Zusammenfassung
Bei dieser Läsion finden sich Vergrößerungen der Drüsenläppchen mit Vermehrung und Auftreibung der Azini. Diese sind angefüllt mit einem monomorphen Epithel ohne nennenswerte Atypien. Dieses Epithel kann sich zudem über die Läppchen hinaus in die angrenzenden Milchgänge ausbreiten. Die Bezeichnung der Läsion als „Carcinoma in situ“ erfolgte durch Foote u. Stewart (1941), die derartige Veränderungen häufig in der Nachbarschaft invasiver lobulärer Karzinome fanden. Die Klassifikation dieser Veränderungen als Carcinoma in situ bezieht sich vorwiegend auf deren prognostische Bedeutung, die Morphologie der Läsionen zeigt lediglich ein monomorphes (möglicherweise monoklonales) Epithel ohne Atypien, allerdings mit einem Verlust der basalen Epithellage (Abb. 12.1).
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Literatur
Badve S, A’Hern RP, Ward AM et al. (1998) Prediction of local recurrence of ductal carcinoma in situ of the breast using five histological classifications: A comparative study with long follow-up. Human Pathol 29:915–923
Bobrow LG, Happerfield LC, Gregory W.M, Springall RD, Millis RR (1994) The classification of ductal carcinoma in situ and its association with biological markers. Sem Diagn Pathol 11:199–207
Böcker W, Bier B, Freytag G et al. (1992) An immunohistoche-mical study of the breast using antibodies to basal and luminal keratins, alpha smooth muscle actin, vimentin, collagen IV and laminin. Part II: epitheliosis and ductal carcinoma in situ. Virchows Arch. A Pathol Anat 421:323–330
Boyages J, Delaney G, Taylor R (1999) Predictors of local recurrence after treatment of ductal carcinoma in situ. A metaanalysis. Cancer 85: 616–628
Buerger H, Otterbach F, Simon R et al. (1999a) Comparative genomic hybridization of ductal carcinoma in situ of the breast — evidence of multiple genetic pathways. J Path 187:396–402
Buerger H, Otterbach F, Simon R et al. (1999b) Different genetic pathways in the evolution of invasive breast cancer are associated with distinct morphological subtypes. J Path 189: 521–526
Chen T, Sahin A, Aldaz CM (1996) Deletion map of chromosome 16q in ductal carcinoma in situ of the breast: refining a putative tumor suppressor gene region. Cancer Res 56: 5605–5609
De Potter CR, Schelfhout AM, Verbeeck P et al. (1995) HER-2/neu overexpression correlates with extent of disease in large cell ductal carcinoma in situ of the breast. Human Pathol 26: 601–606
European Commission Working Group on Breast Screening Pathology: Sloane JP, Amendoeira I, Apostolikas N et al. (1998) Consistency achieved by 23 European pathologists in categorizing ductal carcinoma in situ of the breast using five classifications. Human Pathol 29:1056–1062
European Commission Working Group on Breast Screening Pathology: Sloane JP, Amendoeira I, Apostolikas N et al. (1999) Consistency achieved by 23 European pathologists from 12 countries in diagnosing breast disease and reporting prognostic features of carcinoma. Virchows Arch 434:3–10
Faverly DRG, Burgers L, Bult P, Holland R (1994) Three dimensional imaging of mammary ductal carcinoma in situ: Clinical implications. Sem Diagn Pathol 11:93–198
Fisher ER, Costantino J, Fisher B, Palekar AS, Paik SM, Suarez CM, Wolmark N (1996) Pathologic findings from the National Surgical Adjuvant Breast Project (NSABP) Protocol B-17. Cancer 78:1403–1416
Fisher ER, Costantino J, Fisher B, Palekar AS, Redmond C, Mamounas E (1995) Pathologic findings from the National Surgical Adjuvant Breast Cancer Project (NSABP) Protocol B-17. Cancer 75:1310–1319
Fisher B, Costantino J, Redmond C et al. (1993) Lumpectomy compared with lumpectomy and radiation therapy for the treatment of intraductal breast cancer. N Engl J Med 328: 1581–1586
Fisher ER, Sass R, Fisher B et al. (1986) Pathologic findings from the National Surgical Adjuvant Breast Project (Protocol 6): I Intraductal carcinoma (DCIS). Cancer 57:197–208
Foote FW Jr, Stewart FW (1941) Lobular carcinoma in situ: a rare form of mammary cancer. Am J Pathol 17:491–496
Fuji H, Szumel R, Marsh C, Zhou W, Gabrielson E (1996) Genetic progression, histological grade and allelic loss in ductal carcinoma in situ of the breast. Cancer Res 56:5260–5265
Gould EW, Robinson PG (1992) The pathologist’s examination of the „lumpectomy“ — the pathologist’s view of surgical margins. Sem Surg Oncol 8:129–135
Haagensen CD, Lane N, Bodian C (1983) Coexisting lobular neoplasia and carcinoma of the breast. Cancer 51:1468–1482
