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ART for Antibacterial Infection

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Artemisinin and Nitric Oxide

Part of the book series: SpringerBriefs in Molecular Science ((BRIEFSMOLECULAR))

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Abstract

In Gram positive bacteria, bNOS-derived NO confers the protection of bacteria from environmental stress such as antibiotic challenges. ART can exert an antibiotic sensitizing role through inhibiting bNOS and CAT. Either in vivo or in vitro, ART can increase the bacteriocidal activity of antibiotics by abrogating the beneficial NO and enhancing the harmful H2O2, demonstrating a potential role in combating multidrug resistant bacteria.

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Authors and Affiliations

  1. Tropical Medicine Institute, Guangzhou University of Chinese Medicine, Guangzhou, China

    Qing-Ping Zeng

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  1. Qing-Ping Zeng
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Correspondence to Qing-Ping Zeng .

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Zeng, QP. (2015). ART for Antibacterial Infection. In: Artemisinin and Nitric Oxide. SpringerBriefs in Molecular Science. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-47688-8_4

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