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Signaling Components and Pathways

  • Chapter
Signaling and the Cytoskeleton

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Abstract

The survival of a multicellular organism requires a carefully orchestrated net work of inter-cellular communications which regulate every aspect of growth, metabolic function, differentiation, development and programmed cell death (apoptosis). Cells of both unicellular and multicellular organisms respond to stimuli in their environments in intricately sensitive and selective manners. These responses are temporally ordered, varied and frequently complex, ranging in complexity from sensory signals such as photons of light, to proteins on adjacent cells. Analogously, cellular responses vary significantly from relatively simple modifications of metabolic pathways, to global structural rearrangements affecting the entire cell. In addition to the commonly recognized extracellular stimuli, cells may also respond to intracellular signals (inside-out signaling). Examples of inside-out signaling will be described in subsequent chapters. Chapter 2 will focus largely on the transduction of extracellular signals in the more classical outside-in mode and will describe in general terms the components and general molecular mechanisms for transduction of signals. The objective of this chapter is to acquaint the reader with the most basic aspects of this rapidly expanding field, the concepts, classes of components and molecular mechanisms important in the transduction of signals. Where appropriate, attention will be drawn to the signaling systems or components which have been shown to interact with the cytoskeleton or to regulate its organization. Of necessity, the descriptions will be cursory and review or overview articles will be cited prominently.

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  1. School of Medicine, University of Miami, Miami, Florida, USA

    Kermit L. Carraway & Coralie A. Carothers Carraway

  2. Harvard Medical School, Boston, Massachusetts, USA

    Kermit L. Carraway III

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Carraway, K.L., Carraway, C.A.C., Carraway, K.L. (1998). Signaling Components and Pathways. In: Signaling and the Cytoskeleton. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-12993-7_2

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