Skip to main content
SpringerLink
Log in

Nausea and Vomiting

  • Chapter
  • First Online:
Supportive Care in Pediatric Oncology

Part of the book series: Pediatric Oncology ((PEDIATRICO))

  • 1453 Accesses

Abstract

Nausea and vomiting induced by antineoplastic therapy can significantly affect quality of life and continues to be a prevalent and distressing treatment-related issue faced by children with cancer and their families. Chemotherapy-induced nausea and vomiting (CINV) can result in metabolic derangements, nutritional depletion and anorexia, esophageal tears, deterioration of mental and performance status, prolonged hospitalizations, and potential poor compliance or withdrawal from anticancer treatment. Despite advances in pharmacologic and nonpharmacologic management of nausea and vomiting, prevention of CINV remains a particular issue in the pediatric population where existing guidelines are constrained by lack of robust evidence. Few studies have been carried out in children, and results obtained in adults cannot be directly applied to young children since metabolism and side effects of drugs differ. The pathophysiology of CINV, principles of antiemetic prophylaxis, emetogenicity of chemotherapy, classes of antiemetic agents, and current guidelines for prevention and treatment of CINV in children are addressed in this chapter. Specific attention is also given to nonpharmacologic strategies and approaches to anticipatory, breakthrough, and radiation-induced nausea and vomiting. This chapter provides health care providers with a summary of evidence-based information with the goal of guiding optimal emetic control in pediatric cancer patients.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 159.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Abrahamov A, Abrahamov A, Mechoulam R (1995) An efficient new cannabinoid antiemetic in pediatric oncology. Life Sci 56:2097–2102

    Article  CAS  PubMed  Google Scholar 

  • Allen JC, Gralla R, Reilly L et al (1985) Metoclopramide: dose-related toxicity and preliminary antiemetic studies in children receiving cancer chemotherapy. J Clin Oncol 3:1136–1141

    CAS  PubMed  Google Scholar 

  • Alvarez O, Freeman A, Bedros A (1995) Randomized double-blind crossover ondansetron-dexamethasone versus ondansetron-placebo study for the treatment of chemotherapy-induced nausea and vomiting in pediatric patients with malignancies. J Pediatr Hematol Oncol 17:145–150

    Article  CAS  PubMed  Google Scholar 

  • American Society of Health-System Pharmacists (1999) ASHP therapeutic guidelines on the pharmacologic management of nausea and vomiting in adult and pediatric patients receiving chemotherapy or radiation therapy or undergoing surgery. Am J Health Syst Pharm 56:729–764

    Google Scholar 

  • Basch E, Prestrud A, Hesketh P et al (2011) Antiemetics: American Society of Clinical Oncology clinical practice guideline update. J Clin Oncol 29:4189–4198

    Article  PubMed  Google Scholar 

  • Bauters TG, Verlooy J, Robays H et al (2013) Emesis control by aprepitant in children and adolescents with chemotherapy. Int J Clin Pharm 35:1021–1024

    Article  CAS  PubMed  Google Scholar 

  • Bodge M, Shillingburg A, Paul S, Biondo L (2014) Safety and efficacy of aprepitant for chemotherapy-induced nausea and vomiting in pediatric patients: a prospective, observational study. Pediatr Blood Cancer 61:1111–1113

    Article  CAS  PubMed  Google Scholar 

  • Buyukavci M, Olgun H, Ceviz N (2005) The effects of ondansetron and granisetron on electrocardiography in children receiving chemotherapy for acute leukemia. Am J Clin Oncol 28:201–204

    Article  CAS  PubMed  Google Scholar 

  • Carden PA, Mitchell SL, Waters SK et al (1990) Prevention of cyclophosphamide/cytarabine-induced emesis with ondansetron in children with leukemia. J Clin Oncol 8:1531–1535

    CAS  PubMed  Google Scholar 

  • Carpenter DO (1990) Neural mechanisms of emesis. Can J Physiol Pharmacol 68:230–236

    Article  CAS  PubMed  Google Scholar 

  • Chan H, Correia J, MacLeod S (1987) Nabilone versus prochlorperazine for control of cancer chemotherapy-induced emesis in children: a double-blind, crossover trial. Pediatrics 79:946–952

