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Dendrimer-Based Nanodevices as Contrast Agents for MR Imaging Applications

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Advances in Nanotheranostics I

Part of the book series: Springer Series in Biomaterials Science and Engineering ((SSBSE,volume 6))

Abstract

Dendrimers possess unique three-dimensional architectures, highly branched macromolecular characteristics, and abundant terminal functional groups. These properties of dendrimers afford their uses as a versatile nanoplatform to design multifunctional nanodevices for various biomedical applications, especially for magnetic resonance (MR) imaging of different biological systems. The periphery of dendrimers can be linked with targeting ligands and imaging agents, while the unique dendrimer interior and surface functionality render their uses to form dendrimer-entrapped metal nanoparticles (NPs) or dendrimer-assembled magnetic iron oxide NPs. The formed dendrimer-based contrast agents can be used for various MR imaging applications, including T1-weighted MR, T2-weighted MR, MR/computed tomography, MR/fluorescence imaging of blood pool, animal organs, and tumors. In particular, this chapter mainly introduces some recent advances of dendrimer-based contrast agents for MR imaging of cancer.

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Acknowledgments

This research is financially supported by the National Natural Science Foundation of China (21273032), the Sino-German Center for Research Promotion (GZ899), the Ph.D. Programs Foundation of Ministry of Education of China (20130075110004), and the Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of High Learning.

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Authors and Affiliations

  1. State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai, 201620, People’s Republic of China

    Wenjie Sun & Xiangyang Shi

  2. College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620, People’s Republic of China

    Wenjie Sun, Jingchao Li, Mingwu Shen & Xiangyang Shi

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  1. Wenjie Sun
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  2. Jingchao Li
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  3. Mingwu Shen
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  4. Xiangyang Shi
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Correspondence to Mingwu Shen or Xiangyang Shi .

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  1. Department of Biomedical Engineering, College of Engineering, Peking University, Beijing, China

    Zhifei Dai

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Sun, W., Li, J., Shen, M., Shi, X. (2016). Dendrimer-Based Nanodevices as Contrast Agents for MR Imaging Applications. In: Dai, Z. (eds) Advances in Nanotheranostics I. Springer Series in Biomaterials Science and Engineering, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-48544-6_8

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  • DOI: https://doi.org/10.1007/978-3-662-48544-6_8

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