Abstract
Tacrine (9-amino-1,2,3,4-tetrahydroacridine) is a reversible noncompetitive inhibitor of cholinesterases (Shaw and Bentley, 1953; Heilbronn, 1961; Patocka et al., 1976; Bajgar et al., 1979; Marquis, 1990) which has been described to have a marked positive effect in the treatment of patients with Alzheimer’s disease (Summers et al., 1986). Since the attempts to treat such patients with other potent inhibitors of cholinesterases had been less successful or not successful at all, the possibility appears likely that tacrine acts not only by inhibiting cholinesterases, but also by producing some additional pharmacological effects.
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© 1993 Springer-Verlag Berlin Heidelberg
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Tuček, S., Doležal, V. (1993). Tacrine (Tetrahydroaminoacridine) and the Metabolism of Acetylcholine and Choline. In: Massarelli, R., Horrocks, L.A., Kanfer, J.N., Löffelholz, K. (eds) Phospholipids and Signal Transmission. Nato ASI Series, vol 70. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-02922-0_27
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