Skip to main content

Analgetika mit antipyretischer Wirkung: Klinische Pharmakologie

  • Chapter
Der postoperative Schmerz

Zusammenfassung

Analgetika mit antipyretischer Eigenschaft lassen sich in 3 Gruppen einteilen (Tabelle 1).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Adams SS (1960) Analgesics — antipyretics. J Pharm (Lond) 12:251–252.

    Article  CAS  Google Scholar 

  2. Breddin K (1969) Die Hemmung der Thrombozytenaggregation in vitro und in vivo. Folia Haematol 92:460–469.

    CAS  Google Scholar 

  3. Breddin K, Scharrer I, Schepping M (1971) Die Hemmung der Plättchenaggregation mit Acetylsalicylsäure. MMW 113:1284–1292.

    CAS  Google Scholar 

  4. Brune K, Alpermann H (1983) Non-acidic pyrazoles: inhibition of prostaglandin production, carrageenan oedema and yeast fever. Agents Actions 13:360–363.

    Article  PubMed  CAS  Google Scholar 

  5. Brune K, Rainsford KD, Wagner K, Peskar BA (1981) Inhibition by anti-inflammatory drugs of prostaglandin production in cultured macrophages. Naunyn-Schmiedebergs Arch Pharmacol 315:269–276.

    Article  PubMed  CAS  Google Scholar 

  6. Collins E (1981) Maternal and fetal effects of acetaminophen and salicylates in pregnancy. Obstet Gynecol 58:57S–62S.

    PubMed  CAS  Google Scholar 

  7. Cranston WI, Rawlins MD (1972) Effects of intracerebral micro-injection of sodium salicylate on temperature regulation in the rabbit. J Physiol 222:257–266.

    PubMed  CAS  Google Scholar 

  8. Carlsson KH, Jurna I (1987) The role of descending inhibition in the antinociceptive effects of the pyrazolone derivatives, metamizol (dipyrone) and aminophenanzone („Pyramidon“). Naunyn-Schmiedebergs Arch Pharmacol 335:154–159.

    PubMed  CAS  Google Scholar 

  9. Carlsson KH, Helmreich J, Jurna I (1987) Activation of inhibition from the periaqueductal grey matter mediates central analgesic effect of metamizol (dipyrone). Pain 27:373–390.

    Article  Google Scholar 

  10. Carlsson KH, Monzel W, Jurna I (1988) Depression by morphine and the non-opioid analgesic agents, metamizol (dipyrone), lysine acetylsalicylate, and paracetamol, of activity in rat thalamus neurones evoked by electrical stimulation of nociceptive afferents. Pain 32:313–326.

    Article  PubMed  CAS  Google Scholar 

  11. Ferreira SH (1972) Prostaglandins, aspirin-like drugs and analgesia. Nature New Biology 240:200–203.

    Article  PubMed  CAS  Google Scholar 

  12. Ferreira SH, Moncada S, Vane JR (1971) Indomethacin and aspirin abolish prostaglandin release from the spleen. Nature New Biology 231:237–239.

    Article  PubMed  CAS  Google Scholar 

  13. Flower RJ (1974) Drugs which inhibit prostaglandin biosynthesis. Pharmacol Rev 26:33–67.

    PubMed  CAS  Google Scholar 

  14. Flower RJ, Blackwell GJ (1976) The importance of phospholipase-A2 in prostaglandin biosynthesis. Biochem Pharmacol 25:285–291.

    Article  PubMed  CAS  Google Scholar 

  15. Flower RJ, Vane JR (1972) Inhibition of prostaglandin synthetase in brain explains the anti-pyretic activity of paracetamol (4-acetamidophenol). Nature 240:410–411.

    Article  PubMed  CAS  Google Scholar 

  16. Flower RJ, Gryglewski RJ, Herbaczynska-Credo K, Vane JR (1972) Effects of anti-inflammatory drugs on prostaglandin biosynthesis. Nature New Biology 238:104–106.

    PubMed  CAS  Google Scholar 

  17. Gebhart GF (1982) Opiate and opioid peptide effects on brain stem neurons: relevance to nociception and antinociceptive mechanisms. Pain 12:93–140.

    Article  PubMed  CAS  Google Scholar 

  18. Gryglewski RJ, Panczenko B, Korbut R, Grodzinska L, Ocetkiewicz A (1975) Corticoste-roids inhibit prostaglandin release from perfused mesenteric blood vessels of rabbit and from perfused lungs of sensitized guinea pig. Prostaglandins 10:343–355.

    PubMed  CAS  Google Scholar 

  19. Handwerker HO (1976) Influences of algogenic substances and prostaglandins on the discharges of myelinated cutaneous nerve fibers identified as nociceptors. Adv Pain Res Ther 1:41–45.

    Google Scholar 

  20. Hirata F, Schiffmann E, Venkatsubamanian K, Salomon D, Axelrod J (1980) A phospholipase A2 inhibitory protein in rabbit neutrophils induces by glucocorticoids. Proc Natl Acad Sci USA 77:2533–2536.

    Article  PubMed  CAS  Google Scholar 

  21. Hong SL, Levine L (1976) Inhibition of arachidonic acid release from cells as the biochemical action of anti-inflammatory corticosteroids. Proc Natl Acad Sci USA 73:1730–1734.

