Abstract
Astroglial cells, in addition to providing mechanical and metabolic support to neurons, interact with neuronal function by binding and metabolizing several types of neuromediators. Glial cells are also involved in processes which are activated by brain injury, such as formation of scar tissue and removal of cell debris after cell death. Responses to injury and participation to inflammatory events are based on the production and release of molecules, such as the eicosanoids and other compounds derived from phospholipid hydrolysis, which are typical mediators of inflammation. Eicosanoids are in fact generated in brain, in various pathological conditions, such as trauma, ischemia and convulsions, following the activated release of arachidonic acid (AA) from cell phospholipids.
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© 1993 Springer-Verlag Berlin Heidelberg
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Petroni, A., Salami, M., Blasevich, M., Galli, C. (1993). Activation of Phospholipid Hydrolysis and Generation of Eicosanoids in Cultured Rat Astroglial Cells by PAF, and Modulation by N-3 Fatty Acids. In: Massarelli, R., Horrocks, L.A., Kanfer, J.N., Löffelholz, K. (eds) Phospholipids and Signal Transmission. Nato ASI Series, vol 70. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-02922-0_31
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DOI: https://doi.org/10.1007/978-3-662-02922-0_31
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