    CAS  PubMed  Google Scholar 

  • Choi MR, Jiles C, Seibel NL (2010) Aprepitant use in children, adolescents, and young adults for the control of chemotherapy induced nausea and vomiting (CINV). J Pediatr Hematol Oncol 32:e268–e271

    Article  PubMed  Google Scholar 

  • Corapcioglu F, Sarper N (2005) A prospective randomized trial of the antiemetic efficacy and cost-effectiveness of intravenous and orally disintegrating tablet of ondansetron in children with cancer. Pediatr Hematol Oncol 22:103–114

    Article  CAS  PubMed  Google Scholar 

  • Croom KF, Keating GM (2006) Metopimazine. Am J Cancer 5:123–136

    Article  CAS  Google Scholar 

  • Culy CR, Bhana N, Plosker GL (2001) Ondansetron: a review of its use as an antiemetic in children. Paediatr Drugs 3:441–479

    Article  CAS  PubMed  Google Scholar 

  • De Leon A (2006) Palonosetron (Aloxi): a second-generation 5-HT3 receptor antagonist for chemotherapy-induced nausea and vomiting. Proc (Bayl Univ Med Cent) 19:413–416

    Google Scholar 

  • Dick GS, Meller ST, Pinkerton CR (1995) Randomised comparison of ondansetron and metoclopramide plus dexamethasone for chemotherapy induced emesis. Arch Dis Child 73:243–245

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Dodds LJ (1985) The control of cancer chemotherapy-induced nausea and vomiting. J Clin Hosp Pharm 10:143–166

    CAS  PubMed  Google Scholar 

  • Dupuis LL, Taddio A, Kerr EN et al (2006) Development and validation of a pediatric nausea assessment tool (PeNAT) for use by children receiving antineoplastic agents. Pharmacotherapy 26:1221–1231

    Article  PubMed  Google Scholar 

  • Dupuis LL, Milne-Wren C, Cassidy M et al (2010) Symptom assessment in children receiving cancer therapy: the parents’ perspective. Support Care Cancer 18:281–299

    Article  PubMed  Google Scholar 

  • Dupuis LL, Boodhan S, Sung L et al (2011) Guideline for the classification of the acute emetogenic potential of antineoplastic medication in pediatric cancer patients. Pediatr Blood Cancer 57:191–198

    Article  PubMed  Google Scholar 

  • Dupuis LL, Boodhan S, Holdsworth M et al (2013) Guideline for the prevention of acute nausea and vomiting due to antineoplastic medication in pediatric cancer patients. Pediatr Blood Cancer 60:1073–1082

    Article  PubMed  Google Scholar 

  • Eisenberg P, Figueroa-Vadillo J, Zamora R et al (2003) Improved prevention of moderately emetogenic chemotherapy induced nausea and vomiting with palonosetron, a pharmacologically novel 5-HT3 receptor antagonist: results of a Phase III, single-dose trial versus dolasetron. Cancer 98:2473–2482

    Article  CAS  PubMed  Google Scholar 

  • Ettinger D, Akerley W, Benson A et al (2012) National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology: Antiemesis, V.1.2012 http://www.nccn.org/professionals/physician_gls/PDF/antiemesis.pdf

  • Ezzo J, Streitberger K, Schneider A (2006) Cochrane systematic reviews examine P6 acupuncture-point stimulation for nausea and vomiting. J Altern Complement Med 12:489–495

    Article  PubMed  Google Scholar 

  • Feyer PC, Maranzano E, Molassiotis A (2005) Radiotherapy-induced nausea and vomiting (RINV): antiemetic guidelines. Support Care Cancer 13:122–128

    Article  PubMed  Google Scholar 

  • Figueroa-Moseley C, Jean-Pierre P, Roscoe JA et al (2007) Behavioral interventions in treating anticipatory nausea and vomiting. J Natl Compr Canc Netw 5:44–50

    PubMed  Google Scholar 

  • Gebbia V, Cannata G, Testa A et al (1994) Ondansetron versus granisetron in the prevention of chemotherapy-induced nausea and vomiting. Results of a prospective randomized trial. Cancer 74:1945–1952

    Article  CAS  PubMed  Google Scholar 

  • Geling O, Eichler HG (2005) Should 5-hydroxytryptamine-3 receptor antagonists be administered beyond 24 hours after chemotherapy to prevent delayed emesis? Systematic re-evaluation of clinical evidence and drug cost implications. J Clin Oncol 23:1289–1294

