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Multifunctional Liposomes for Imaging-Guided Therapy

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Advances in Nanotheranostics I

Part of the book series: Springer Series in Biomaterials Science and Engineering ((SSBSE,volume 6))

Abstract

Liposomes has enjoyed an explosive development in nanomedicine due to the exciting feature of easy combinations of diagnostic and/or therapeutic agents into a single agent. A variety of multifunctional liposomes have been developed by loading various therapeutic agents (e.g., radionuclides, doxorubicin, paclitaxel, siRNA, DNA) and imaging contrast agents (e.g., radionuclides, quantum dots, Gd complex, and Fe3O4). Each component would operate a different function, such as molecular targeting, contrast-enhanced imaging (e.g., nuclear, fluorescence, magnetic resonance, CT, photoacoustic, and ultrasound), and therapy (e.g., chemotherapy, photothermal therapy, photodynamic therapy, gene therapy, or combined therapy). Moreover, the surface of liposomes can be easily modified with ligands for targeting delivery to the diseased sites. In addition, the multimodality imaging functionalization of therapeutic drug carrying liposomes is of particular interest for personalized monitoring of the in vivo tumor targeting and pharmacokinetics of liposomal therapeutic agents, predicting therapy outcome, and gaining a better understanding of the prognosis-associated disease status by combining the advantageous information from each imaging modality. Therefore, multifunctional liposomes can serve as a theranostic nanomedicine for noninvasive imaging diagnosis, real-time imaging guidance, and remote-controlled therapeutics, especially imaging-guided therapeutics, enabling personalized detection and treatment of diseases with high efficacy. However, liposomes still have not attained their full potential because of insufficient stability. Recently, a hybrid liposomal cerasome with high stability has been developed to overcome general problems associated with current liposome technology. The present chapter first highlights some of the key advances of theranostic liposomes for imaging-guided therapy as a tool in personalized medicine.

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Acknowledgments

This research was financially supported by State Key Program of National Natural Science of China (No. 81230036), National Natural Science Foundation of China (No. 21273014), and National Natural Science Foundation for Distinguished Young Scholars (No. 81225011).

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  1. School of Municipal and Environmental Engineering, Harbin Institute of Technology, Harbin, 150001, China

    Xiuli Yue

  2. Department of Biomedical Engineering, College of Engineering, Peking University, Beijing, China

    Zhifei Dai

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    Zhifei Dai

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Yue, X., Dai, Z. (2016). Multifunctional Liposomes for Imaging-Guided Therapy. In: Dai, Z. (eds) Advances in Nanotheranostics I. Springer Series in Biomaterials Science and Engineering, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-48544-6_10

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