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Cell Adhesion and Motility

  • Chapter
Signaling and the Cytoskeleton

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Abstract

One of the defining characteristics of living organisms and cells is movement. At the cellu-lar level motility can be defined as directed shape changes. As described in chapter 1, cell shape depends on two factors, adhesion and the cytoskeleton. Thus, cells move by a cycle which is initiated with a cytoskeleton-dependent protrusive activity (1). This protrusion defines the direction of movement, sometimes in response to some extracellular force such as an attractant. Directionality is set through formation of adhesions by the protrusive element (Fig. 4.1) (2). Translo cation of the cell then occurs through contractile and detachment phases, and the cycle is set to repeat. One of the important lessons in studying cell motility, illustrated in Figure 4.2, is that there are wide variations in motility among different types of cells. However, the fundamental molecular mechanisms appear similar in most cases, so the differences may reside in the organization and control of those mechanisms.

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  1. School of Medicine, University of Miami, Miami, Florida, USA

    Kermit L. Carraway & Coralie A. Carothers Carraway

  2. Harvard Medical School, Boston, Massachusetts, USA

    Kermit L. Carraway III

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Carraway, K.L., Carraway, C.A.C., Carraway, K.L. (1998). Cell Adhesion and Motility. In: Signaling and the Cytoskeleton. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-12993-7_4

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  • DOI: https://doi.org/10.1007/978-3-662-12993-7_4

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