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Organic Dye-Loaded Nanoparticles for Imaging-Guided Cancer Therapy

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Advances in Nanotheranostics I

Part of the book series: Springer Series in Biomaterials Science and Engineering ((SSBSE,volume 6))

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Abstract

Recently, organic dye-based imaging-guided cancer therapy has attracted much attention in the field of cancer nanomedicine. As a small molecular compound, organic dye has an exact molecular weight and chemical structure. It can be not only used as fluorescence and photoacoustic imaging probes but also applied as therapeutic agents for photodynamic and photothermal therapy. Functionalized with the different delivery nanomaterials, organic dyes exhibit a long halftime and high tumor targeting and promoted stability. In this chapter, we review the development of organic dyes for cancer imaging and therapy applications in decades and illustrate the use of functional nanomaterials as organic dye delivery systems for enhancing their stability and tumor targeting, which show the bright prospects and challenges toward organic dye-based imaging-guided cancer therapy.

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References

  1. Yuan A, Wu J, Tang X, Zhao L, Xu F, Hu Y (2013) Application of near-infrared dyes for tumor imaging, photothermal, and photodynamic therapies. J Pharm Sci 102:6–28

    Article  Google Scholar 

  2. Luo S, Zhang E, Su Y, Cheng T, Shi C (2011) A review of NIR dyes in cancer targeting and imaging. Biomaterials 32:7127–7138

    Article  Google Scholar 

  3. Frenette M, Hatamimoslehabadi M, Bellinger-Buckley S, Laoui S, La J, Bag S, Mallidi S, Hasan T, Bouma B, Yelleswarapu C, Rochford J (2014) Shining light on the dark side of imaging: excited state absorption enhancement of a Bis-styryl BODIPY photoacoustic contrast agent. J Am Chem Soc 136:15853–15856

    Article  Google Scholar 

  4. Frangioni JV (2003) In vivo near-infrared fluorescence imaging. Curr Opin Chem Biol 7:626–634

    Article  Google Scholar 

  5. Wang LV, Hu S (2012) Photoacoustic tomography: in vivo imaging from organelles to organs. Science 335:1458–1462

    Article  Google Scholar 

  6. Sheng Z, Song L, Zheng J, Hu D, He M, Zheng M, Gao G, Gong P, Zhang P, Ma Y, Cai L (2013) Protein-assisted fabrication of nano-reduced graphene oxide for combined in vivo photoacoustic imaging and photothermal therapy. Biomaterials 34:5236–5243

    Article  Google Scholar 

  7. Sheng Z, Hu D, Xue M, He M, Gong P, Cai L (2013) Indocyanine green nanoparticles for theranostic applications. Nano-Micro Lett 5:145–150

    Article  Google Scholar 

  8. Mitsunaga M, Nakajima T, Sano K, Kramer-Marek G, Choyke PL, Kobayashi H (2012) Immediate in vivo target-specific cancer cell death after near infrared photoimmunotherapy. BMC Cancer 12:345

    Article  Google Scholar 

  9. Jiang C, Cheng H, Yuan A, Tang X, Wu J, Hu Y (2014) Hydrophobic IR780 encapsulated in biodegradable human serum albumin nanoparticles for photothermal and photodynamic therapy. Acta Biomater. doi:10.1016/j.actbio.2014.11.041

    Google Scholar 

  10. Cheng C, He WW, Gong H, Wang C, Chen Q, Cheng ZP, Liu Z (2013) PEGylated micelle nanoparticles encapsulating a non-fluorescent near-infrared organic dye as a safe and highly-effective photothermal agent for in vivo cancer therapy. Adv Fun Mater 23:5893–5902

    Article  Google Scholar 

  11. Wong BS, Yoong SL, Jagusiak A, Panczyk T, Ho HK, Ang WH, Pastorin G (2013) Carbon nanotubes for delivery of small molecule drugs. Adv Drug Deliv Rev 65:1964–2015

    Article  Google Scholar 

  12. Wu X, Zhang F, Chen R, Zheng W, Yang X (2014) Recent advances in imaging-guided interventions for prostate cancers. Cancer Lett 349:114–119

    Article  Google Scholar 

  13. Vahrmeijer AL, Hutteman M, van der Vorst JR, van de Velde CJ, Frangioni JV (2013) Image-guided cancer surgery using near-infrared fluorescence. Nat Rev Clin Oncol 10:507–518

    Article  Google Scholar 

  14. Rahmathulla G, Recinos PF, Kamian K, Mohammadi AM, Ahluwalia MS, Barnett GH (2014) MRI-guided laser interstitial thermal therapy in neuro-oncology: a review of its current clinical applications. Oncology 87:67–82

