Zusammenfassung
Analgetika mit antipyretischer Eigenschaft lassen sich in 3 Gruppen einteilen (Tabelle 1).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literatur
Adams SS (1960) Analgesics — antipyretics. J Pharm (Lond) 12:251–252.
Breddin K (1969) Die Hemmung der Thrombozytenaggregation in vitro und in vivo. Folia Haematol 92:460–469.
Breddin K, Scharrer I, Schepping M (1971) Die Hemmung der Plättchenaggregation mit Acetylsalicylsäure. MMW 113:1284–1292.
Brune K, Alpermann H (1983) Non-acidic pyrazoles: inhibition of prostaglandin production, carrageenan oedema and yeast fever. Agents Actions 13:360–363.
Brune K, Rainsford KD, Wagner K, Peskar BA (1981) Inhibition by anti-inflammatory drugs of prostaglandin production in cultured macrophages. Naunyn-Schmiedebergs Arch Pharmacol 315:269–276.
Collins E (1981) Maternal and fetal effects of acetaminophen and salicylates in pregnancy. Obstet Gynecol 58:57S–62S.
Cranston WI, Rawlins MD (1972) Effects of intracerebral micro-injection of sodium salicylate on temperature regulation in the rabbit. J Physiol 222:257–266.
Carlsson KH, Jurna I (1987) The role of descending inhibition in the antinociceptive effects of the pyrazolone derivatives, metamizol (dipyrone) and aminophenanzone („Pyramidon“). Naunyn-Schmiedebergs Arch Pharmacol 335:154–159.
Carlsson KH, Helmreich J, Jurna I (1987) Activation of inhibition from the periaqueductal grey matter mediates central analgesic effect of metamizol (dipyrone). Pain 27:373–390.
Carlsson KH, Monzel W, Jurna I (1988) Depression by morphine and the non-opioid analgesic agents, metamizol (dipyrone), lysine acetylsalicylate, and paracetamol, of activity in rat thalamus neurones evoked by electrical stimulation of nociceptive afferents. Pain 32:313–326.
Ferreira SH (1972) Prostaglandins, aspirin-like drugs and analgesia. Nature New Biology 240:200–203.
Ferreira SH, Moncada S, Vane JR (1971) Indomethacin and aspirin abolish prostaglandin release from the spleen. Nature New Biology 231:237–239.
Flower RJ (1974) Drugs which inhibit prostaglandin biosynthesis. Pharmacol Rev 26:33–67.
Flower RJ, Blackwell GJ (1976) The importance of phospholipase-A2 in prostaglandin biosynthesis. Biochem Pharmacol 25:285–291.
Flower RJ, Vane JR (1972) Inhibition of prostaglandin synthetase in brain explains the anti-pyretic activity of paracetamol (4-acetamidophenol). Nature 240:410–411.
Flower RJ, Gryglewski RJ, Herbaczynska-Credo K, Vane JR (1972) Effects of anti-inflammatory drugs on prostaglandin biosynthesis. Nature New Biology 238:104–106.
Gebhart GF (1982) Opiate and opioid peptide effects on brain stem neurons: relevance to nociception and antinociceptive mechanisms. Pain 12:93–140.
Gryglewski RJ, Panczenko B, Korbut R, Grodzinska L, Ocetkiewicz A (1975) Corticoste-roids inhibit prostaglandin release from perfused mesenteric blood vessels of rabbit and from perfused lungs of sensitized guinea pig. Prostaglandins 10:343–355.
Handwerker HO (1976) Influences of algogenic substances and prostaglandins on the discharges of myelinated cutaneous nerve fibers identified as nociceptors. Adv Pain Res Ther 1:41–45.
Hirata F, Schiffmann E, Venkatsubamanian K, Salomon D, Axelrod J (1980) A phospholipase A2 inhibitory protein in rabbit neutrophils induces by glucocorticoids. Proc Natl Acad Sci USA 77:2533–2536.
Hong SL, Levine L (1976) Inhibition of arachidonic acid release from cells as the biochemical action of anti-inflammatory corticosteroids. Proc Natl Acad Sci USA 73:1730–1734.
