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Transcutol® (Diethylene Glycol Monoethyl Ether): A Potential Penetration Enhancer

  • Chapter
Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement

Abstract

Transcutol® or diethylene glycol monoethyl ether is a liquid which has a long history of use in cosmetic and over-the-counter topically applied products. Transcutol® has been applied in several commercial preparations and is used in many studies as the main ingredient of formulations. It has been used in formulations as a co-surfactant and a penetration enhancer. It is frequently utilized in topical formulations (dermal drug delivery systems), transdermal delivery systems, and ocular and also intranasal delivery systems. It is also used as an ingredient in nanoemulsions, sunless tanning products, and in a wide range of hair-coloring products which are rinse-off products. This solvent will be a key component of many cosmetic products as well as dermatics in foreseeable future. In this chapter, some of the most important physicochemical properties of Transcutol® will be reviewed, as well as its application, pharmacology, and biomedical effects and toxicity.

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Authors and Affiliations

  1. Drug Applied Research Centre, Faculty of Pharmacy, Tabriz University of Medical Sciences, Daneshgah Street, Tabriz, 51664, Iran

    Yousef Javadzadeh & Hamed Hamishekar

  2. Biotechnology Research Center, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, 51664, Iran

    Khosro Adibkia

Authors
  1. Yousef Javadzadeh
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  2. Khosro Adibkia
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  3. Hamed Hamishekar
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Corresponding author

Correspondence to Yousef Javadzadeh .

Editor information

Editors and Affiliations

  1. Department of Manufacturing, Apoteka "Beograd", Belgrade, Serbia

    Nina Dragicevic

  2. Dermatology Clinic, University of California San Francisco Dermatology Clinic, San Francisco, USA

    Howard I. Maibach

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Javadzadeh, Y., Adibkia, K., Hamishekar, H. (2015). Transcutol® (Diethylene Glycol Monoethyl Ether): A Potential Penetration Enhancer. In: Dragicevic, N., Maibach, H. (eds) Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-47039-8_12

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  • DOI: https://doi.org/10.1007/978-3-662-47039-8_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-47038-1

  • Online ISBN: 978-3-662-47039-8

  • eBook Packages: MedicineMedicine (R0)

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