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Phosphorylation of Mammalian eIF4E by Mnk1 and Mnk2: Tantalizing Prospects for a Role in Translation

  • Chapter
Signaling Pathways for Translation

Part of the book series: Progress in Molecular and Subcellular Biology ((PMSB,volume 27))

Abstract

One of the first translation initiation factors shown to be phosphorylated in mitogen-stimulated mammalian cells was eukaryotic translation initiation factor 4E (eIF4E), the mRNA cap-binding protein (Duncan et al. 1987). eIF4E is also phosphorylated in many malignantly transformed cells (Lazaris Karatzas et al. 1990; Frederickson et al. 1991; Rinker Schaeffer et al. 1992; Rosenwald et al. 1993; Graff et al. 1995), and eIF4E overexpression can lead to transformation (De Benedetti and Rhoadsl990; Lazaris Karatzas et al. 1990). In many cell types, eIF4E seems to be limiting for translation initiation (De Benedetti and Rhoads 1990; Mader and Sonenberg 1995). These observations led to the hypothesis that eIF4E is regulated by phosphorylation, that phosphorylation increases translation efficiency, and that increased translation of certain mRNAs can lead to growth and, ultimately, contributes to malignant transformation.

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Authors and Affiliations

  1. Fred Hutchinson Cancer Research Center, P.O. Box 19024, 1100 Fairview Avenue North, A2-025, Seattle, Washington, 98109-1024, USA

    Malathy Mahalingam & Jonathan A. Cooper

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  1. Malathy Mahalingam
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  2. Jonathan A. Cooper
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Editors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, LA, 71130, USA

    Robert E. Rhoads

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© 2001 Springer-Verlag Berlin Heidelberg

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Mahalingam, M., Cooper, J.A. (2001). Phosphorylation of Mammalian eIF4E by Mnk1 and Mnk2: Tantalizing Prospects for a Role in Translation. In: Rhoads, R.E. (eds) Signaling Pathways for Translation. Progress in Molecular and Subcellular Biology, vol 27. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-09889-9_5

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  • DOI: https://doi.org/10.1007/978-3-662-09889-9_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-07505-6

  • Online ISBN: 978-3-662-09889-9

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