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Role of Histone Deacetylase Complexes in the Regulation of Chromatin Metabolism

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Transcriptional Corepressors: Mediators of Eukaryotic Gene Repression

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 254))

Abstract

The pattern of acetylation of conserved lysines at the N-termini of four nucleosomal histone proteins plays an important role in chromatin metabolism, in particular, chromatin assembly, establishment of silenced heterochromatin regions, and local repression of active euchromatin promoters. In this review, we describe from a biochemical and genetic point of view, recent progress in the characterization of enzymes that carry out histone deacetylation. We show that histone deacetylase enzymes display several features that are common among enzymes involved in chromatin metabolism, particularly, apparent redundancy, an essential multisubunit composition, and evolutionary conservation and diversity. We emphasize the role of histone deacetylases in chromatin metabolism and their importance for cell proliferation.

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Authors and Affiliations

  1. Howard Hughes Medical Institute, Division of Nucleic Acid Enzymology, Department of Biochemistry, Robert Wood Johnson Medical School, Piscataway, NJ, 08854, USA

    A. Kuzmichev & D. Reinberg

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  1. A. Kuzmichev
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  1. Section of Microbiology, Division of Biological Sciences, University of California at Davis, One Shields Avenue, 95616, Davis, CA, USA

    Martin L. Privalsky

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Kuzmichev, A., Reinberg, D. (2001). Role of Histone Deacetylase Complexes in the Regulation of Chromatin Metabolism. In: Privalsky, M.L. (eds) Transcriptional Corepressors: Mediators of Eukaryotic Gene Repression. Current Topics in Microbiology and Immunology, vol 254. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-10595-5_2

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  • DOI: https://doi.org/10.1007/978-3-662-10595-5_2

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