    Article  CAS  PubMed  Google Scholar 

  • Gore L, Chawla SP, Petrilli AS et al (2009) Aprepitant in adolescent patients for prevention of chemotherapy-induced nausea and vomiting: a randomized, double-blind, placebo-controlled study of efficacy and tolerability. Pediatr Blood Cancer 52:242–247

    Article  PubMed  Google Scholar 

  • Gralla R, Lichinitser M, Van Der Vegt S et al (2003) Palonosetron improves prevention of chemotherapy-induced nausea and vomiting following moderately emetogenic chemotherapy: results of a double-blind randomized phase III trial comparing single doses of palonosetron with ondansetron. Ann Oncol 14:1570–1577

    Article  CAS  PubMed  Google Scholar 

  • Grunberg SM, Deuson RR, Mavros P et al (2004) Incidence of chemotherapy-induced nausea and emesis after modern antiemetics. Cancer 100:2261–2268

    Article  PubMed  Google Scholar 

  • Grunberg SM, Warr D, Gralla RJ et al (2010) Evaluation of new antiemetic agents and definition of antineoplastic agent emetogenicity-state of the art. Support Care Cancer 19:S43–S47

    Article  PubMed  Google Scholar 

  • Guyatt G, Gutterman D, Baumann MH et al (2006) Grading strength of recommendations and quality of evidence in clinical guidelines: report from an American College of Chest Physicians Task Force. Chest 129:174–181

    Article  PubMed  Google Scholar 

  • Hählen K, Quintana E, Pinkerton CR, Cedar E (1995) A randomized comparison of intravenously administered granisetron versus chlorpromazine plus dexamethasone in the prevention of ifosfamide-induced emesis in children. J Pediatr 126:309–313

    Article  PubMed  Google Scholar 

  • Hasler S, Hirt A, Ridolfi Luethy A et al (2008) Safety of ondansetron loading doses in children with cancer. Support Care Cancer 16:469–475

    Article  PubMed  Google Scholar 

  • Herrstedt J (2008) Antiemetics: an update and the MASCC guidelines applied in clinical practice. Nat Clin Pract Oncol 5:32–43

    Article  CAS  PubMed  Google Scholar 

  • Hesketh PJ (1994) Treatment of chemotherapy-induced emesis in the 1990s: impact of the 5-HT3 receptor antagonists. Support Care Cancer 2:286–292

    Article  CAS  PubMed  Google Scholar 

  • Hesketh PJ (2008) Chemotherapy-induced nausea and vomiting. N Engl J Med 358:2482–2494

    Article  CAS  PubMed  Google Scholar 

  • Hesketh PJ, Kris MG, Grunberg SM et al (1997) Proposal for classifying the acute emetogenicity of cancer chemotherapy. J Clin Oncol 15:103–109

    CAS  PubMed  Google Scholar 

  • Hesketh PJ, Grunberg SM, Gralla RJ et al (2003) The oral neurokinin-1 antagonist aprepitant for the prevention of chemotherapy-induced nausea and vomiting: a multi-national, randomized, double-blind, placebo-controlled trial in patients receiving high-dose cisplati-he Aprepitant Protocol 052 Study Group. J Clin Oncol 21:4112–4119

    Article  CAS  PubMed  Google Scholar 

  • Hewitt M, McQuade B, Stevens R (1993) The efficacy and safety of ondansetron in the prophylaxis of cancer-chemotherapy induced nausea and vomiting in children. Clin Oncol 5:11–14

    Article  CAS  Google Scholar 

  • Hickok JT, Roscoe JA, Morrow GR et al (2003) Nausea and emesis remain significant problems of chemotherapy despite prophylaxis with 5-hydroxytryptamine-3 antiemetics: a University of Rochester James P. Wilmot Cancer Center Community Clinical Oncology Program Study of 360 cancer patients treated in the community. Cancer 97:2880–2886

    Article  CAS  PubMed  Google Scholar 

  • Hirota T, Honjo T, Kuroda R et al (1993) Antiemetic efficacy of granisetron in pediatric cancer treatment—(2). Comparison of granisetron and granisetron plus methylprednisolone as antiemetic prophylaxis. Gan To Kagaku Ryoho 20:2369–2373

