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A Neural Primary Genomic Response to the Lipid Mediator Platelet-Activating Factor

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Phospholipids and Signal Transmission

Part of the book series: Nato ASI Series ((volume 70))

Abstract

Platelet-activating factor (PAF; 1–0-alkyl-2-acetyl-sn-3-phosphocholine) is a cell membrane metabolite generated in response to stimulation and, when released from the cell, becomes a potent cell activator. Tissue of the central nervous system is rich in phospholipid PAF precursors. PAF accumulates in brain following seizures and ischemia. Certain PAF antagonists prevent neural cell damage following ischemia, and other PAF antagonists suppress establishment of long-term potentiation. Several cultured neural cells synthesize PAF and retain it intracellularly. A potent PAF antagonist selective for a high-affinity, intracellular PAF binding site in brain suppresses stimulation of neural immediate-early gene expression in vitro and in in vitro. This effect suggests a role for PAF in long-term reparative processes that involve the stimulation of new protein synthesis.

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Authors and Affiliations

  1. LSU Neuroscience Center, LSU Eye Center, New Orleans, Louisiana, 70112, USA

    John P. Doucet & Nicolas G. Bazan

  2. Department of Biochemistry and Molecular Biology, LSU Medical Center, New Orleans, Louisiana, 70112, USA

    John P. Doucet & Nicolas G. Bazan

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  1. John P. Doucet
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  2. Nicolas G. Bazan
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Editors and Affiliations

  1. CNRS, Centre de Neurochimie, Strasbourg, France

    Raphaël Massarelli (Director of Research) (Director of Research)

  2. Department of Medical Biochemistry, College of Medicine, The Ohio State University, Columbus, Ohio, USA

    Lloyd A. Horrocks (Professor Emeritus) (Professor Emeritus)

  3. Department of Biochemistry and Molecular Biology, The University of Manitoba, Winnipeg, Manitoba, Canada

    Julian N. Kanfer (Professor) (Professor)

  4. Department of Pharmacology, University of Mainz, Mainz, Germany

    Konrad Löffelholz (Professor) (Professor)

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© 1993 Springer-Verlag Berlin Heidelberg

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Doucet, J.P., Bazan, N.G. (1993). A Neural Primary Genomic Response to the Lipid Mediator Platelet-Activating Factor. In: Massarelli, R., Horrocks, L.A., Kanfer, J.N., Löffelholz, K. (eds) Phospholipids and Signal Transmission. Nato ASI Series, vol 70. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-02922-0_32

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  • DOI: https://doi.org/10.1007/978-3-662-02922-0_32

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