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Biosynthesis of 1-Alkyl-2-Acetyl-sn-Glycero-3-Phosphocholine (Platelet Activating Factor) in Cultured Neuronal and Glial Cells

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Phospholipids and Signal Transmission

Part of the book series: Nato ASI Series ((volume 70))

Abstract

Platelet Activating Factor (PAF; 1-alkyl-2-acetyl-sn-glycero-3-phospho-choline) has been detected in the nervous tissue (Tokumura et al., 1987). In this tissue, much evidence supports the hypothesis that PAF is involved in physiological functions and in pathological situations (for review see Goracci, 1990). In fact, PAF induces neuronal differentiation (Kornecki and Ehrlich, 1988) and the stimulation of chick retina with neurotransmitters led to the production of PAF (Bussolino et al., 1986; Bussoli no et al., 1988a). In addition, PAF levels in brain increased during ischemia and convulsions (Feuerstein and Yue, 1989; Kumar et al., 1988). These observations also support the concept that this lipid mediator may have a role in brain dysfunction.

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Author information

Authors and Affiliations

  1. Istituto di Biochimica e Chimica Medica, Università di Perugia, Via del Giochetto, 06100, Perugia, Italy

    E. Francescangeli, L. Freysz, H. Dreyfus, A. Boila & G. Goracci

  2. Center de Neurochimie, Antenne de Cronenbourg, Strasbourg, France

    L. Freysz & H. Dreyfus

Authors
  1. E. Francescangeli
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  2. L. Freysz
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  3. H. Dreyfus
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  4. A. Boila
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  5. G. Goracci
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Editor information

Editors and Affiliations

  1. CNRS, Centre de Neurochimie, Strasbourg, France

    Raphaël Massarelli (Director of Research) (Director of Research)

  2. Department of Medical Biochemistry, College of Medicine, The Ohio State University, Columbus, Ohio, USA

    Lloyd A. Horrocks (Professor Emeritus) (Professor Emeritus)

  3. Department of Biochemistry and Molecular Biology, The University of Manitoba, Winnipeg, Manitoba, Canada

    Julian N. Kanfer (Professor) (Professor)

  4. Department of Pharmacology, University of Mainz, Mainz, Germany

    Konrad Löffelholz (Professor) (Professor)

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© 1993 Springer-Verlag Berlin Heidelberg

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Francescangeli, E., Freysz, L., Dreyfus, H., Boila, A., Goracci, G. (1993). Biosynthesis of 1-Alkyl-2-Acetyl-sn-Glycero-3-Phosphocholine (Platelet Activating Factor) in Cultured Neuronal and Glial Cells. In: Massarelli, R., Horrocks, L.A., Kanfer, J.N., Löffelholz, K. (eds) Phospholipids and Signal Transmission. Nato ASI Series, vol 70. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-02922-0_29

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  • DOI: https://doi.org/10.1007/978-3-662-02922-0_29

  • Publisher Name: Springer, Berlin, Heidelberg

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