    CAS  PubMed  Google Scholar 

  • Holdsworth MT, Raisch DW, Frost J (2006) Acute and delayed nausea and emesis control in pediatric oncology patients. Cancer 106:931–940

    Article  PubMed  Google Scholar 

  • Jimenez M, Leon P, Gimeno J (1997) Comparison of chlorpromazine plus dexamethasone vs. ondansetron vs. tropisetron in the treatment of emesis induced by highly and moderately emetogenic chemotherapy in pediatric patients with malignancies. International Society of Pediatric Oncology XXIX meeting, Istanbul

    Google Scholar 

  • Jin Y, Wu X, Guan Y et al (2012) Efficacy and safety of aprepitant in the prevention of chemotherapy-induced nausea and vomiting: a pooled analysis. Support Care Cancer 20:1815–1822

    Article  PubMed  Google Scholar 

  • Jindal V, Ge A, Mansky P (2008) Safety and efficacy of acupuncture in children. J Pediatr Hematol Oncol 30:431–442

    Article  PubMed Central  PubMed  Google Scholar 

  • Jordan K, Hinke A, Grothey A et al (2007) A meta-analysis comparing the efficacy of four 5-HT3-receptor antagonists for acute chemotherapy- induced emesis. Support Care Cancer 15:1023–1033

    Article  CAS  PubMed  Google Scholar 

  • Jordan K, Roila F, Molassiotis A et al (2011) Antiemetics in children receiving chemotherapy. MASCC/ESMO guideline update 2009. Support Care Cancer 19:S37–S42

    Article  PubMed  Google Scholar 

  • Kadota R, Shen V, Messinger Y (2007) Safety, pharmacokinetics, and efficacy of palonosetron in pediatric patients: a multicenter, stratified, double-blind, phase 3, randomized study [abstract]. J Clin Oncol 25:9570

    Google Scholar 

  • Komada Y, Matsuyama T, Takao A et al (1999) A randomised dose-comparison trial of granisetron in preventing emesis in children with leukemia receiving emetogenic chemotherapy. Eur J Cancer 35:1095–1101

    Article  CAS  PubMed  Google Scholar 

  • Koseoglu V, Kurekci A, Atay A, Ozcan O (1998) Comparison of the efficacy and side-effects of ondansetron and metoclopramide-diphenhydramine administered to control nausea and vomiting in children treated with antineoplastic chemotherapy: a prospective randomized study. Eur J Pediatr 157:806–810

    Article  CAS  PubMed  Google Scholar 

  • Laszlo J (1983) Emesis as limiting toxicity in cancer chemotherapy. In: Laszlo J (ed) Antiemetics and cancer chemotherapy. Williams & Wilkins, Baltimore, pp 1–5

    Google Scholar 

  • Likun Z, Xiang J, Yi B et al (2011) A systematic review and meta-analysis of intravenous palonosetron in the prevention of chemotherapy-induced nausea and vomiting in adults. Oncologist 16:207–216

    Article  PubMed Central  PubMed  Google Scholar 

  • Marshall G, Kerr S, Vowels M et al (1989) Antiemetic therapy for chemotherapy-induced vomiting: metoclopramide, benztropine, dexamethasone, and lorazepam regimen compared with chlorpromazine. J Pediatr 115:156–160

    Article  CAS  PubMed  Google Scholar 

  • Matthews A, Haas DM, O’Mathúna DP et al (2014) Interventions for nausea and vomiting in early pregnancy. Cochrane Database Syst Rev (3):CD007575

    Google Scholar 

  • Mehta P, Gross S, Graham-Pole J et al (1986) Methylprednisolone for chemotherapy-induced emesis: a double-blind randomized trial in children. J Pediatr 108:774–776

    Article  CAS  PubMed  Google Scholar 

  • Miller AD, Leslie RA (1994) The area postrema and vomiting. Front Neuroendocrinol 15:301–320

    Article  CAS  PubMed  Google Scholar 

  • Mitchell EP (1992) Gastrointestinal toxicity of chemotherapeutic agents. Semin Oncol 19:566–579

    CAS  PubMed  Google Scholar 

  • Moertel CG, Reitemeier RJ, Gage RP (1963) A controlled clinical evaluation of antiemetic drugs. JAMA 186:116–118

    Article  CAS  PubMed  Google Scholar 

  • Molassiotis A, Stricker C, Eaby B et al (2008) Understanding the concept of chemotherapy-related nausea: the patient experience. Eur J Cancer Care 17:444–453

    Article  CAS  Google Scholar 

  • Morrow GR (1984) Clinical characteristics associated with the development of anticipatory nausea and vomiting in cancer patients undergoing chemotherapy treatment. J Clin Oncol 2:1170–1176

    CAS  PubMed  Google Scholar 

  • Navari RM, Einhorn LH, Passik SD et al (2005) A phase II trial of olanzapine for the prevention of chemotherapy-induced nausea and vomiting: a Hoosier Oncology Group study. Support Care Cancer 13:529–534

    Article  PubMed  Google Scholar 

  • Navari RM, Einhorn LH, Loehrer PJ Sr et al (2007) A phase II trial of olanzapine, dexamethasone, and palonosetron for the prevention of chemotherapy-induced nausea and vomiting: a Hoosier oncology group study. Support Care Cancer 15:1285–1291

    Article  PubMed  Google Scholar 

  • Phillips RS, Gopaul S, Gibson F et al (2010) Antiemetic medication for prevention and treatment of chemotherapy induced nausea and vomiting in childhood. Cochrane Database Syst Rev (9):CD007786

    Google Scholar 

  • Pillai AK, Sharma KK, Gupta YK, Bakhshi S (2011) Anti-emetic effect of ginger powder versus placebo as an add-on therapy in children and young adults receiving high emetogenic chemotherapy. Pediatr Blood Cancer 56:234–238

    Article  PubMed  Google Scholar 

  • Pinarli FG, Elii M, Dagdemir A et al (2006) Electrocardiographic findings after 5-HT3 receptor antagonists and chemotherapy in children with cancer. Pediatr Blood Cancer 47:567–571

    Article  CAS  PubMed  Google Scholar 

  • Reindl TK, Geilen W, Hartmann R et al (2006) Acupuncture against chemotherapy-induced nausea and vomiting in pediatric oncology: interim results of a multicenter crossover study. Support Care Cancer 14:172–176

    Article  PubMed  Google Scholar 

  • Richardson JL, Marks G, Levine A (1988) The influence of symptoms of disease and side effects of treatment on compliance with cancer therapy. J Clin Oncol 6:1746–1752

    CAS  PubMed  Google Scholar 

  • Richardson J, Smith JE, McCall G et al (2007) Hypnosis for nausea and vomiting in cancer chemotherapy: a systematic review of the research evidence. Eur J Cancer Care 16:402–412

    Article  CAS  Google Scholar 

  • Rodgers C, Kollar D, Taylor O et al (2012) Nausea and vomiting perspectives among children receiving moderate to highly emetogenic chemotherapy treatment. Cancer Nurs 35:203–210

    Article  PubMed  Google Scholar 

  • Roila F, Aapro M, Stewart A (1998) Optimal selection of antiemetics in children receiving cancer chemotherapy. Support Care Cancer 6:215–220

    Article  CAS  PubMed  Google Scholar 

  • Roila F, Hesketh PJ, Herrstedt J (2006) Prevention of chemotherapy- and radiotherapy-induced emesis: results of the 2004 Perugia International Antiemetic Consensus Conference. Ann Oncol 17:20–28

    Article  CAS  PubMed  Google Scholar 

  • Ryan JL, Heckler CE, Roscoe JA et al (2012) Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients. Support Care Cancer 20:1479–1489

    Article  PubMed Central  PubMed  Google Scholar 

  • Saito R, Takano Y, Kamiya HO (2003) Roles of substance P and NK(1) receptor in the brainstem in the development of emesis. J Pharmacol Sci 91:87–94

    Article  CAS  PubMed  Google Scholar 

  • Sandoval C, Corbi D, Strobino B, Ozkaynak M (1999) Randomized double-blind comparison of single high-dose ondansetron and multiple standard-dose ondansetron in chemotherapy-naive pediatric oncology patients. Cancer Invest 17:309–313

    Article  CAS  PubMed  Google Scholar 

  • Schwartzberg L (2006) Chemotherapy-induced nausea and vomiting: state of the art in 2006. J Support Oncol 4:3–8

    CAS  PubMed  Google Scholar 

  • Sepulveda-Vildosola A, Betanzos-Cabrera Y, Lastiri G et al (2008) Palonosetron hydrochloride is an effective and safe option to prevent chemotherapy-induced nausea and vomiting in children. Arch Med Res 39:601–606

    Article  CAS  PubMed  Google Scholar 

  • Shadle C, Lee Y, Majumdar A et al (2004) Evaluation of potential inductive effects of aprepitant on cytochrome P450 3A4 and 2C9 activity. J Clin Pharmacol 44:215–223

    Article  CAS  PubMed  Google Scholar 

  • Small BE, Holdsworth MT, Raisch DW, Winter SS (2000) Survey ranking of emetogenic control in children receiving chemotherapy. J Pediatr Hematol Oncol 22:125–132

    Article  CAS  PubMed  Google Scholar 

  • Straathof CS, Van Den Bent MJ, Ma J et al (1998) The effect of dexamethasone on the update of cisplatin in 9L glioma and the area of brain around tumor. J Neurooncol 37:1–8

    Article  CAS  PubMed  Google Scholar 

  • Terrin BN, McWilliams NB, Maurer HM (1984) Side effects of metoclopramide as an antiemetic in childhood cancer chemotherapy. J Pediatr 104:138–140

    Article  CAS  PubMed  Google Scholar 

  • Tramer M, Carrroll F, Campbell FA et al (2001) Cannabinoids for control of chemotherapy-induced nausea and vomiting: quantitative systematic review. BMJ 323:1–8

    Article  Google Scholar 

  • Triozzi PL, Goldstein D, Laszlo J (1988) Contributions of benzodiazepines to cancer therapy. Cancer Invest 6:103–111

    Article  CAS  PubMed  Google Scholar 

  • Tyc V, Mulhern R, Fairclough D et al (1993) Chemotherapy induced nausea and emesis in pediatric cancer patients: external validity of child and parent emesis ratings. J Dev Behav Pediatr 14:236–241

    Article  CAS  PubMed  Google Scholar 

  • Van Hoff J, Olszewski D (1988) Lorazepam for the control of chemotherapy-related nausea and vomiting in children. J Pediatr 113:146–149

    Article  PubMed  Google Scholar 

  • Weidenfeld J, Lysy J, Shohami E (1987) Effect of dexamethasone on prostaglandin synthesis in various areas of the rat brain. J Neurochem 48:1351–1354

    Google Scholar 

  • White L, Daly S, McKenna C et al (2000) A comparison of oral ondansetron syrup or intravenous ondansetron loading dose regimens given in combination with dexamethasone for the prevention of nausea and emesis in pediatric and adolescent patients receiving moderately/highly emetogenic chemotherapy. Pediatr Hematol Oncol 17:445–455

    Article  CAS  PubMed  Google Scholar 

  • Wickham R (1999) Nausea and vomiting. In: Yarbo CH, Frogge MH, Goodman M (eds) Cancer symptom management, 2nd edn. Jones and Bartlett Publishers, Sudbury, pp 228–263

    Google Scholar 

  • Zick SM, Ruffin MT, Lee J et al (2009) Phase II trial of encapsulated ginger as a treatment for chemotherapy-induced nausea and vomiting. Support Care Cancer 17:563–572

    Article  PubMed Central  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Hematology/Oncology, Department of Pediatrics, Benioff Children’s Hospital, University of California-San Francisco, 505 Parnassus Avenue, San Francisco, CA, 94143, USA

    Tiffany Chang MD

Authors
  1. Tiffany Chang MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Tiffany Chang MD .

Editor information

Editors and Affiliations

  1. Department of Hematology and Oncology, Childrens Hospital & Research Center Oak, Oakland, California, USA

    James H. Feusner

  2. Hematology/Oncology, Children's Hospital and Research Center, Oakland, California, USA

    Caroline A. Hastings

  3. Hematology/Oncology, Children's Hospital and Research Center, Oakland, California, USA

    Anurag K. Agrawal

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer Berlin Heidelberg

About this chapter

Cite this chapter

Chang, T. (2015). Nausea and Vomiting. In: Feusner, J., Hastings, C., Agrawal, A. (eds) Supportive Care in Pediatric Oncology. Pediatric Oncology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-44317-0_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-44317-0_10

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-44316-3

  • Online ISBN: 978-3-662-44317-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation