Abstract
Cheilitis is a generic term that denotes inflammation of the lips. However, specific types of cheilitis have been described that may represent a variety of systemic and local disorders. Accurate diagnosis is key in identifying the pathology and administering of the proper treatment. Types of cheilitis described include angular cheilitis, exfoliative cheilitis, allergic contact cheilitis, actinic cheilitis, cheilitis glandularis, and cheilitis granulomatosa. Diagnosis is most often clinical, with biopsy needed in actinic cheilitis, cheilitis, glandularis, and cheilitis granulomatosa. Topical or systemic treatment may be indicated according to diagnosis. Moisturizing agents are frequently needed to enable better treatment.
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Alajbeg I, Rogulj AA, Hutinec Z. Orofacial granulomatosis treated with intralesional triamcinolone. Acta Dermatovenerol Croat. 2011;19(3):165–9.
Almazrooa SA, Woo SB, Mawardi H, Treister N. Characterization and management of exfoliative cheilitis: a single-center experience. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;116(6):e485–9.
Andrade ES, Sobral AP, Laureano Filho JR, Santos ME, Camargo IB. Cheilitis glandularis and actinic cheilitis: differential diagnoses – report of three unusual cases. Dermatol Online J. 2009;15(1):5.
Arias-Santiago S, Orgaz-Molina J, Naranjo-Sintes R. Persistent swollen lip: cheilitis granulomatosa. Lancet. 2013;381(9885):2280.
Bangsgaard N, Weile B, Skov L. Organised angular cheilitis as the initial sign of Crohn’s disease in two children. Acta Derm Venereol. 2011;91(2):207–8.
Banks T, Gada S. A comprehensive review of current treatments for granulomatous cheilitis. Br J Dermatol. 2012;166(5):934–7.
Bovenschen HJ. Novel treatment for cheilitis glandularis. Acta Derm Venereol. 2009;89(1):99–100.
Budimir V, Brailo V, Alajbeg I, Vucicevic Boras V, Budimir J. Allergic contact cheilitis and perioral dermatitis caused by propolis: case report. Acta Dermatovenerol Croat. 2012;20(3):187–90.
Buyuktiryaki AB, Bezirganoglu H, Sahiner UM, Yavuz ST, Tuncer A, Kara A, et al. Patch testing is an effective method for the diagnosis of carbamazepine-induced drug reaction, eosinophilia and systemic symptoms (DRESS) syndrome in an 8-year-old girl. Australas J Dermatol. 2012;53(4):274–7.
Campbell C, Parish LC. Angular cheilitis: a maligned condition. Skinmed. 2013;11(4):198–200.
Chi AC, Neville BW, Krayer JW, Gonsalves WC. Oral manifestations of systemic disease. Am Fam Physician. 2010;82(11):1381–8.
Collet E, Jeudy G, Dalac S. Cheilitis, perioral dermatitis and contact allergy. Eur J Dermatol. 2013;23:303–7.
Critchlow WA, Chang D. Cheilitis granulomatosa: a review. Head Neck Pathol. 2014;8:209–13.
Discacciati JA, Lemos de Souza E, Vasconcellos WA, Costa SC, Barros Vde M. Increased vertical dimension of occlusion: signs, symptoms, diagnosis, treatment and options. J Contemp Dent Pract. 2013;14(1):123–8.
Elias MK, Mateen FJ, Weiler CR. The Melkersson-Rosenthal syndrome: a retrospective study of biopsied cases. J Neurol. 2013;260(1):138–43.
Gamboni SE, Palmer AM, Nixon RL. Allergic contact stomatitis to dodecyl gallate? A review of the relevance of positive patch test results to gallates. Australas J Dermatol. 2013;54(3):213–7.
Hanami Y, Motoki Y, Yamamoto T. Successful treatment of plasma cell cheilitis with topical tacrolimus: report of two cases. Dermatol Online J. 2011;17(2):6.
Harikishan G, Reddy NR, Prasad H, Anitha S. Oral Crohn’s disease without intestinal manifestations. J Pharm Bioallied Sci. 2012;4 Suppl 2:S431–4.
Jadotte YT, Schwartz RA. Solar cheilosis: an ominous precursor: part I. Diagnostic insights. J Am Acad Dermatol. 2012a;66(2):173–84; quiz 85–6.
