Abstract
The clinical objective of exercising control over the human uterus arises when it becomes desirable either to interrupt the pregnancy or to inhibit parturition. The most obvious examples of these requirements are when the appropriate timing of parturition has been disturbed either by failing to occur at term of pregnancy or by commencing or threatening to commence before term. In both of these circumstances, the welfare of the fetus may be in jeopardy and may ultimately depend on the clinician’s ability to cause it to remain within the uterus while it matures or to bring about its safe expulsion from a hostile environment.
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References
Akerlund M et al. (1985) The effect on the human uterus of two newly developed competitive inhibitors of oxytocin and vasopressin. Acta Obstet Gynaecol Scand 64:499–504
Akerlund M et al. (1987) Inhibition of uterine contractions of premature labour with an oxytocin analogue. Results from a pilot study. Br J Obstet Gynaecol 94: 1040–1044
Barclay CG, Brennand JE, Kelly RW, Calder AA (1993) Interleukin-8 production by the human cervix: Another factor in cervical ripening. Am J Obstet Gynecol 169:625–632
Bell WB (1909) The pituitary body and the therapeutic value of infundibular extract in shock, uterine atony and intestinal paresis. BMJ 2:1609–1613
Benedetti TJ (1983) Maternal complications of parenteral β sympathomimetic therapy for premature labor. Am J Obstet Gynecol 145: 1
Berg G et al. (1982) β adrenergic receptors in human myometrium during pregnancy: changes in the number of receptors after β mimetic treatment. Am J Obstet Gynecol 151: 392–396
Bishop EH (1964) Pelvic scoring for elective induction. Obstet Gynecol 24:266–268
Boissonas RA et al. (1955) A new synthesis of oxytocin. Helvetica Chimica Acta 38:1491–1495
Bygdeman M, Swahn ML (1985) Progesterone receptor blockade: Effect on uterine contractility in early pregnancy. Contraception 32: 45–51
Calder AA (1979) Management of the unripe cervix. In: Anderson ABM, Keirse MJNC (eds) Human parturition: new concepts and developments. Leiden University Press, Leiden
Calder AA (1981) The human cervix in pregnancy: a clinical perspective. In: Ellwood DA, Anderson ABM (eds) The Cervix in Pregnancy and Labour. Clinical and Biochemical Investigations, Edinburgh, Churchill Livingstone, pp 103–122
Calder AA (1983) Methods of induction of labour. In: Studd J (ed) Progress in Obstet Gynaecol, Volume 3: Churchill Livingstone, Edinburgh, pp 145–264
Calder AA (1987) Prostaglandins — their role in labour and labour induction. In: Keirse MJNC, de Koning HJ (eds) Priming and induction of labour by prostaglandins. “ A State of the Art”. Leiden, Boerhaave Cursus, pp 79–86
Calder AA, Greer IA (1991) Pharmacological Modulation of Cervical Compliance in the First and Second Trimesters of Pregnancy. Semin Perinatol 15 (2): 162–172
Calder AA, Greer IA (1992a) Prostaglandins and the cervix. Bailliere’s Clinical Obstet Gynaecol 6:771–786
Calder AA, Greer IA (1992b) Cervical physiology and induction of labour. In: Bonnar J (ed) Recent advances in obstetrics and gynaecology, vol 17. Churchill Livingstone, Edinburgh, pp 33–56
Calder AA, Elder MG (1993) Prostaglandins for cervical ripening and labour induction. In: Vane JR and Grady J (eds) Clinical Application of Prostaglandins. Sevenoaks, Arnold, pp 92–104
Dale HH (1906) On some physiological aspects of ergot. J Physiol 34:163
DuVigneaud V et al. (1953) The sequence of amino acid in oxytocin with a proposal for the structure of oxytocin. J Biol Chem 205:949–955
Frydman R et al. (1991) Mifepristone for induction of labour. Lancet 337:488–489
Ghosh A, Hudson FP (1972) Oxytocic agents and neonatal hyperbilirubinaemia. Lancet ii:823
Gordon AJ, Calder AA (1977) Oestradiol applied locally to ripen the unfavourable cervix. Lancet 2:1319–1321
Greer IA, McLaren M, Calder AA (1990) Plasma prostaglandin E2 and prostaglandin F2α metabolite levels following vaginal administration of prostaglandin E2 for induction of labor. Acta Obstet Gynecol Scand 69:621–625
