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Cell Polarity and Morphology

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Signaling and the Cytoskeleton

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Abstract

Cell responses to stimuli in their environments are sensitive, selective and tem porally or- dered. One of the most frequent responses is an induction of polarity, or asymmetric morphology, in one or more regions of the cell. Establishment and maintenance of cell polarity are requisite to the differentiation and development of organisms and to many cellular functions (1), including cell motility, localized membrane growth, vectorial transport across cell layers and activation of immune response mechanisms. The ultimate morphology of a cell is determined by a progression of events through three temporally ordered stages:

  1. 1)

    determination of the site(s) of origin of the alteration in morphology;

  2. 2)

    establishment of polarity; and

  3. 3)

    maintenance (or reversal) of the polarized state.

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  1. School of Medicine, University of Miami, Miami, Florida, USA

    Kermit L. Carraway & Coralie A. Carothers Carraway

  2. Harvard Medical School, Boston, Massachusetts, USA

    Kermit L. Carraway III

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Carraway, K.L., Carraway, C.A.C., Carraway, K.L. (1998). Cell Polarity and Morphology. In: Signaling and the Cytoskeleton. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-12993-7_3

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