Jadotte YT, Schwartz RA. Solar cheilosis: an ominous precursor part II. Therapeutic perspectives. J Am Acad Dermatol. 2012b;66(2):187–98; quiz 99–200.
Lynde CB, Bruce AJ, Orvidas LJ, Rogers 3rd RS, Depry JL. Cheilitis granulomatosa treated with intralesional corticosteroids and anti-inflammatory agents. J Am Acad Dermatol. 2011;65(3):e101–2.
Mariano M, Patruno C, Lembo S, Balato N. Contact cheilitis in a saxophonist. Dermatitis. 2010;21(2):119–20.
McDonald C, Laverick S, Fleming CJ, White SJ. Treatment of actinic cheilitis with imiquimod 5% and a retractor on the lower lip: clinical and histological outcomes in 5 patients. Br J Oral Maxillofac Surg. 2010;48(6):473–6.
Nico MM, Nakano de Melo J, Lourenco SV. Cheilitis glandularis: a clinicopathological study in 22 patients. J Am Acad Dermatol. 2010;62(2):233–8.
Nico MM, Melo JN, Lourenco SV. Cheilitis glandularis: immunohistochemical expression of protein water channels (aquaporins) in minor labial salivary glands. J Eur Acad Dermatol Venereol. 2014;28:382–7.
Pugliarello S, Cozzi A, Gisondi P, Girolomoni G. Phenotypes of atopic dermatitis. J Dtsch Dermatol Ges. 2011;9(1):12–20.
Rana AP. Orofacial granulomatosis: a case report with review of literature. J Indian Soc Periodontol. 2012;16(3):469–74.
Rao R, Kaur GJ, Rao AC, Chandrashekar B, Rao L, Handattu S. Borderline leprosy masquerading as cheilitis granulomatosa: a case report. Lepr Rev. 2013;84(1):95–9.
Reiter S, Vered M, Yarom N, Goldsmith C, Gorsky M. Cheilitis glandularis: clinico-histopathological diagnostic criteria. Oral Dis. 2011;17(3):335–9.
Rose AE, Leger M, Chu J, Meehan S. Cheilitis granulomatosa. Dermatol Online J. 2011;17(10):15.
Ruiz Villaverde R, Sanchez Cano D. Successful treatment of granulomatous cheilitis with adalimumab. Int J Dermatol. 2012;51(1):118–20.
Shah AY, Doherty SD, Rosen T. Actinic cheilitis: a treatment review. Int J Dermatol. 2010;49(11):1225–34.
Sharon V, Fazel N. Oral candidiasis and angular cheilitis. Dermatol Ther. 2010;23(3):230–42.
Sobjanek M, Michajlowski I, Zelazny I, Medrzycka-Dabrowska W, Wlodarkiewicz A. What is the most effective treatment of cheilitis granulomatosa in Melkersson-Rosenthal syndrome? J Eur Acad Dermatol Venereol. 2010;24(3):364–5.
Stoopler ET, Nadeau C, Sollecito TP. How do I manage a patient with angular cheilitis? J Can Dent Assoc. 2013;79:d68.
Wiesenfeld D, Ferguson MM, Mitchell DN, MacDonald DG, Scully C, Cochran K, et al. Oro-facial granulomatosis–a clinical and pathological analysis. Q J Med. 1985;54(213):101–13.
Yanagawa T, Yamaguchi A, Harada H, Yamagata K, Ishibashi N, Noguchi M, et al. Cheilitis glandularis: two case reports of asian-Japanese men and literature review of Japanese cases. ISRN Dent. 2011;2011:457567.
Zug KA, Kornik R, Belsito DV, DeLeo VA, Fowler Jr JF, Maibach HI, et al. Patch-testing North American lip dermatitis patients: data from the North American Contact Dermatitis Group, 2001 to 2004. Dermatitis. 2008;19(4):202–8.
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Gagari, E. (2015). Cheilitis and Oral Disease. In: Katsambas, A.D., Lotti, T.M., Dessinioti, C., D’Erme, A.M. (eds) European Handbook of Dermatological Treatments. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-45139-7_13
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DOI: https://doi.org/10.1007/978-3-662-45139-7_13
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