    Article  Google Scholar 

  15. van Dam GM, Themelis G, Crane LM, Harlaar NJ, Pleijhuis RG, Kelder W, Sarantopoulos A, de Jong JS, Arts HJ, van der Zee AG, Bart J, Low PS, Ntziachristos V (2011) Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results. Nat Med 17:1315–1319

    Article  Google Scholar 

  16. Mohs AM, Mancini MC, Singhal S, Provenzale JM, Leyland-Jones B, Wang MD, Nie S (2010) Hand-held spectroscopic device for in vivo and intraoperative tumor detection: contrast enhancement, detection sensitivity, and tissue penetration. Anal Chem 82:9058–9065

    Article  Google Scholar 

  17. Madajewski B, Judy BF, Mouchli A, Kapoor V, Holt D, Wang MD, Nie S, Singhal S (2012) Intraoperative near-infrared imaging of surgical wounds after tumor resections can detect residual disease. Clin Cancer Res 18:5741–5751

    Article  Google Scholar 

  18. Mitsunaga M, Ogawa M, Kosaka N, Rosenblum LT, Choyke PL, Kobayashi H (2011) Cancer cell-selective in vivo near infrared photoimmunotherapy targeting specific membrane molecules. Nat Med 17:1685–1691

    Article  Google Scholar 

  19. Nakajima T, Sano K, Choyke PL, Kobayashi H (2013) Improving the efficacy of photoimmunotherapy (PIT) using a cocktail of antibody conjugates in a multiple antigen tumor model. Theranostics 3:357–365

    Article  Google Scholar 

  20. Mitsunaga M, Nakajima T, Sano K, Choyke PL, Kobayashi H (2012) Near-infrared theranostic photoimmunotherapy (PIT): repeated exposure of light enhances the effect of immunoconjugate. Bioconjug Chem 23:604–609

    Article  Google Scholar 

  21. Nakajima T, Sano K, Mitsunaga M, Choyke PL, Kobayashi H (2012) Real-time monitoring of in vivo acute necrotic cancer cell death induced by near infrared photoimmunotherapy using fluorescence lifetime imaging. Cancer Res 72:4622–4628

    Article  Google Scholar 

  22. Dorozhkin SV, Epple M (2002) Biological and medical significance of calcium phosphates. Angew Chem Int Ed Engl 41:3130–3146

    Article  Google Scholar 

  23. Altinoğlu EI, Russin TJ, Kaiser JM, Barth BM, Eklund PC, Kester M, Adair JH (2008) Near-infrared emitting fluorophore-doped calcium phosphate nanoparticles for in vivo imaging of human breast cancer. ACS Nano 2:2075–2084

    Article  Google Scholar 

  24. Barth BM, Sharma R, Altinoğlu EI, Morgan TT, Shanmugavelandy SS, Kaiser JM, McGovern C, Matters GL, Smith JP, Kester M, Adair JH (2010) Bioconjugation of calcium phosphosilicate composite nanoparticles for selective targeting of human breast and pancreatic cancers in vivo. ACS Nano 4:1279–1287

    Article  Google Scholar 

  25. Barth BM, I Altinoğlu E, Shanmugavelandy SS, Kaiser JM, Crespo-Gonzalez D, DiVittore NA, McGovern C, Goff TM, Keasey NR, Adair JH, Loughran TP Jr, Claxton DF, Kester M (2011) Targeted indocyanine-green-loaded calcium phosphosilicate nanoparticles for in vivo photodynamic therapy of leukemia. ACS Nano 5:5325–5337

    Article  Google Scholar 

  26. Yu J, Yaseen MA, Anvari B, Wong MS (2007) Synthesis of near-infrared-absorbing nanoparticle-assembled capsules. Chem Mater 19:1277–1284

    Article  Google Scholar 

  27. Yu J, Javier D, Yaseen MA, Nitin N, Richards-Kortum R, Anvari B, Wong MS (2010) Self-assembly synthesis, tumor cell targeting, and photothermal capabilities of antibody-coated indocyanine green nanocapsules. J Am Chem Soc 132:1929–1938

    Article  Google Scholar 

  28. Yaseen MA, Yu J, Jung B, Wong MS, Anvari B (2009) Biodistribution of encapsulated indocyanine green in healthy mice. Mol Pharm 6(5):1321–1332

    Article  Google Scholar 

  29. Yaseen MA, Yu J, Wong MS, Anvari B (2008) In-vivo fluorescence imaging of mammalian organs using charge-assembled mesocapsule constructs containing indocyanine green. Opt Express 16:20577–20587