    Article  PubMed  CAS  Google Scholar 

  22. Jurna I, Brune K (1990) Central effect of the non-steroid anti-inflammatory agents, indometacin, ibuprofen and dichlofenac, determined in C fibre-evoked activity in single neurons of the rat thalamus. Pain 41:71–80.

    Article  PubMed  CAS  Google Scholar 

  23. Jurna I, Spohrer B, Bock R (1992) Intrathecal injection of acetylsalicylic acid, salicylic acid and indometacin depresses C fibre-evoked activity in the rat thalamus and spinal cord. Pain 49:249–256.

    Article  PubMed  CAS  Google Scholar 

  24. Levy M (1985) Pharmkokinetik von Metamizolmetaboliten. In: Brune K, Lanz R (Hrsg) 100 Jahre Pyrazolone. Urban & Schwarzenberg, München Wien Baltimore, S 163–166.

    Google Scholar 

  25. Lim RKS (1970) Pain. Annu Rev Physiol 32:269–288.

    Article  PubMed  CAS  Google Scholar 

  26. Meredith TJ, Prescott LF, Vale JA (1986) Why do patients still die from paracetamol poisoning? Br Med J 293:345–346.

    Article  CAS  Google Scholar 

  27. Okuyama S, Aihara H (1984) The mode of action of analgesic drugs in adjuvant arthritic rats as an experimental model of chronic inflammatory pain: possible central analgesic action of acidic nonsteroidal antiinflammatory drugs. Jpn J Pharmacol 35:95–103.

    Article  PubMed  CAS  Google Scholar 

  28. Rainsford KD (1978) Stucture-activity relationships of non-steroid anti-inflammatory drugs. 1. Gastric ulcerogenic activity. Agents Actions 8:587–605.

    Article  PubMed  CAS  Google Scholar 

  29. Roth J (1985) Pharmakokinetik und Metabolisierung der Pyrazolinone. In: Brune K, Lanz R (Hrsg) 100 Jahre Pyrazolone. Urban & Schwarzenberg, München Wien Baltimore S 167–180.

    Google Scholar 

  30. Roth GJ, Stanford N, Majerus PW (1975) Acetylation of prostaglandin synthase by aspirin. Proc Natl Acad Sci USA 72:3073–3076.

    Article  PubMed  CAS  Google Scholar 

  31. Schroth HJ, Steinsträßer A, Berberich R, Kloss G (1985) Motilität der ableitenden Harnwege. Änderung der Ausscheidungsphase im Nierensequenzszintigram unter der Wirkung von Metamizol — ein Parameter zur Beurteilung. MMW 127:227–228.

    Google Scholar 

  32. Schaible HG, Schmidt RF (1985) Entladungsverhalten von Rezeptoren mit feinen Afferenzen aus normalen und entzündeten Gelenken: Einfluß von Analgetika und Prostaglandinen. In: Brune K, Lanz R (Hrsg) 100 Jahre Pyrazolone. Urban & Schwarzenberg, München Wien Baltimore, S 87–99.

    Google Scholar 

  33. Shapiro S (1984) Agranulocytoses and pyrazolone. Lancet 1:451–452.

    Article  PubMed  CAS  Google Scholar 

  34. Shen TY (1979) Prostaglandin synthetase inhibitors I. In: Vane JR, Ferreira SH (eds) Antiinflammatory drugs. Handbook of experimental pharmacology, vol 50/II. Springer, Berlin Heidelberg New York, pp 305–347.

    Google Scholar 

  35. Shyu KW, Lin MT (1985) Hypothalamic monoaminergic mechanisms of aspirin-induced analgesia in monkeys. J Neural Transm 62:285–293.

    Article  PubMed  CAS  Google Scholar 

  36. Szczeklik A (1984) Anti-inflammatory drugs and asthma. Int Med 4:6–9.

    Google Scholar 

  37. Szczeklik A, Gryglewski RJ, Czerniawska-Mysik G, Pieton R (1977) Asthmatic attacks induced in aspirin-sensitive patients by diclofenac and naproxen. Br Med J 2:231–232.

    Article  PubMed  CAS  Google Scholar 

  38. Tammisto T, Tigerstedt I (1980) Mild analgesics in postoperative pain. Br J Clin Pharmacol 10:347S–350S.

    Article  PubMed  Google Scholar 

  39. Vane JR (1971) Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature 231:232–235.

    CAS  Google Scholar 

  40. Weithmann KU, Alpermann HG (1985) Biochemical and pharmacological effects of dipyrone and its metabolites in model systems related to arachidonic acid cascade. Arzneimittelforschung 35:947–952.

    PubMed  CAS  Google Scholar 

  41. Winder CV, Wax J, Burr V, Been M, Rosiere CE (1958) A study of pharmacological influences on ultraviolet erythema in guinea pigs. Arch Int Pharmacodyn Ther 116:261–292.

    PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1994 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Jurna, I. (1994). Analgetika mit antipyretischer Wirkung: Klinische Pharmakologie. In: Lehmann, K.A. (eds) Der postoperative Schmerz. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-21762-7_9

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-21762-7_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-21763-4

  • Online ISBN: 978-3-662-21762-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics