cholangiocarcinoma. Am J Surg 187:559–563
Yoshizumi T, Taketomi A, Uchiyama H et al (2008) Graft size, donor age, and patient status are the indicators of early graft function after living donor liver transplantation. Liver Transpl 14(7):1007–1013
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Seehofer, D., Neuhaus, P. (2016). Chirurgie von Gallenwegstumoren bei alten Patienten. In: Keck, T., Hopt, U. (eds) Onkologische Chirurgie bei alten Patienten. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-48712-9_17
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