    Article  Google Scholar 

  30. Quan B, Choi K, Kim YH, Kang KW, Chung DS (2012) Near infrared dye indocyanine green doped silica nanoparticles for biological imaging. Talanta 99:387–393

    Article  Google Scholar 

  31. Sharma P, Bengtsson NE, Walter GA, Sohn HB, Zhou G, Iwakuma N, Zeng H, Grobmyer SR, Scott EW, Moudgil BM (2012) Gadolinium-doped silica nanoparticles encapsulating indocyanine green for near infrared and magnetic resonance imaging. Small 8:2856–2868

    Article  Google Scholar 

  32. Lee CH, Cheng SH, Wang YJ, Chen YC, Chen NT, Souris J, Chen CT, Mou CY, Yang CS, Lo LW (2009) Near-infrared mesoporous silica nanoparticles for optical imaging: characterization and in vivo biodistribution. Adv Funct Mater 19:215–222

    Article  Google Scholar 

  33. Cabral H, Matsumoto Y, Mizuno K, Chen Q, Murakami M, Kimura M, Terada Y, Kano MR, Miyazono K, Uesaka M, Nishiyama N, Kataoka K (2011) Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size. Nat Nanotechnol 6:815–823

    Article  Google Scholar 

  34. Murakami M, Cabral H, Matsumoto Y, Wu S, Kano MR, Yamori T, Nishiyama N, Kataoka K (2011) Improving drug potency and efficacy by nanocarrier-mediated subcellular targeting. Sci Transl Med 3:64ra2

    Article  Google Scholar 

  35. Matsumura Y (2011) Preclinical and clinical studies of NK012, an SN-38-incorporating polymeric micelles, which is designed based on EPR effect. Adv Drug Deliv Rev 63:184–192

    Article  Google Scholar 

  36. Matsumura Y (2008) Poly (amino acid) micelle nanocarriers in preclinical and clinical studies. Adv Drug Deliv Rev 60:899–914

    Article  Google Scholar 

  37. Nishiyama N, Kataoka K (2006) Current state, achievements, and future prospects of polymeric micelles as nanocarriers for drug and gene delivery. Pharmacol Ther 112:630–648

    Article  Google Scholar 

  38. Torchilin VP (2007) Micellar nanocarriers: pharmaceutical perspectives. Pharm Res 24:1–16

    Article  Google Scholar 

  39. Kedar U, Phutane P, Shidhaye S, Kadam V (2010) Advances in polymeric micelles for drug delivery and tumor targeting. Nanomedicine 6:714–729

    Google Scholar 

  40. Wang R, Xiao R, Zeng Z, Xu L, Wang J (2012) Application of poly(ethylene glycol)-distearoylphosphatidylethanolamine (PEG-DSPE) block copolymers and their derivatives as nanomaterials in drug delivery. Int J Nanomedicine 7:4185–4198

    Google Scholar 

  41. Chiu SJ, Marcucci G, Lee RJ (2006) Efficient delivery of an antisense oligodeoxyribonucleotide formulated in folate receptor-targeted liposomes. Anticancer Res 26:1049–1056

    Google Scholar 

  42. Yang X, Koh CG, Liu S, Pan X, Santhanam R, Yu B, Peng Y, Pang J, Golan S, Talmon Y, Jin Y, Muthusamy N, Byrd JC, Chan KK, Lee LJ, Marcucci G, Lee RJ (2009) Transferrin receptor-targeted lipid nanoparticles for delivery of an antisense oligodeoxyribonucleotide against Bcl-2. Mol Pharm 6:221–230

    Article  Google Scholar 

  43. Xiong XB, Huang Y, Lu WL, Zhang X, Zhang H, Nagai T, Zhang Q (2005) Intracellular delivery of doxorubicin with RGD-modified sterically stabilized liposomes for an improved antitumor efficacy: in vitro and in vivo. J Pharm Sci 94:1782–1793

    Article  Google Scholar 

  44. Allen TM (2002) Ligand-targeted therapeutics in anticancer therapy. Nat Rev Cancer 2:750–763

    Article  Google Scholar 

  45. Zheng C, Zheng M, Gong P, Jia D, Zhang P, Shi B, Sheng Z, Ma Y, Cai L (2012) Indocyanine green-loaded biodegradable tumor targeting nanoprobes for in vitro and in vivo imaging. Biomaterials 33:5603–5609

    Article  Google Scholar 

  46. Zheng M, Yue C, Ma Y, Gong P, Zhao P, Zheng C, Sheng Z, Zhang P, Wang Z, Cai L (2013) Single-step assembly of DOX/ICG loaded lipid – polymer nanoparticles for highly effective chemo-photothermal combination therapy. ACS Nano 7:2056–2067

