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Prinzipien der Signaltransduktion

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Biochemie für Mediziner

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Zusammenfassung

Alle Zellen multizellulärer Lebewesen tauschen während der embryonalen Entwicklung, aber auch innerhalb des adulten Organismus ständig Informationen aus. Durch diesen „Datenaustausch“ können Zellen das Verhalten andere Zellen beeinflußen und auf diese Weise den gesamten Organismus den physiologischen Rahmenbedingung anpassen. Welche Moleküle übernehmen diesen Informationsaustausch? Hier sind im wesentlichen drei Familien von Molekülen zu nennen:

  • die Hormone

  • die Neurotransmitter

  • die Wachstumsfaktoren

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Literatur

  1. Beato, M., Herrlich, P., Schütz, G.: Steroid hormone receptors: Many actors in search of a plot. Cell Vol. 83, S. 851 — 857 (1995).

    Google Scholar 

  2. Berg, J. M.: DNA binding specifity of steroid receptors. Cell Vol. 57, S. 1065 — 1068 (1989).

    Google Scholar 

  3. Bredt, D. S., Snyder, S. H.: Nitric oxide: A physiologic messenger molecule. Annu. Rev. Biochem. S 175 —195 (1994).

    Google Scholar 

  4. Cohen, G.B., Ren, R., Baltimore, D.: Modular binding domains in signal transduction proteins, Cell Vol. 80, S. 237–248 (1996).

    Article  Google Scholar 

  5. Fantl, W. J. et al.: Signaling by receptor tyrosine kinases, Annu. Rev. Biochem. 62, S. 453 — 481 (1993).

    Google Scholar 

  6. Heldin, C.-H.: Dimerization of cell surface receptors in signal transduction, Cell Vol. 80, S. 213–223 (1995).

    Article  PubMed  CAS  Google Scholar 

  7. Hill, C.S., Treisman, R.: Transcriptional regulation by extracellular signals: mechanisms and specificity, Cell Vol. 80, 199–211 (1995).

    Article  PubMed  CAS  Google Scholar 

  8. Hunter, T.: Protein kinases and phosphatases: The Yin and Yang of protein phosphorylation and signaling. Cell Vol. 80, S. 225–236 (1995).

    Article  PubMed  CAS  Google Scholar 

  9. Laufs, U., Erdmann, E.: Stickstoffmonoxid als Signalmolekül im Herz-Kreislaufsystem. Dtsch. med. Wschr. 123, S. 1562 — 1565 (1998).

    Google Scholar 

  10. MacMicking, J. et al: Nitric oxide and macrophage function. Annu. Rev. Immunol S 323 — 350 (1997).

    Google Scholar 

  11. Mangelsdorf, D. J. et al.: The nuclear receptor superfamiliy: The second decade. Cell Vol. 83, S. 835 — 839 (1995).

    Google Scholar 

  12. Marietta, M. A.: Nitric oxide synthase: Aspects concerning structure and catalysis. Cell Vol. 78, S. 927 — 930 (1994).

    Google Scholar 

  13. Marshall, C. J.: Specificty of receptor tyrosin kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell Vol. 80, S. 179–185 (1995).

    Article  PubMed  CAS  Google Scholar 

  14. Mortimer, C. E.: Chemie. S. 434 — 435. Thieme Verlag, 6. Auflage (1996).

    Google Scholar 

  15. Nathan, C., Xie, Q.: Nitric oxide synthases: Rolls, tolls, and controls. Cell Vol. 78, S. 915 — 918 (1994).

    Google Scholar 

  16. Neer, E.: Heterotrimeric G-Proteins: Organizers of transmembrane signals. Cell Vol. 80, 249–257 (1995).

    Article  PubMed  CAS  Google Scholar 

  17. Pratt, W. B., Dittmar, K. D.: Studies with purified chaperons advance the understanding of the mechanism of glucocorticoid receptor-hsp 90 heterocomplex assembly. TEM Vol. 9, S. 244 — 252 (1998).

    Google Scholar 

  18. Quon, M. J. et al.: Insulin signal transduction pathways. TEM Vol. 5, S. 369 — 376 (1994).

    Google Scholar 

  19. Rolf, C., Nieschlag, E.: Sildenafil (Viagra°) Bei erektiler Dysfunktion. Dtsch. med. Wschr. 123, S. 1356 —1361 (1998).

    Google Scholar 

  20. Schäffer et al.: Stickstoffmonoxid: Mediator der Gewebsreparation? Dtsch. med. Wschr. 122, S. 339 —345 (1997).

    Google Scholar 

  21. Schmidt, H. W., Walter, U.: NO at work. Cell Vol. 78, S. 919 — 925 (1994).

    Google Scholar 

  22. Stamler, J. S.: Redox signaling: Nitrosylation an related target interactions of nitric oxide. Cell Vol. 78, S. 931 — 936 (1994).

    Google Scholar 

  23. Tonks, N.K., Nell, B. G.: From form to function: signaling by protein tyrosine phosphatases. Cell Vol. 87, S. 365–368 (1996).

    Article  PubMed  CAS  Google Scholar 

  24. Yenush, L., White, M.: The IRS-signaling system during insulin and cytokine action. BioEssays Vol. 19, 491–500 (1997).

    CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Bioscientia Standort Frankfurt, Nibelungenallee 37-41, 60318, Frankfurt-Nordend, Deutschland

    Dr. med. Dipl. Bioch. Markus Linnemann

  2. Abteilung Biochemie, Universität Ulm, Albert-Einstein-Allee 11, 89081, Ulm, Deutschland

    Professor Dr. Michael Kühl

Authors
  1. Dr. med. Dipl. Bioch. Markus Linnemann
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  2. Professor Dr. Michael Kühl
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Linnemann, M., Kühl, M. (2003). Prinzipien der Signaltransduktion. In: Biochemie für Mediziner. Springer-Lehrbuch. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-06057-5_13

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  • DOI: https://doi.org/10.1007/978-3-662-06057-5_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-43673-7

  • Online ISBN: 978-3-662-06057-5

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