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Molecular Mechanisms of Corepressor Function

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Transcriptional Corepressors: Mediators of Eukaryotic Gene Repression

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 254))

Abstract

Biochemical and genetic advances have fully integrated transcriptional control with the chromatin infrastructure within which DNA is packaged. Central to this integration is the recognition that corepressor complexes exist that interact with sequence-specific DNA-binding proteins, methyl-CpG-binding proteins, nucleosomal histones, and the basal transcriptional machinery. The purpose of this chapter is to discuss some of the unifying features of these diverse complexes and propose molecular mechanisms by which they might function.

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    F. D. Urnov, A. P. Wolffe & D. Guschin

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Urnov, F.D., Wolffe, A.P., Guschin, D. (2001). Molecular Mechanisms of Corepressor Function. In: Privalsky, M.L. (eds) Transcriptional Corepressors: Mediators of Eukaryotic Gene Repression. Current Topics in Microbiology and Immunology, vol 254. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-10595-5_1

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