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Pathology and Medicine

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Microtubules

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Abstract

Many threads link the study of MT to medicine and pathology. After all, the most specific of MT poisons, colchicine, has been used for centuries in the treatment of gout, and the discovery by Pernice in 1889 [90] of its action on mitosis was the result of studies on its toxicity. The other specific MT poisons, VLB and VCR, have become routinely used, with excellent results, in the treatment of many malignant conditions in man. Last, griseofulvin, used as a fungistatic, also belongs to the group of drugs modifying MT.

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References

  1. Adams, M., Warr, J. R.: Colchicine-resistant mutants of Chlamydomonas rheinhardii. Exp. Cell Res. 71, 473–475 (1972)

    PubMed  CAS  Google Scholar 

  2. Aizelius, B. A., Eliasson, R., Johnsen, Ø., Lindholmer, C.: Lack of dynein arms in immotile human spermatozoa. J. Cell Biol. 66, 225–232 (1975)

    Google Scholar 

  3. Ahn, Y. S., Harrington, W. J., Seelman, R. O., Eytel, C. S.: Vincristine therapy of idiopathic and secondary thrombocytosis. New Engl. J. Med. 291, 376–380 (1974)

    PubMed  CAS  Google Scholar 

  4. Aisner, J., Weiss, H. D., Chang, P., Wiernik, P. H.: Orthostatic hypotension during combination chemotherapy with vincristine (NSC-67574). Cancer Chemother. Rep. 58, 927–930 (1974)

    PubMed  CAS  Google Scholar 

  5. Alarcon-Segovia, D., Ibanez, G., Kerchenobich, D., Rojkind, M.: Treatment of scleroderma by modification of collagen metabolism. A double blind trial with colchicine-placebo. J. Rheumatol. 1 (Suppl.), 97 (1974)

    Google Scholar 

  6. Armstrong, J. G.: Vincristine (NSC-67574) symposium. Summary and prospectives. Cancer Chemother. Rep. 52, 527–535 (1968)

    Google Scholar 

  7. Bandmann, U., Norberg, B., Simmingsköld, G.: Griseofulvin inhibition of polymorphonuclear leucocyte chemotaxis in Boyden chambers. Scand. J. Haemat. 15, 81–87 (1975)

    PubMed  CAS  Google Scholar 

  8. Bartter, F. C., Schwartz, W. B.: The syndrome of inappropriate secretion of antidiuretic hormone. Am. J. Med. 42, 790–806 (1967)

    PubMed  CAS  Google Scholar 

  9. Boxer, L. A., Rister, M., Allen, J. M., Baehner, R. L.: Improvement of Chediak-Higashi leukocyte function by cychc guanosine monophosphate. Blood 49, 9–17 (1977)

    PubMed  CAS  Google Scholar 

  10. Bradley, W. G., Lassman, L. P., Pearce, G. W., Walton, J. N.: The neuromyopathy of vincristine in man. Clinical, electrophysiological and pathological studies. J. Neurol. Sci. 10, 107–132 (1970)

    PubMed  CAS  Google Scholar 

  11. Bremmer, W. J., Paulsen, C. A.: Colchicine and testicular function in Man. New Engl. J. Med. 294, 1384–1385 (1976)

    Google Scholar 

  12. Brinkley, B. R., Fuller, G. M., Highfield, D. P.: Cytoplasmic microtubules in normal and transformed cells in culture. Analysis by tubulin antibody immunofluorescence. Proc. Natl. Acad. Sci. USA 72, 4981–4985 (1975)

    PubMed  CAS  Google Scholar 

  13. Brinkley, B. R., Miller, C. L., Fuseler, J. W., Pepper, D. A., Wible, L. J.: The cytoskeleton and cell transformation in malignancy. Microtubules, microfilaments, and growth properties in vitro. Cancer Bull. 29, 13–15 (1977)

    Google Scholar 

  14. Brune, K., Bucher, K. E. Walz, D.: The avian microcrystal arthritis. II. Central versus peripheral effects of sodium salicylate, acetaminophen and colchicine. Agents and Actions 4, 27–33 (1974)

    CAS  Google Scholar 

  15. Brune, K., Glatt, M.: The avian microcrystal arthritis. III. Invasion and enzyme-release from leukocytes at the site of inflammation. Agents and Actions 4, 95–100 (1974)

    PubMed  CAS  Google Scholar 

  16. Brune, K., Glatt, M.: The avian microcrystal arthritis. IV. The impact of sodium salicylate, acetaminophen and colchicine on leukocyte invasion and enzyme liberation in vivo. Agents and Actions 4, 101–107 (1974)

    PubMed  CAS  Google Scholar 

  17. Brune, K., Graf, P., Glatt, M.: Anti-inflammatory action of colchicine. In: Microtubules and Microtubule Inhibitors (eds.: M. Borgers, M. De Brabander), pp. 471–481. Amsterdam-Oxford: North-Holland 1975

    Google Scholar 

  18. Byers, P. H., Ward, P. A., Kellermeyer, R. W., Naff, G. B.: Complement as a mediator of inflammation in acute gouty arthritis. II. Biological activities generated from complement by the interaction of serum complement and sodium urate crystals. J. Lab. Clin. Med. 81, 761–769 (1973)

    PubMed  CAS  Google Scholar 

  19. Caner, J. E. Z.: Colchicine inhibition of chemotaxis. Arthritis Rheum. 8, 757–764 (1965)

    PubMed  CAS  Google Scholar 

  20. Carmichael, S. M., Eagleton, L., Ayers, C. R.: Orthostatic hypotension during vincristine therapy. Arch. Intern. Med. 126, 290–293 (1970)

    PubMed  CAS  Google Scholar 

  21. Casey, E. B., Jeliffe, A. M., Le Quesne, P. M., Millett, Y. L.: Vincristine neuropathy. Clinical and electrophysiological observations. Brain 96, 69–86 (1973)

    PubMed  CAS  Google Scholar 

  22. Castaing, R., Boget, J. C., Favarel-Garrigues, J. C., Vital, C., Cardinaud, J. P.: Intoxication aiguë mortelle par la colchicine. Bordeaux Méd. 2101–2104 (1968)

    Google Scholar 

  23. Chédiak, M.: Nouvelle anomalie leucocytaire de caractère constitutionel et familial. Rev. Hématol. (Paris) 7, 352–357 (1952)

    Google Scholar 

  24. Choi, S., Simone, J. V., Edwards, C. C.: Effects of vincristine on platelet production. In: Platelets. Production, Function, Transfusion and Storage (eds.: M. G. Baldini, S. H. Ebbe), pp. 51–62. New York: Grune and Stratton 1974

    Google Scholar 

  25. Cutting, H. O.: Inappropriate secretion of antidiuretic hormone secondary to vincristine therapy. Am. J. Med. 51, 269–271 (1971)

    PubMed  CAS  Google Scholar 

  26. Denko, C. W.: Anti-prostaglandin action of colchicine. Pharmacology 13, 219–227 (1975)

    PubMed  CAS  Google Scholar 

  27. D’Agostino, A. N., Jarcho, L. W.: A new neuropathy associated with vincristine (leurocristine) therapy. Clin. Res. 12, 106 (1964)

    Google Scholar 

  28. Dinarello, C. A., Wolff, S. M., Goldfinger, S. E., Dale, D. C., Ailing, D. W.: Colchicine therapy for familial Mediterranean fever: a double-blind trial. New Engl. J. Med. 291, 934–937 (1974)

    PubMed  CAS  Google Scholar 

  29. Dinarello, C. A, Chusid, M. J., Fauci, A. S. Gallin, J. I., Dale, D. C., Wolff, S. M.: Effect of prophylactive colchicine therapy on leukocyte function in patients with familial Mediterranean fever. Arthritis Rheum. 19, 618–622 (1976)

    PubMed  CAS  Google Scholar 

  30. Dittman, W. A., Ward, J. R.: Demecolcine toxicity. A case report of severe hematopoietic toxicity and a review of the literature. Am. J. Med. 27, 519–524 (1959)

    PubMed  CAS  Google Scholar 

  31. Dustin, P.: Intoxication mortelle par la colchicine. Etude histologique et hématologique. Bull. Acad. Roy Méd. Belg. VIe. série 6, 505–529 (1941)

    Google Scholar 

  32. Ertel, N., Omokoku, B., Wallace, S. L.: Colchicine concentrations in leukocytes. Arthritis Rheum. 12, 293 (1969)

    Google Scholar 

  33. Ertel, N. H., Mittler, J. C., Akgun, S., Wallace, S. L.: Radioimmunoassay for colchicine in plasma and urine. Science 193, 233–234 (1976)

    PubMed  CAS  Google Scholar 

  34. Fine, R. N., Clarke, R. R., Shore, N. A.: Hyponatremia and vincristine therapy. Am. J. Dis. Child. 112, 256–259 (1966)

    PubMed  CAS  Google Scholar 

  35. Fine, R. E., Taylor, L.: Decreased actin and tubulin synthesis in 3T3 cells after transformation by SV40 virus. Exp. Cell Res. 102, 162–168 (1976)

    PubMed  CAS  Google Scholar 

  36. Flavin, M., Slaughter, C.: Microtubule assembly and function in Chlamydomonas: inhibition of growth and flagellar regeneration by antitubulins and other drugs and isolation of resistant mutants. J. Bacteriol. 118, 59–120 (1974)

    PubMed  CAS  Google Scholar 

  37. Floersheim, G. L., Brune, K., Seiler, K.: Colchicine in avian sodium urate and calcium pyrophosphate microcrystal arthritis. Agents and Actions 3, 20–23 (1973)

    PubMed  CAS  Google Scholar 

  38. Freed, J. J., Ohlsson-Wilhelm, B. M.: Cultured haploid cells resistant to antitubulins. In: Microtubules and Microtubule Inhibitors (eds.: M. Borgers, M. De Brabander), pp. 367–378. Amsterdam-Oxford: North-Holland 1975

    Google Scholar 

  39. Gaskin, F., Gethner, J. S.: Characterization of the in vitro assembly of microtubules. In: Cell Motiliry (eds.: R. Goldman, T. Pollard, J. Rosenbaum), pp. 1109–1123. Cold Spring Harbor Lab. 1976

    Google Scholar 

  40. Gaskin, F., Litman, D. J., Cantor, C. R., Shelanski, M. L.: The formation of filamentous structures from iodinated neurotubules. J. Supramol. Struct. 3, 39–50 (1975)

    PubMed  CAS  Google Scholar 

  41. Gaultier, M., Bismuth, C., Autret, A., Pillon, M.: Antidiurèse inappropriée après intoxication aiguë par la colchicine. Deux cas. Nouv. Presse Méd. 4, 31–32 (1975)

    Google Scholar 

  42. Gaultier, M., Bismuth, C., Conso, F.: L’aplasie médullaire de la colchicine. A propos de 20 cas. Sang and Toxiques 98, 75–85 (1977)

    Google Scholar 

  43. Gaultier, M., Kanfer, A., Bismuth, C.: Données actuelles sur l’intoxication aiguë par la colchicine. A propos de 23 observations. Ann. Méd. Intern. (Paris) 120, 605–618 (1969)

    CAS  Google Scholar 

  44. Gmachl, E. (ed.): Internationales Symposium Über die Anwendung der Vinca-alkaloide Velbe und Vincristin. Berlin-Wien: Urban und Schwarzenberg 1969

    Google Scholar 

  45. Goldfinger, S. E.: Colchicine for familial Mediterranean fever. New Engl. J. Med. 287, 1302 (1972)

    PubMed  CAS  Google Scholar 

  46. Goldstein, R. C., Schwabe, A. D.: Prophylactic colchicine therapy in familial Mediterranean fever. Ann. Intern. Med. 81, 792–794 (1974)

    PubMed  CAS  Google Scholar 

  47. Goodenough, U. W., St. Clair, H. S.: Bald-2: a mutation affecting the formation of doublet and triplet sets of microtubules in Chlamydomonas reinhardii. J. Cell Biol. 66, 480–491 (1975)

    PubMed  CAS  Google Scholar 

  48. Gooneratne, B. W.: Massive generalized alopecia after poisoning by Gloriosa superba. Brit. Med. J. 5494, 1023–1024 (1966)

    Google Scholar 

  49. Haggard, M. E., Fernback, D. J., Holcomb, T. M., Sutow, W. W., Vietti, T. J., Windmiller, J.: Vincristine in acute leukemia of childhood. Cancer 22, 438–444 (1968)

    PubMed  CAS  Google Scholar 

  50. Harris, E. D. Jr., Hoffman, G. S., Mc Guire, J. L., Strosberg, J. M.: Colchicine: effects upon urinary hydroxyproline excretion in patients with scleroderma. Metabolism 24, 529–536 (1975)

    PubMed  CAS  Google Scholar 

  51. Harris, E. D. Jr., Millis, M.: Treatment with colchicine of the periarticular inflammation associated with sarcoidosis: A need for continued appraisal. Arthritis Rheum. 14, 130–133 (1971)

    PubMed  Google Scholar 

  52. Heaney, D., Derghazarian, C. B., Pintteo, G. F., Ali, M. A. M.: Massive colchicine overdose: a report on the toxicity. Am. J. Med. Sci. 271, 233–238 (1976)

    PubMed  CAS  Google Scholar 

  53. Higashi, O.: Congenital gigantism of peroxidase granules. The first case ever reported of qualitative abnormity of peroxidase. Tohoku J. Exp. Med. 59, 315–332 (1953)

    Google Scholar 

  54. Hildebrand, J., Coërs, S.: Etude clinique, histologique et électrophysiologique des neuropathies associées au traitement par la vincristine. Europ. J. Cancer 1, 51–58 (1965)

    CAS  Google Scholar 

  55. Hirano, A.: Neurofibrillary changes in conditions related to Alzheimer’s disease. In: Alzheimer’s Disease and Related Conditions (eds.: G. E. W. Wolstenholme, M. O’Connor), pp. 185–201. London: Churchill 1970

    Google Scholar 

  56. Hirano, A., Zimmerman, H. M.: Some effects of vinblastine implantation in the cerebral white matter. Lab. Invest. 23, 358–367 (1970)

    PubMed  CAS  Google Scholar 

  57. Hitzig, W. H.: Colchicum-Vergiftung bei einem Kleinkind. 2. Beobachtungen über Blut-bildungs-und Mitosestörungen. Acta Haematol. 21, 170–186 (1959)

    PubMed  CAS  Google Scholar 

  58. Hwang, Y. F., Hamilton, H. E., Sheets, R. F.: Vinblastine-induced thrombocytosis. Lancet 2, 1075–1076 (1969)

    PubMed  CAS  Google Scholar 

  59. Iqbal, K., Wisniewski, H. M., Grundke-Iqbal, I., Korthals, J. K., Terry, R. D.: Chemical pathology of neurofibrils. Neurofibrillary tangles of Alzheimer’s presenile-senile dementia. J. Histochem. Cytochem. 23, 563–569 (1975)

    PubMed  CAS  Google Scholar 

  60. Johnson, I. S., Armstrong, J. G., Gorman, M., Burnett, J. P. Jr.: the Vinca alkaloids: a new class of oncolytic agents. Cancer Res. 23, 1390–1427 (1963)

    PubMed  CAS  Google Scholar 

  61. Kaplan, H.: Further experiences with colchicine in the treatment of sarcoid arthritis. New Engl. J. Med. 268, 761–764 (1963)

    Google Scholar 

  62. Kedar, I., Ravid, M., Sohar, E., Garni, J.: Colchicine inhibition of casein-induced amyloidosis in mice. Israel J. Med. Sci. 10, 787–789 (1974)

    PubMed  CAS  Google Scholar 

  63. Klener, P., Donner, L., Housková, J.: Thrombocytosis in rats induced by vinblastine. Haemostasis 1, 73–78 (1972)

    CAS  Google Scholar 

  64. Klener, P., Dormer, L., Hynčica, V., Šafránková, D.: Possible mechamism of vinblastine-induced thrombocytosis. Scand. J. Haematol. 12, 179–184 (1974)

    PubMed  CAS  Google Scholar 

  65. Krisza, F., Kovacs, Z., Dobay, E.: Effect of vincristine on the megacaryocyte system in mice. J. Med. 4, 12–18 (1973)

    Google Scholar 

  66. Layani, F., Aschkenasy, A., Mouzon, M.: Intoxication aiguë par la colchicine; importantes altérations de la leucopoïèse. Bull. Soc. Méd. Hôp. Paris 63, 10–16 (1947)

    Google Scholar 

  67. Legard, C., Eberlin, A., Caen, J. P.: Vincristine-induced thrombocytosis in the rat. Thrombopoiesis and platelet populations. Path. Biol. 21, 41–45 (1973)

    Google Scholar 

  68. Loo, H., Zittoun, R.: Intoxication aiguë à forme comateuse par la vincristine. Gaz. Méd. Fr. 76, 2693–2698 (1969)

    Google Scholar 

  69. McCarty, D. J.: Urate crystal phagocytosis by polymorphonuclear leukocytes and the effects of colchicine. In: Phagocytic Mechanisms in Health and Disease (eds.: R. C. Williams, H. H. Fudenberg), pp. 107–122. Stuttgart: Georg Thieme 1972

    Google Scholar 

  70. Malawista, S. E.: Colchicine: a common mechanism for its anti-inflammatory and anti-mitotic effects. Arthritis Rheum. 11, 191–197 (1968)

    PubMed  CAS  Google Scholar 

  71. Malawista, S. E.: The action of colchicine in acute gouty arthritis. Arthritis Rheum. 18 (Suppl.) 835–846 (1975)

    PubMed  CAS  Google Scholar 

  72. Malawista, S. E., Andriole, V. T.: Colchicine: anti-inflammatory effect of low doses in a sensitive bacterial system. J. Lab. Clin. Med. 72, 933–942 (1968)

    PubMed  CAS  Google Scholar 

  73. Malawista, S. E., Bensch, K. G.: Human polymorphonuclear leukocytes: demonstration of microtubules and effect of colchicine. Science 156, 521–522 (1967)

    PubMed  CAS  Google Scholar 

  74. Mamou, H.: La Maladie Périodique. Paris: Expansion Sci. Fr. 1956

    Google Scholar 

  75. Marmont, A. M., Damasio, E. E.: Clinical experiences with cy to toxic immunosuppressive treatment of idiopathic thrombocytopenic purpura. Acta Haematol. 46, 74–91 (1971)

    PubMed  CAS  Google Scholar 

  76. Martin, J., Mainwaring, D.: Coma and convulsions associated with vincristine therapy. Brit. Med. J. 4, 782 (1973)

    PubMed  CAS  Google Scholar 

  77. Mathé, G., Kenis, Y.: La Chimiothérapie des Cancers (Leucémies, Hématosarcomes et Tumeurs Solides), 3rd ed. Paris: Expansion Sci. Fr. 1975

    Google Scholar 

  78. Meriwether, W. D.: Vincristine toxicity with hyponatremia and hypochloremia in an adult. Oncology 25, 234–238 (1971)

    PubMed  CAS  Google Scholar 

  79. Minor, P. D., Roscoe, D. H.: Colchicine resistance in mammalian cell line. J. Cell Sci. 17, 381–396 (1975)

    PubMed  CAS  Google Scholar 

  80. Montaldi, D. H., Giambrone, J. P., Courey, N. G., Taefi, P.: Podophyllin poisoning associated with the treatment of condyloma acuminatum: a case report. Am. J. Obst. Gyn. 119, 1130 (1974)

    CAS  Google Scholar 

  81. Nagaratnam, N., de Silva, D. P. K. M., de Silva, N.: Colchicine poisoning following ingestion of Gloriosa superba tubers. Trop. Geograph. Med. 25, 15–17 (1973)

    CAS  Google Scholar 

  82. Nicholson, R. G., Feldman, W.: Hyponatremia in association with vincristine therapy. Canad. Med. Ass. J. 106, 356–357 (1972)

    PubMed  CAS  Google Scholar 

  83. O’Callaghan, M. J., Ekert, H.: Vincristine toxicity unrelated to dose. Arch. Dis. Childh. 51, 289–292 (1976)

    PubMed  Google Scholar 

  84. Oldham, R. K., Pomeroy, T. C.: Vincristine-induced syndrome of inappropriate secretion of antidiuretic hormone. South. Med. J. 65, 1010–1012 (1972)

    PubMed  CAS  Google Scholar 

  85. Oliver, J. M.: Defects in cyclic GMP generation and microtubule assembly in Chediak-Higashi and malignant cells. In: Microtubules and Microtubule Inhibitors (eds.: M. Borgers, De Brabander), pp. 341–354. Oxford-Amsterdam: North-Holland 1975

    Google Scholar 

  86. Oliver, J. M.: Impaired microtubule function correctable by cyclic GMP and cholinergic agonists in the Chediak-Higashi syndrome. Am. J. Path. 85, 395–418 (1976)

    PubMed  CAS  Google Scholar 

  87. Oliver, J. M., Zurier, R. B., Berlin, R. D.: Concanavalin cap formation on polymorphonuclear leukocytes of normal and beige (Chediak-Higashi) mice. Nature (London) 253, 471–473 (1975)

    CAS  Google Scholar 

  88. Oliver, J. M., Zurier, R. B.: Correlation of characteristic abnormalities of microtubule function and granule morphology in Chediak-Higashi syndrome with cholinergic agonists. Studies in vitro in Man and in vivo in beige mouse. J. Clin. Invest. 57, 1239–1247 (1976)

    PubMed  CAS  Google Scholar 

  89. Peterson, E., Murray, M.: Serial observations in tissue cultures on neurotoxic effects of colchicine. Anat. Rec. 154, 401 (1966)

    Google Scholar 

  90. Pernice, B.: Sulla cariocinesi delle cellule epiteliali e dell’endotelio dei vasi della mucosa dello stomaco e dell’intestino, nelle studio della gastroenterite sperimentale (nell’avvelenamento per colchico). Sicil. Med. 1, 265–279 (1889)

    Google Scholar 

  91. Phelps, P.: Polymorphonuclear leukocyte motility in vitro. III. Possible release of a chemotactic substance following phagocytosis of urate crystals by polymorphonuclear leukocytes. Arthritis Rheum. 12, 197–211 (1969)

    PubMed  CAS  Google Scholar 

  92. Phelps, P.: Polymorphonuclear leukocyte mobility in vitro. IV. Colchicine inhibition of the formation of chemotactic activity after phagocytosis of urate crystals. Arthritis Rheum. 13, 1–9 (1970)

    PubMed  CAS  Google Scholar 

  93. Phelps, P.: Appearance of chemotactic activity following intra-articular injection of monosodium urate crystals: effect of colchicine. J. Lab. Clin. Med. 76, 622–631 (1970)

    PubMed  CAS  Google Scholar 

  94. Raff, E. C., Brothers, A. J., Raff, R. A.: Microtubule assembly mutant. Nature (London) 260, 615–616 (1976)

    CAS  Google Scholar 

  95. Rak, K.: Effect of vincristine on platelet production in mice. Brit. J. Haematol. 22, 617–624 (1972)

    CAS  Google Scholar 

  96. Reimann, H. A.: Periodic disease. A probable syndrome including periodic fever, benign paroxysmal peritonitis, cyclic neutropenia and intermittent arthralgia. J. Am. Med. Ass. 136, 239–244 (1948)

    CAS  Google Scholar 

  97. Reimann, H. A.: Colchicine for periodic peritonitis. J. Am. Med. Ass. 231, 64–66 (1975)

    CAS  Google Scholar 

  98. Reiquam, C. W., Prosper, J. C.: Chronic idiopathic thrombocytopenia: treatment with prednisone, 6-mercaptopurine, vincristine, and fresh plasma transfusions. J. Pediatr. 68, 885–889 (1966)

    PubMed  CAS  Google Scholar 

  99. Robbins, E., Gonatas, N.: Histochemical and ultrastructural studies on HeLa cultures exposed to spindle inhibitors with special reference to the interphase cell. J. Histochem. Cytochem. 12, 704 (1964)

    PubMed  CAS  Google Scholar 

  100. Robertson, G. L., Bhoopalam, N., Zelkowitz, L. J.: Vincristine neurotoxicity and abnormal secretion of antidiuretic hormone. Arch. Intern. Med. 132, 717–722 (1973)

    PubMed  CAS  Google Scholar 

  101. Robertson, J. H., Crozier, E. H., Woodend, B. E.: The effect of vincristine on the platelet count in rats. Brit. J. Haematol. 19, 331–337 (1970)

    CAS  Google Scholar 

  102. Robertson, J. H., Crozier, E. H., Woodend, B. E.: Vincristine-induced thrombocytosis studied with 75Se selenomethionine. Acta Haematol. 47, 356–360 (1972)

    PubMed  CAS  Google Scholar 

  103. Rojkind, M., Kershenobich, D.: Effect of colchicine on collagen, albumin and transferrin synthesis by cirrhotic rat liver slices. Bioch. Biophys. Acta 378, 415–423 (1975)

    CAS  Google Scholar 

  104. Rojkind, M., Uribe, M., Kershenobich, D.: Colcnicine and the treatment of liver cirrhosis. Lancet I, 38–39 (1973)

    Google Scholar 

  105. Rosenthal, S., Kaufman, S.: Vincristine neurotoxicity. Ann. Intern. Med. 80, 733–737 (1974)

    PubMed  CAS  Google Scholar 

  106. Sandier, S. G., Tobin, W., Henderson, E. S.: Vincristine-induced neuropathy: a clinical study of fifty leukemic patients. Neurology 19, 367–374 (1969)

    Google Scholar 

  107. Sartorelli, A. C., Johns, D. G. (eds.): Antineoplastic and immunosuppressive agents, Part. 2. In: Handbuch der experimentellen Pharmakologie (new series) 38/2 (eds.: O. Eichler, A. Farah, H. Herken, A. D. Welch). Berlin-Heidelberg-New York: Springer 1975

    Google Scholar 

  108. Sato, C.: A conditional cell division mutant of Chlamydomonas reinhardii having an increased level of colchicine resistance. Exp. Cell Res. 101, 251–259 (1976)

    PubMed  CAS  Google Scholar 

  109. Schochet, S. S. Jr., Lampert, P. W., Earle, K. M.: Neuronal changes induced by intrathecal vincristine sulfate. J. Neuropathol. Exp. Neurol. 27, 645–658 (1968)

    PubMed  Google Scholar 

  110. Secret, C. J., Hadfield, J. R., Beer, C. T.: Studies on the binding of (3H) vincristine by rat blood platelets in vitro. Effects of colchicine and vincristine. Biochem. Pharmacol. 21, 1609–1624 (1972)

    PubMed  CAS  Google Scholar 

  111. Selawry, O. S., Holland, J. F., Wolman, I. J.: Effect of vincristine (NSC-67574) on malignant solid tumors in children. Cancer Chem. Rep. 52, 497–500 (1968)

    CAS  Google Scholar 

  112. Shelanski, M. L., Wisniewski, H.: Neurofibrillary degeneration induced by vincristine therapy. Arch. Neurol. 20, 199 –206 (1969)

    PubMed  CAS  Google Scholar 

  113. Shirahama, T., Cohen, A. S.: Ultrastructural evidence for leakage of lysosomal contents after phagocytosis of monosodium urate crystals: a mechanism of gouty inflammation. Am. J. Path. 76, 501–520 (1974)

    PubMed  CAS  Google Scholar 

  114. Shirahama, T., Cohen, A. S.: Blockage of amyloid induction by colchicine in an animal model. J. Exp. Med. 140, 1102–1107 (1974)

    PubMed  CAS  Google Scholar 

  115. Slater, L. M., Wainer, R. A., Serpick, A. A.: Vincristine neurotoxicity with hyponatremia. Cancer 23, 122–125 (1969)

    PubMed  CAS  Google Scholar 

  116. Slonim, R. R., Howell, D. S., Brown, H. E. Jr.: Influence of griseofulvin upon acute gouty arthritis. Arthritis Rheum. 5, 397–404 (1962)

    PubMed  CAS  Google Scholar 

  117. Stemmermann, G. N., Hayashi, T.: Colchicine intoxication. A reappraisal of its pathology based on a study of three fatal cases. Human Path. 2, 321–332 (1971)

    CAS  Google Scholar 

  118. Stuart, M. J., Cuaso, C., Miller, M., Oski, F. A.: Syndrome of recurrent increased secretion of antidiuretic hormone following multiple doses of vincristine. Blood 45, 315–320 (1975)

    PubMed  CAS  Google Scholar 

  119. Sullivan, M. P.: Vincristine (NSC-67574) therapy for Wilms’ tumor. Cancer Chem. Rep. 52, 481–484 (1968)

    CAS  Google Scholar 

  120. Suskind, R. M., Brusilow, S. W., Zehr, J.: Syndrome of inappropriate secretion of antidiuretic hormone by vincristine toxicity (with bioassay of ADH level). J. Pediatr. 81, 90–91 (1972)

    PubMed  CAS  Google Scholar 

  121. Terry, R. D.: Neuronal fibrous protein in human pathology. J. Neuropath. Exp. Neurol. 30, 8–19 (1971)

    PubMed  CAS  Google Scholar 

  122. Tobin, W., Sandier, S. G.: Neurophysiologic alterations induced by vincristine (NSC-67574) Cancer Chem. Rep. 52, 519–526 (1968)

    CAS  Google Scholar 

  123. Valeriote, F., van Putten, L.: Proliferation-independent cytotoxicity of anticancer agents: a review. Cancer Res. 35, 2619–2630 (1975)

    PubMed  CAS  Google Scholar 

  124. Wakem, C. J., Bennett, J. M.: Inappropriate ADH secretion associated with massive vincristine overdosage. Aust. N. Zeal J. Med. 5, 266–269 (1975)

    CAS  Google Scholar 

  125. Wallace, S. L.: Trimethylcolchicinic acid in the treatment of acute gout. Ann. Intern. Med. 54, 274–279 (1961)

    PubMed  CAS  Google Scholar 

  126. Wallace, S. L.: Colchicine and new antiinflammatory drugs in the treatment of gout. Arthritis Rheum. 18 (Suppl.) 847–852 (1975)

    PubMed  CAS  Google Scholar 

  127. Wallace, S. L., Bernstein, D., Diamond, H.: Diagnostic value of the colchicine therapeutic trial. J. Am. Med. Ass. 199, 525–528 (1967)

    CAS  Google Scholar 

  128. Wallace, S. L., Ertel, N. H.: Preliminary report: Plasma levels of colchicine after oral administration of a single dose. Metabolism 22, 749–754 (1973)

    PubMed  CAS  Google Scholar 

  129. Wallace, S. L., Nissen, A. W.: Griseofulvin in acute gout. New Engl. J. Med. 266, 1099 to 1101 (1962)

    PubMed  CAS  Google Scholar 

  130. Weiss, H. D., Walker, M. D., Wiernik, P. H.: Neurotoxicity of commonly used antineoplastic agents. New Engl. J. Med. 291, 75–81; 127–133 (1974)

    PubMed  CAS  Google Scholar 

  131. Whittaker, J. A., Parry, D. H., Bunch, C., Weatherall, D. J.: Coma associated with vincristine therapy. Brit. Med. J. 10, 335–336 (1973)

    Google Scholar 

  132. Wisniewski, H., Karczewski, W., Wisniewska, K.: Neurofibrillary degeneration of nerve cells after intracerebral injection of aluminium cream. Acta Neuropathol. 6, 211–219 (1966)

    PubMed  CAS  Google Scholar 

  133. Wisniewski, H., Shelanski, M. L., Terry, R. D.: Experimental colchicine encephalopathy. I. Induction of neurofibrillary degeneration. Lab. Invest. 17, 577–587 (1967)

    PubMed  CAS  Google Scholar 

  134. Wisniewski, H., Terry, R. D.: An experimental approach to the morphogenesis of neurofibrillary degeneration and the argyrophilic plaque. In: Alzheimer’s Disease and Related Conditions (eds.: G. E. W. Wolstenholme, M. O’Connor), pp. 223–240. London: Churchill 1970

    Google Scholar 

  135. Wisniewski, Terry, R. D.: Neurofibrillary pathology. J. Neuropath. Exp. Neurol. 19, 163–176 (1970)

    Google Scholar 

  136. Zbinden, G., Hégélé, M., Grimm, L.: Toxicological effects of vincristine sulfate on blood platelets. Agents and Actions 2, 241–245 (1972)

    PubMed  CAS  Google Scholar 

  137. Zemer, D., Revach, M., Pras, M., Modan, B., Schor, S., Sohar, E., Gafni, J.: Colchicine to prevent attacks of familial Mediterranean fever. New Engl. J. Med. 291, 932–933 (1974)

    PubMed  CAS  Google Scholar 

  138. Zurier, R. B., Weissmann, G., Hoffstein, S.: Mechanisms of lysosomal enzyme release from human leukocytes. II. Effects of cAMP and cGMP, autonomic agonists, and agents which affect microtubule function. J. Clin. Invest. 53, 297–309 (1974)

    PubMed  CAS  Google Scholar 

  139. Zweig, M. H., Maling, H. M., Webster, M. E.: Inhibition of sodium urate-induced rat hindpaw edema by colchicine derivatives: correlation with antimitotic activity. J. Pharmacol. Exp. Ther. 182, 344–350 (1972)

    PubMed  CAS  Google Scholar 

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  1. Laboratoires d’Anatomie Pathologique et de Microscopie Electronique, Université Libre de Bruxelles, rue aux Laines 97, Bruxelles, B-1000, Belgium

    Prof. Dr. Pierre Dustin

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© 1978 Springer-Verlag Berlin · Heidelberg

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Dustin, P. (1978). Pathology and Medicine. In: Microtubules. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-96436-7_13

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  • DOI: https://doi.org/10.1007/978-3-642-96436-7_13

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