Abstract
In this paper the actions of the natural 1,2-diacyl-sn-glycerol-3-phosphoserine (PS) on brain cholinergic mechanisms in aging rats will be reviewed. Furthermore, preliminary results, obtained with a 1,3-diacyl-sn-glycerol-2-phosphoserine (PS-S1), will also be presented. PS-S1 represents an interesting tool for investigating the role and mechanism of action of serine phospholipids and may have therapeutic implications.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Amaducci L (1988) Phosphatidyl serine in the treatment of Alzheimer’s disease: results of a multicenter study. Psychopharmacol Bull 24:130–134
Calderini G, Bellini F, Bonetti A, Galbiati E, Rubini R, Zanotti A, Toffano G (1986) Pharmacological properties of phosphatidyl serine in the aging brain: biochemical aspects and therapeutic potential. In: Horrocks LA, Freysz L, Toffano G (eds) Phospholipid research in the nervous system. Biochemical and moleceular pharmacology. Liviana Press, Padova, p 233
Corwin J, Dean RL, Bartus RT, Rotrosen J, Watkins DL (1985) Behavioral effects of phosphatidyl serine in the aged Fisher 344 rats: amelioration of passive avoidance deficits without changes in psychomotor task performance. Neurobiol Aging 8:11–15
Crook TH, Tinkleberg J, Yesavage J, Petrie W, Nunzi MG, Massari DC (1991) Effects of phosphatidylserine in age-associated memory impairment. Neurology 41:644–649
Casamenti F, Mantovani P, Amaducci L, Pepeu G (1979) Effect of phosphatidylserine on acetylcholine output from the cerebral cortex of the rat. J Neurochem 32:529–533
Casamenti F, Scali C., Pepeu G (1991) Phosphatidylserine reverses the age-dependent decrease in cortical acetylcholine release: a microdialysis study. Eur J Pharmacol 194:11–16
Collerton D (1986) Cholinergic function and intellectual decline in Alzheimer’s disease. Neuroscience 19:1–28
Consolo S, Wang JX, Fiorentini F, Vezzani A, Ladinsky H (1986) In vivo and in vitro studies on the regulation of cholinergic neurotransmission in striatum, hippocampus and cortex of aged rats. Brain Res 374:212–218
Damsma G, Lammerts van Bueren D, Westerink BHC, Horn AS (1987) Determination of acetylcholine in the femtomole range by means of HPLC, a post-column enzyme reactor, and electrochemical detection. Chromatographia 24:827–831
Dunnett SB, Whishaw IQ, Jones GH, Bunch ST (1987) Behavioral, biochemical and îhistochemical effects of different neurotoxic amino acids injected into nucleus basal is magnocellularis of rats. Neuroscience 20:653–669
Fibiger HC (1991) Cholinergic mechanisms in learning, memory and dementia: a review of recent evidence. Trends Neurol Sci 14:220–223
Fisher W, Victorin K, Bjorklund A, Williams LR, Varon S and Gage FH (1987) Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor. Nature 329:65–68
Fisher W, Gage FH, Bjorklund (1989) Degenerative changes in forebrain cholinergic nuclei correlate with cognitive impairments in aged rats. European J Neurosci 1:34–40
Geula C., Mesulam MM (1989) Cortical cholinergic fibers in aging and Alzheimer’s disease: a morphometric study. Neuroscience 33:469–476
Giacobini E, Becker R (1988) Current research in Alzheimer therapy. Taylor and Francis, New York, Philadelphia, Washington and London
Gibson GE, Peterson C (1981) Aging decrease oxidative metabolism and the release and synthesis of acetylcholine. J Neurochem 37:78–984
Gibson GE, Peterson C., Jenden DJ (1981) Brain acetylcholine synthesis declines with senescence. Science 213:674–676
Lee MH, Bell RM (1989) Phospholipid functional groups involved in protein kinase C activation, phorbol ester binding, and binding to mixed micelles. J Biol Chem 264:14797–14805
Löffelholz K (1989) Receptor regulation of choline phospholipid hydrolysis. Biochem Pharmacol 38:1543–1549
Meyer EM, St Onge E, Crew FT (1984) Effect of aging on rat cortical presynaptic cholinergic processes. Neurobiol Aging 5:315–317
Pedata F, Slavikova Y, Kotas A and Pepeu G (1983) Acetylcholine release from rat cortical slices during postnatal development and aging. Neurobiol Aging 6:337–339
Pedata F, Giovannelli G, Spignoli G and Pepeu G. (1985) Phosphatidyl serine increases acetylcholine release from cortical slices in aged rats. Neurobiol Aging 6:337–339
Pepeu G (1988) Acetylcholine and brain aging. Pharmacol Res Commum 20:91–97
Pepeu G, Gori G, Bartolini L (1980) Pharmacologic and therapeutic perspectives on dementia: an experimental approach. In: Amaducci L, Davison AN, Antuono P (eds) Aging of the brain and dementia. Raven, New York, p 271
Pepeu G, Di Patre PL, Casamenti F (1990) Spontaneous and drug stimulated recovery of cortical cholinergic function after lesion of the nucleus basal is. In: Steriade M, Biesold D (eds) Brain cholinergic systems. Oxford University Press, Oxford New York Tokyo Toronto, p 357
Price DL, Whitehouse PJ, Struble RG, Coyle JT, Clark AW, Delong MR (1982) Alzheimer’s disease and Down’s syndrome. In: Synex FM, Merril CR (eds) Alzheimer’s disease, Down’s syndrome, and aging.
Price DL, Whitehouse PJ, Struble RG, Coyle JT, Clark AW, Delong MR (1982) Alzheimer’s disease and Down’s syndrome. In: Ann NY Acad Sci 396:145–164
Rusted JM, Warburton DM (1989) Cognitive models and cholinergic drugs. Neuropsychobiol 21:31–36
Sunderland T, Tariot P, Murphy DL, Weingartner H, Mueller EA, Cohen RM (1985) Scopolamine challenges in Alzheimer’s disease. Psychopharmacology 87:247–249
Vannucchi MG, Pepeu G (1987) Effect of phosphatidyl serine on acetylcholine release and content in cortical slices from aging rats. Neurobiol Aging 8:403–407
Vannucchi MG, Casamenti F, Pepeu G (1990) Decrease in acetylcholine release from cortical slices in aged rats: investigations into it reversal by phosphatidyl serine. J Neurochem 55:819–825
Wu CF, Bertorelli R, Sacconi M, Pepeu G, Consolo S (1988) Decrease of brain acetylcholine release in aging freely-moving rats detected by microdialysis. Neurobiol Aging 9:357–361
Zanotti A, Valzelli L, Toffano G (1986) Reversal of scopolamine amnesia by phosphatidyl serine in rats. Psychopharmacology 90:274–275
Zanotti A, Valzelli L, Toffano G (1989) Chronic phosphatidyl serine treatment improves spatial memory and passive avoidance in aged rats. Psychopharmacology 99:316–321
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1993 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Pepeu, G., Casamenti, F., Scali, C. (1993). Phosphatidylserine Reverses the Age-Dependent Decrease in Cortical Acetylcholine Release in the Rat. In: Massarelli, R., Horrocks, L.A., Kanfer, J.N., Löffelholz, K. (eds) Phospholipids and Signal Transmission. Nato ASI Series, vol 70. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-02922-0_21
Download citation
DOI: https://doi.org/10.1007/978-3-662-02922-0_21
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-02924-4
Online ISBN: 978-3-662-02922-0
eBook Packages: Springer Book Archive