    Article  Google Scholar 

  47. Zhao P, Zheng M, Yue C, Luo Z, Gong P, Gao G, Sheng Z, Zheng C, Cai L (2014) Improving drug accumulation and photothermal efficacy in tumor depending on size of ICG loaded lipid-polymer nanoparticles. Biomaterials 35:6037–6046

    Article  Google Scholar 

  48. Zheng X, Zhou F, Wu B, Chen WR, Xing D (2012) Enhanced tumor treatment using biofunctional indocyanine green-containing nanostructure by intratumoral or intravenous injection. Mol Pharm 9:514–522

    Article  Google Scholar 

  49. Zheng X, Xing D, Zhou F, Wu B, Chen WR (2011) Indocyanine green-containing nanostructure as near infrared dual-functional targeting probes for optical imaging and photothermal therapy. Mol Pharm 8:447–456

    Article  Google Scholar 

  50. Yokoyama M, Miyauchi M, Yamada N, Okano T, Sakurai Y, Kataoka K, Inoue S (1990) Characterization and anticancer activity of the micelle-forming polymeric anticancer drug adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer. Cancer Res 50:1693–1700

    Google Scholar 

  51. Chen H, Xiao L, Anraku Y, Mi P, Liu X, Cabral H, Inoue A, Nomoto T, Kishimura A, Nishiyama N, Kataoka K (2014) Polyion complex vesicles for photoinduced intracellular delivery of amphiphilic photosensitizer. J Am Chem Soc 136:157–163

    Article  Google Scholar 

  52. Osada K, Christie RJ, Kataoka K (2009) Polymeric micelles from poly(ethylene glycol)-poly(amino acid) block copolymer for drug and gene delivery. J R Soc Interface 3:S325–S339

    Article  Google Scholar 

  53. Yang H, Mao H, Wan Z, Zhu A, Guo M, Li Y, Li X, Wan J, Yang X, Shuai X, Chen H (2013) Micelles assembled with carbocyanine dyes for theranostic near-infrared fluorescent cancer imaging and photothermal therapy. Biomaterials 34:9124–9133

    Article  Google Scholar 

  54. Guo M, Mao H, Li Y, Zhu A, He H, Yang H, Wang Y, Tian X, Ge C, Peng Q, Wang X, Yang X, Chen X, Liu G, Chen H (2014) Dual imaging-guided photothermal/photodynamic therapy using micelles. Biomaterials 35:4656–4666

    Article  Google Scholar 

  55. Wan Z, Mao H, Guo M, Li Y, Zhu A, Yang H, He H, Shen J, Zhou L, Jiang Z, Ge C, Chen X, Yang X, Liu G, Chen H (2014) Highly efficient hierarchical micelles integrating photothermal therapy and singlet oxygen-synergized chemotherapy for cancer eradication. Theranostics 4:399–411

    Article  Google Scholar 

  56. Zhang L, Zhang R, Somasundaran P (2006) Adsorption of mixtures of nonionic sugar-based surfactants with other surfactants at solid/liquid interfaces II. Adsorption of n-dodecyl-beta-D-maltoside with a cationic surfactant and a nonionic ethoxylated surfactant on solids. J Colloid Interface Sci 302:25–31

    Article  Google Scholar 

  57. Kirchherr AK, Briel A, Mäder K (2009) Stabilization of indocyanine green by encapsulation within micellar systems. Mol Pharm 6:480–491

    Article  Google Scholar 

  58. Musacchio T, Laquintana V, Latrofa A, Trapani G, Torchilin VP (2009) PEG-PE micelles loaded with paclitaxel and surface-modified by a PBR-ligand: synergistic anticancer effect. Mol Pharm 6:468–479

    Article  Google Scholar 

  59. Deng J, Gao N, Wang Y, Yi H, Fang S, Ma Y, Cai L (2012) Self-assembled cationic micelles based on PEG-PLL-PLLeu hybrid polypeptides as highly effective gene vectors. Biomacromolecules 13:3795–3804

    Article  Google Scholar 

  60. Wu L, Fang S, Shi S, Deng J, Liu B, Cai L (2013) Hybrid polypeptide micelles loading indocyanine green for tumor imaging and photothermal effect study. Biomacromolecules 14:3027–3033

    Article  Google Scholar 

  61. Pitto-Barry A, Barry NPE (2014) Pluronic® block-copolymers in medicine: from chemical and biological versatility to rationalization and clinical advances. Polym Chem 5:3291–3297