Hisaw FL (1926) Experimental relaxation of the pubic ligament of the guinea pig. Proceedings of the Society of Exploratory Biological Medicine 23:661–663
Horton EW (1972) Prostaglandins. William Heinemann Medical Books Ltd., London, Springer, Berlin Heidelberg New York
Ito A et al. (1988) Spontaneous production of interleukin-1-like factors from pregnant rabbit uterine cervix. Am J Obstet Gynecol 160:1117–1123
Keirse MJNC (1979) Endogenous prostaglandins in human parturition. In: Keirse MJNC, Anderson A, Bennebroek Gravenhorst J (eds) Human Parturition. Leiden University Press, Leiden, pp 101–142
Keirse MJNC (1992) Inhibitors of prostaglandin synthesis for treatment of preterm labour. In: JO Drife, AA Calder (eds) Prostaglandins and the Uterus. Springer, London, pp 277–296
Kelly RW, Buckman A (1990) Antiprogestagenic inhibition of uterine prostaglandin inactivation: a permissive mechanism for uterine stimulation. J Steroid Biochem Mol Biol 37:97–101
Kelly RW et al. (1992) Choriodecidual production of interleukin-8 and mechanism of parturition. Lancet 339:776–777
Kennedy JH et al. (1982) Induction of labour: a comparison of a single prostaglandin E2 vaginal tablet with amniotomy and intravenous oxytocin. Br J Obstet Gynaecol 89:704–707
King JF et al (1988). Betamimetics in preterm labour: an overview of the randomized controlled trials. Br J Obstet Gynaecol 95:211–222
Lyrenas S et al. (1986) Pharmacokinetics of terbutaline during pregnancy. Eur J Clin Pharmacol 29:619–623
MacLennan AH et al. (1980) Ripening of the human cervix and induction of labour with purified porcine relaxin. Lancet i:220
Mochizuki M, Tojo S (1980) Effect of DHA sulphate on softening and dilatation of the uterine cervix in pregnant women. In: Naftolin F, Stubblefield PG (eds) Dilatation of the uterine cervix. New York, Raven Press, pp 267–286
Moise KJ et al. (1988) Indomethacin in the treatment of premature labour: effects on the fetal ductus arteriosus. New Engl J Med 319 (6):327–331
Moran-Ellis J (1991) Rupture of the membranes in labour. J Obstet Gynaecol 11(Suppl 1):S6–S10
Novy et al. (1990) Shirodkar cerclage in a multifactorial approach to the patient with advanced cervical changes. Am J Obstet Gynecol 162:1412–1420
Pinto RM et al. (1964) Action of oestradiol 17β on the activity of the pregnant human uterus. Am J Obstet Gynecol 88:759–769
Read MD, Wellby DE (1986) The use of calcium antagonist (nifedipine) to suppress preterm labour. Br J Obstet Gynaecol 93:933–937
Rodger MW, Baird DT (1990) Pretreatment with mifepristone (RU 486) reduces interval between prostaglandin administration and expulsion in second trimester abortion. Br J Obstet Gynaecol 97:41–45
Romero R et al. (1990) The role of systemic and intrauterine infection in preterm parturition. In: Garfield RE (ed) Uterine Contractility. New York, Raven Press, pp 319–353
Sherwood OD et al. (1990) Relaxin promotes diverse physiological processes in the pregnant rat. In: Garfield RE (ed) Uterine Contractility. New York, Raven Press, pp 237–252
Speert H (1958) Obstetric and Gynecologic Milestones. New York, Macmillan, pp 518–524
Steer CM, Petrie RH (1977) A comparison of magnesium sulfate and alcohol for the prevention of premature labor. Am J Obstet Gynecol 129:1–4
Turnbull AC, Anderson ABM (1968) Induction of labour; results with amniotomy and oxytocin titration. J Obstet Gynaecol of the Br Commonwealth 75:32–41
Wiqvist N (1979) The use of inhibitors of prostaglandin synthesis in obstetrics. In: Keirse MJNC, Anderson ABM, Bennebroek Gravenhorst J (eds) Human parturition. The Hague, Leiden University Press, pp 189–200
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Calder, A.A. (1994). Therapies for Starting and Stopping Labour. In: Chwalisz, K., Garfield, R.E. (eds) Basic Mechanisms Controlling Term and Preterm Birth. Ernst Schering Research Foundation Workshop, vol 7. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-21660-6_12
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DOI: https://doi.org/10.1007/978-3-662-21660-6_12
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