Summary
The secretory diencephalo-hypophyseal system is constituted by peptidergic and aminergic nerve cells of the hypothalamus. The terminals of their axons reach the walls of the capillaries in the median eminence and in the neurohypophysis. Part of the peptidergic and aminergic fibers end by means of synapses on the epithelial cells of the pars intermedia and on the pituicytes of the posterior hypophyseal lobe. Small aminergic nerve fibers of diencephalic origin penetrate into the interstitium of the pars tuberalis of the hypophysis but are not involved in the formation of synapses. Evidently, these are perivascular nerve fibers. In the remaining parts of the mammalian adenohypophysis we have not been able to demonstrate synaptic endings ultramicroscopically. However, such negative findings should not be generalized.
Furthermore, the question has been dealt with whether the secretory nerve cells connecting the hypothalamus and the hypophysis are innervated. It is pointed out that the pericarya and axons, and possibly also the dendrites, of neurosecretory cells in diencephalic nuclei are covered by synapses. It is still not clear in which nuclei the non-peptidergic fibers originate which are synaptically connected with the peptidergic nerve cells. Concerning this matter reference is made to the investigations by Rothballer (1966).
Die Untersuchungen wurden mit dankenswerter Hilfe der Deutschen Forschungsgemeinschaft durchgeführt.
Herrn Prof. Dr. med. Kurt Goerttler, Freiburg i. Br., zum 70. Geburtstag gewidmet.
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Bargmann, W. (1969). Das neurosekretorische Zwischenhirn-Hypophysensystem und seine synaptischen Verknüpfungen. In: Kappers, J.A. (eds) Neurohormones and Neurohumors. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-25519-3_3
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