Jurna I, Brune K (1990) Central effect of the non-steroid anti-inflammatory agents, indometacin, ibuprofen and dichlofenac, determined in C fibre-evoked activity in single neurons of the rat thalamus. Pain 41:71–80.
Jurna I, Spohrer B, Bock R (1992) Intrathecal injection of acetylsalicylic acid, salicylic acid and indometacin depresses C fibre-evoked activity in the rat thalamus and spinal cord. Pain 49:249–256.
Levy M (1985) Pharmkokinetik von Metamizolmetaboliten. In: Brune K, Lanz R (Hrsg) 100 Jahre Pyrazolone. Urban & Schwarzenberg, München Wien Baltimore, S 163–166.
Lim RKS (1970) Pain. Annu Rev Physiol 32:269–288.
Meredith TJ, Prescott LF, Vale JA (1986) Why do patients still die from paracetamol poisoning? Br Med J 293:345–346.
Okuyama S, Aihara H (1984) The mode of action of analgesic drugs in adjuvant arthritic rats as an experimental model of chronic inflammatory pain: possible central analgesic action of acidic nonsteroidal antiinflammatory drugs. Jpn J Pharmacol 35:95–103.
Rainsford KD (1978) Stucture-activity relationships of non-steroid anti-inflammatory drugs. 1. Gastric ulcerogenic activity. Agents Actions 8:587–605.
Roth J (1985) Pharmakokinetik und Metabolisierung der Pyrazolinone. In: Brune K, Lanz R (Hrsg) 100 Jahre Pyrazolone. Urban & Schwarzenberg, München Wien Baltimore S 167–180.
Roth GJ, Stanford N, Majerus PW (1975) Acetylation of prostaglandin synthase by aspirin. Proc Natl Acad Sci USA 72:3073–3076.
Schroth HJ, Steinsträßer A, Berberich R, Kloss G (1985) Motilität der ableitenden Harnwege. Änderung der Ausscheidungsphase im Nierensequenzszintigram unter der Wirkung von Metamizol — ein Parameter zur Beurteilung. MMW 127:227–228.
Schaible HG, Schmidt RF (1985) Entladungsverhalten von Rezeptoren mit feinen Afferenzen aus normalen und entzündeten Gelenken: Einfluß von Analgetika und Prostaglandinen. In: Brune K, Lanz R (Hrsg) 100 Jahre Pyrazolone. Urban & Schwarzenberg, München Wien Baltimore, S 87–99.
Shapiro S (1984) Agranulocytoses and pyrazolone. Lancet 1:451–452.
Shen TY (1979) Prostaglandin synthetase inhibitors I. In: Vane JR, Ferreira SH (eds) Antiinflammatory drugs. Handbook of experimental pharmacology, vol 50/II. Springer, Berlin Heidelberg New York, pp 305–347.
Shyu KW, Lin MT (1985) Hypothalamic monoaminergic mechanisms of aspirin-induced analgesia in monkeys. J Neural Transm 62:285–293.
Szczeklik A (1984) Anti-inflammatory drugs and asthma. Int Med 4:6–9.
Szczeklik A, Gryglewski RJ, Czerniawska-Mysik G, Pieton R (1977) Asthmatic attacks induced in aspirin-sensitive patients by diclofenac and naproxen. Br Med J 2:231–232.
Tammisto T, Tigerstedt I (1980) Mild analgesics in postoperative pain. Br J Clin Pharmacol 10:347S–350S.
Vane JR (1971) Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature 231:232–235.
Weithmann KU, Alpermann HG (1985) Biochemical and pharmacological effects of dipyrone and its metabolites in model systems related to arachidonic acid cascade. Arzneimittelforschung 35:947–952.
Winder CV, Wax J, Burr V, Been M, Rosiere CE (1958) A study of pharmacological influences on ultraviolet erythema in guinea pigs. Arch Int Pharmacodyn Ther 116:261–292.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1994 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Jurna, I. (1994). Analgetika mit antipyretischer Wirkung: Klinische Pharmakologie. In: Lehmann, K.A. (eds) Der postoperative Schmerz. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-21762-7_9
Download citation
DOI: https://doi.org/10.1007/978-3-662-21762-7_9
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-21763-4
Online ISBN: 978-3-662-21762-7
eBook Packages: Springer Book Archive