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Primäre und sekundäre Prävention

  • Chapter
Management des MAMMAKARZINOMS

Part of the book series: Onkologie ((ONKAKTUELL))

Zusammenfassung

Das normale Brustdrüsengewebe wird durch ein komplexes Zusammenspiel von Steroid-und Proteohormonen reguliert (Braendle u. Schulz 1998; Tabelle 8.1). Proliferation und Funktion werden allerdings nicht nur endokrin, sondern auch auto-und parakrin gesteuert. Eine wesentliche Rolle spielen dabei eine Reihe von Polypeptidwachstumsfaktoren und die durch sie aktivierten intrazellulären Signalwege. Eine Bedeutung dieser Regelkreise für die maligne Transformation und Progression ist bekannt, aber bis heute nicht hinreichend geklärt. Monoklonale Antikörper gegen derartige Wachstumsfaktorrezeptoren, wie z.B. HER2 (human epidermal-growth-factor-receptor 2) werden therapeutisch zunehmend relevant (Cobleigh et al. 1999). Trotz der inzwischen bekannten Vielschichtigkeit hormonaler Regulationen beim Mammakarzinom stützen sich therapeutische und damit auch präventive Ansätze immer noch fast ausschließlich auf die Wechselwirkung zwischen Östrogenen und Gestagenen bzw. deren Antagonisierung (Henderson et al. 1988).

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Authors
  1. U.-S. Albert
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  2. K.-D Schulz
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Editors and Affiliations

  1. Universitätsfrauenklinik, Universität Ulm, Prittwitzstraße 43, D-89075, Ulm, Deutschland

    Rolf Kreienberg  & Tanja Volm  & 

  2. Städt. Kliniken Frankfurt-Höchst Akademisches Lehrkrankenhaus, Universität Frankfurt, Frauenklinik, Gotenstraße 6-8, D-65929, Frankfurt, Deutschland

    Volker Möbus

  3. Untere Kippstraße 21, D-69198, Schriesheim, Deutschland

    Dieter Alt

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Albert, US., Schulz, KD. (2002). Primäre und sekundäre Prävention. In: Kreienberg, R., Volm, T., Möbus, V., Alt, D. (eds) Management des MAMMAKARZINOMS. Onkologie Aktuell . Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-08460-1_8

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