Holland R, Hendriks JHCL (1994) Microcalcifications associated with ductal carcinoma in situ: mammographic-pathologic correlation. Sem Diagn Pathol 11:181–192
Kanthan R, Xiang J, Magliocco AM (2000) p53, ErbB2, and TAG-72 expression in the spectrum of ductal carcinoma in situ of the breast classified by the Van Nuys system. Arch Pathol Lab Med 123: 234–239
Lagios MD (1990) Duct carcinoma in situ: pathology and treatment. Surg Clin N A 70: 853–871
Lagios MD (1995) Ductal carcinoma in situ: controversies in diagnosis, biology, and treatment. Breast J 1: 68–78
Lagios MD, Margolin FR, Westdahl PR, Rose MR (1989) Mam-mographically detected duct carcinoma in situ: Frequency of local recurrence following tylectomy and prognostic effect of nuclear grade on local recurrence. Cancer 63:618–624
Lakhani SR (1999) The transition from hyperplasia to invasive carcinoma of the breast. J Pathol 187:272–278
Lakhani SR, Collins N, Stratton MR, Sloane JP (1995) Atypical ductal hyperplasia of the breast: clonal proliferation with loss of heterozygosity on chromosomes 16q and 17p. J Clin Pathol 48: 611–615
Micale MA, Visscher DW, Gulino SE, Wolman SR (1995) Chromosomal aneuploidy in proliferative breast disease. Human Pathol 25:29–35
Moinfar F, Man YG, Lininger RA, Bodian C, Tavassoli FA (1999) Use of keratin 34ßE12 as an adjunct in the diagnosis of mammary intraepithelial neoplasia-ductal type — benign and malignant intraductal proliferations. Am J Surg Pathol 23: 1048–1058
Moore E, Magee H, Coyne J, Gorey T, Dervan PA (1999) Widespread chromosomal abnormalites in high-grade ductal carcinoma in situ of the breast. Comparative genomic hybridization study of pure high-grade DCIS. J Path 187:403–409
Page DL (1982) Intraductal carcinoma of the breast: Follow-up after biopsy only. Cancer 49:751–758
Page DL, Dupont WD, Rogers LW et al. (1995) Continued local recurrence of carcinoma 15–25 years after diagnosis of low grade ductal carcinoma of the breast treated only by biopsy. Cancer 76:1197–1200
Poller DN, Snead D, Roberts EC et al. (1993) Oestrogen receptor expression in ductal carcinoma in situ of the breast: Relationship to flow cytometric analysis of DNA and expression of the c-erbB-2 oncoprotein. Br J Cancer 68:156–161
Rosen PP (1980) Coexistent lobular carcinoma in situ and intraductal carcinoma in a single lobular-duct unit. Am J Surg Pathol 4: 241–246
Rosen PP, Oberman HA (1992) Tumors of the mammary gland. Atlas of Tumor Pathology Fascicle 7, Third Series, Armed Forces Institute of Pathology, Washington DC
Shoker BS, Sloane JP (1999) DCIS grading schemes and clinical implications. Histopathology 35:393–400
Silverstein MJ, Gierson ED, Colburn WJ et al. (1994) Can intraductal breast carcinoma be excised completely by local excision? Cancer 73: 2985–2989
Silverstein MJ, Lagios MD, Craig PH, Waisman JR, Lewinsky BS, Colburn WJ, Poller DN (1996) A prognostic index for ductal carcinoma in situ of the breast. Cancer 77: 2267–2274
Silverstein MJ, Lagios MD, Groshen S et al. (1999) The influence of margin width on local control of ductal carcinoma in situ of the breast. N Engl J Med 340:1455–1461
Silverstein MJ, Poller DN, Waisman JR et al. (1995) Prognostic classification of breast ductal carcinoma in situ. Lancet 345: 1154–1157
Silverstein MJ, Rosser RJ, Gierson ED et al. (1987) Axillary lymph node dissection for intraductal breast carcinoma — is it indicated ? Cancer 59:1819–1824
Susnik B, Worth A, Palcic B, Poulin N, LeRiche J (1995) Differences in quantitative nuclear features between ductal carcinoma in situ (DCIS) with and without accompanying invasive carcinoma in the surrounding breast. Anal Cell Pathol 8: 39–52
Tulusan AH, Egger H, Schneider ML, Willgeroth F (1982) Lobular carcinoma in situ and its relation to breast cancer. Arch Gynecol 231:219–226
Van Diest PJ (1999) Ductal carcinoma in situ in breast carcinogenesis. J Pathol 187:383–384
Zafrani B, Contesso G, Eusebi V, Holland R, Millis RR, Peterse JL (1995) Guidelines for the pathological management of mammographically detected breast lesions. The Breast 4: 52–56
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Mitze, M. (2002). Management der In-situ-Karzinome. In: Kreienberg, R., Volm, T., Möbus, V., Alt, D. (eds) Management des MAMMAKARZINOMS. Onkologie Aktuell . Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-08460-1_12
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