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Cell culture of human atheromatous plaque material

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Interventional Cardiology and Angiology

Abstract

Atherosclerosis is an arterial disease that is known to be the main cause of death in Western Europe and in the United States. Consequently, different animal models and experimental designs have been developed to study the progress of this disease. Migration and proliferation of arterial smooth muscle cells from the media into the subendothelial space in response to injury or exposure to potential pathogenic factors are characteristic features in the pathogenesis of atherosclerosis (1–5). Morphology, function and metabolic alteration of endothelial and smooth muscle cells from atherosclerotic arteries of man and of animals have been widely investigated (6, 7). Atheromas contain cells with increased amounts of rough endoplasmatic reticulum and mitochondria, polynuclear and hypertrophied cells (8–12). This investigation describes the isolation of cells from human atheromatous plaque material, their growth in cell culture and characteristic features of these cells.

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Author information

Authors and Affiliations

  1. Institute of Physiology I, University of Tübingen, Germany

    P. C. Dartsch & E. Betz

  2. Department of Medicine I, University of Munich, Germany

    G. Bauriedel & B. Höfling

Authors
  1. P. C. Dartsch
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  2. G. Bauriedel
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  3. B. Höfling
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  4. E. Betz
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Editor information

Editors and Affiliations

  1. Medizinische Klinik I, Klinikum Großhadern, Marchioninistraße 15, 8000, München, Germany

    B. Höfling  & A. v. Pölnitz  & 

  2. Medizinische Klinik I, Klinikum Großhadern Universität München, Marchioninistr. 15, 8000, München 70, Germany

    E. Erdmann

  3. Medizinische Klinik I, Univ. Klinikum Großhadern, Marchioninistr. 70, 8000, München 70, Germany

    G. Steinbeck

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© 1989 Springer-Verlag Berlin Heidelberg

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Dartsch, P.C., Bauriedel, G., Höfling, B., Betz, E. (1989). Cell culture of human atheromatous plaque material. In: Höfling, B., v. Pölnitz, A., Erdmann, E., Steinbeck, G., Strauer, B.E. (eds) Interventional Cardiology and Angiology. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-662-12114-6_15

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  • DOI: https://doi.org/10.1007/978-3-662-12114-6_15

  • Publisher Name: Steinkopff, Heidelberg

  • Print ISBN: 978-3-662-12116-0

  • Online ISBN: 978-3-662-12114-6

  • eBook Packages: Springer Book Archive

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