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Regulation of SMRT and N-CoR Corepressor Function

  • Chapter
Transcriptional Corepressors: Mediators of Eukaryotic Gene Repression

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 254))

Abstract

This review will describe how the functions of transcriptional corepressors are regulated in cells. I will focus primarily on the SMRT (Silencing Mediator of Retinoic acid and Thyroid hormone receptors) and N-CoR (Nuclear hormone receptor Co-Repressor) complexes that mediate repression by the nuclear hormone receptors (Chen and Evans 1995; Hörlein et al. 1995; Sande and Privalsky 1996). Given that these same corepressors also participate in transcriptional repression by a variety of other transcriptional factors, including PLZF, BCL-6, Myo D, CBF-1/RBP-Jk, and ETO, this review will also touch on aspects of transcriptional regulation by non-receptor transcription factors (Dhordain et al. 1997; Hong et al. 1997; Gelmetti et al. 1998; Grignani et al. 1998; Guidez et al. 1998; He et al. 1998; Kao et al. 1998; Lin et al. 1998; Lutterbach et al. 1998; Wong and Privalsky 1998a; Bailey et al. 1999).

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  1. Section of Microbiology, Division of Biological Sciences, University of California at Davis, One Shield Avenue, Davis, CA, 95616, USA

    M. L. Privalsky

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  1. M. L. Privalsky
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  1. Section of Microbiology, Division of Biological Sciences, University of California at Davis, One Shields Avenue, 95616, Davis, CA, USA

    Martin L. Privalsky

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© 2001 Springer-Verlag Berlin Heidelberg

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Privalsky, M.L. (2001). Regulation of SMRT and N-CoR Corepressor Function. In: Privalsky, M.L. (eds) Transcriptional Corepressors: Mediators of Eukaryotic Gene Repression. Current Topics in Microbiology and Immunology, vol 254. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-10595-5_6

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  • DOI: https://doi.org/10.1007/978-3-662-10595-5_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-08709-7

  • Online ISBN: 978-3-662-10595-5

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