    Article  Google Scholar 

  62. Kim TH, Chen Y, Mount CW, Gombotz WR, Li X, Pun SH (2010) Evaluation of temperature-sensitive, indocyanine green-encapsulating micelles for noninvasive near-infrared tumor imaging. Pharm Res 27:1900–1913

    Article  Google Scholar 

  63. Xu RX, Huang J, Xu JS, Sun D, Hinkle GH, Martin EW, Povoski SP (2009) Fabrication of indocyanine green encapsulated biodegradable microbubbles for structural and functional imaging of cancer. J Biomed Opt 14:034020

    Article  Google Scholar 

  64. Patel RH, Wadajkar AS, Patel NL, Kavuri VC, Nguyen KT, Liu H (2012) Multifunctionality of indocyanine green-loaded biodegradable nanoparticles for enhanced optical imaging and hyperthermia intervention of cancer. J Biomed Opt 17:046003

    Article  Google Scholar 

  65. Zhen Z, Tang W, Chen H, Lin X, Todd T, Wang G, Cowger T, Chen X, Xie J (2013) RGD-modified apoferritin nanoparticles for efficient drug delivery to tumors. ACS Nano 7:4830–4837

    Article  Google Scholar 

  66. Theil EC (1987) Ferritin: structure, gene regulation, and cellular function in animals, plants, and microorganisms. Annu Rev Biochem 56:289–315

    Article  Google Scholar 

  67. Lin X, Xie J, Niu G, Zhang F, Gao H, Yang M, Quan Q, Aronova MA, Zhang G, Lee S, Leapman R, Chen X (2011) Chimeric ferritin nanocages for multiple function loading and multimodal imaging. Nano Lett 11:814–819

    Article  Google Scholar 

  68. Liang M, Fan K, Zhou M, Duan D, Zheng J, Yang D, Feng J, Yan X (2014) H-ferritin-nanocaged doxorubicin nanoparticles specifically target and kill tumors with a single-dose injection. Proc Natl Acad Sci U S A 111:14900–14905

    Article  Google Scholar 

  69. Zhen Z, Tang W, Guo C, Chen H, Lin X, Liu G, Fei B, Chen X, Xu B, Xie J (2013) Ferritin nanocages to encapsulate and deliver photosensitizers for efficient photodynamic therapy against cancer. ACS Nano 7:6988–6996

    Article  Google Scholar 

  70. Garcia AM, Alarcon E, Muñoz M, Scaiano JC, Edwards AM, Lissi E (2011) Photophysical behaviour and photodynamic activity of zinc phthalocyanines associated to liposomes. Photochem Photobiol Sci 10:507–514

    Article  Google Scholar 

  71. Huang P, Rong P, Jin A, Yan X, Zhang MG, Lin J, Hu H, Wang Z, Yue X, Li W, Niu G, Zeng W, Wang W, Zhou K, Chen X (2014) Dye-loaded ferritin nanocages for multimodal imaging and photothermal therapy. Adv Mater 26:6401–6408

    Article  Google Scholar 

  72. Kratz F (2008) Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles. J Control Release 132:171–183

    Article  Google Scholar 

  73. Kratz F, Elsadek B (2012) Clinical impact of serum proteins on drug delivery. J Control Release 161:429–445

    Article  Google Scholar 

  74. Kratz F (2014) A clinical update of using albumin as a drug vehicle – a commentary. J Control Release 190:331–336

    Article  Google Scholar 

  75. Chen Q, Liang C, Wang X, He J, Li Y, Liu Z (2014) An albumin-based theranostic nano-agent for dual-modal imaging guided photothermal therapy to inhibit lymphatic metastasis of cancer post surgery. Biomaterials 35:9355–9362

    Article  Google Scholar 

  76. Chen Q, Wang C, Zhan Z, He W, Cheng Z, Li Y, Liu Z (2014) Near-infrared dye bound albumin with separated imaging and therapy wavelength channels for imaging-guided photothermal therapy. Biomaterials 35:8206–8214

    Article  Google Scholar 

  77. Sheng Z, Hu D, Zheng M, Zhao P, Liu H, Gao D, Gong P, Gao G, Zhang P, Ma Y, Cai L (2014) Smart human serum albumin-indocyanine green nanoparticles generated by programmed assembly for dual-modal imaging-guided cancer synergistic phototherapy. ACS Nano. doi:10.1021/nn5062386

    Google Scholar 

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Sheng, Z., Cai, L. (2016). Organic Dye-Loaded Nanoparticles for Imaging-Guided Cancer Therapy. In: Dai, Z. (eds) Advances in Nanotheranostics I. Springer Series in Biomaterials Science and Engineering, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-48544-6_7

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