Skip to main content
SpringerLink
Log in

Neurotubules: Neuroplasmic Transport, Neurosecretion, Sensory Cells

  • Chapter
Microtubules

  • 88 Accesses

Abstract

The MT of neurons, or “neurotubules ”, were observed in 1956 by Palay [121] and are a constituent of all nerve cells, in invertebrates and vertebrates. As described in Chapter 2, brain has become one of the favorite sources of tubulin for biochemical studies, and this can be readily understood in view of the large number of MT in dendrites and axons. The MT of glial cells, in the central nervous system and in the nerves, may be associated with some complex structures, such as the Ranvier nodes and the Schmidt-Lanterman incisures (cf. Chap. 6).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 74.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Allison, A. C.: Function and Structure of Cell Components in Relation to Action of Anaesthetics. (eds.: T. C. Gray, J. F. Nunn) General Anaesthesia, Vol. 1. London: Butterworths 1971

    Google Scholar 

  2. Allison, A. C., Nunn, J. F.: Effects of general anaesthetics on microtubules: a possible mechanism of anaesthesia? Lancetii, 1326–1329 (1968)

    Google Scholar 

  3. Ambron, R. T., Goldman, J. E., Schwartz, J. H.: Axonal transport of newly synthetized glycoproteins in a single identified neuron ofAplysia californica. J. Cell Biol.61, 665–675 (1974)

    PubMed  CAS  Google Scholar 

  4. Anderson, K. E., Edström, A., Hanson, M.: Heavy water reversibly inhibits fast axonal transport of proteins in frog sciatic nerves. Brain Res.43, 299–302 (1972)

    PubMed  CAS  Google Scholar 

  5. Atema, J.: Microtubule theory of sensory transduction. J. Theor. Biol.38, 181–190 (1973)

    PubMed  CAS  Google Scholar 

  6. Atema, J.: Stimulus transmission along microtubules in sensory cells: a hypothesis. In: Microtubules and Microtubule Inhibitors (eds.: M. Borgers, M. De Brabander), pp. 247–257. Amsterdam-Oxford: North-Holland 1975

    Google Scholar 

  7. Barondes, S. H.: Slow and rapid transport of protein to nerve endings in mouse brain. Acta Neuropath. Suppl.5, 97–103 (1971)

    Google Scholar 

  8. Bennett, T., Cobb, J. L. S., Malmfors, T.: Fluorescence histochemical and ultrastructural observations on the effects of intravenous injections of vinblastine on noradrenergic nerves. Z. Zeilforsch.141, 517–528 (1973)

    CAS  Google Scholar 

  9. Bergland, R. M., Tocack, R. M.: Microtubules and neurofilaments in axons of human pituitary stalk. Exp. Cell Res.54, 132–134 (1971)

    Google Scholar 

  10. Berlinrood, M., McGee-Russel, S. M., Allen, R. D.: Patterns of particle movements in nerve fibers “in vitro”. J. Cell Sci.11, 875–886 (1972)

    PubMed  CAS  Google Scholar 

  11. Bertolini, B., Monaco, G., Rossi, A.: Ultrastructure of a regular arrangement of microtubules and neurofilaments. J. Ultrastruct. Res.33, 173–186 (1970)

    PubMed  CAS  Google Scholar 

  12. Bird, M. M.: Microtubule-synaptic vesicle associations in cultured rat spinal cord neurons. Cell Tissue Res.168, 101–116 (1976)

    PubMed  CAS  Google Scholar 

  13. Bondy, S. C., Madsen, C. J.: Development of rapid axonal flow in the chick embryo. J. Neurobiol.2, 279–286 (1971)

    PubMed  CAS  Google Scholar 

  14. Bunge, R., Bunge, M.: Electron microscopic observations on colchicine-induced changes in neuronal cytoplasm. Anat. Rec.160, 323 (1968)

    Google Scholar 

  15. Bunt, A. H.: Effects of vinblastine on microtubule structure and axonal transport in ganglion cells of the rabbit retina. Investig. Ophthalmol.12, 579–590 (1973)

    CAS  Google Scholar 

  16. Bunt, A. H., Lund, R. D.: Vinblastine-induced blockage of orthograde and retrograde axonal transport of protein in retinal ganglion cells. Exp. Neurol.45, 288–297 (1974)

    PubMed  CAS  Google Scholar 

  17. Bunt, A. H., Lund, R. D., Lund, J. S.: Retrograde axonal transport of horse-radish peroxidase by ganglion cells of the albino rat retina. Brain Res.73, 215–228 (1974)

    PubMed  CAS  Google Scholar 

  18. Burton, P. R., Fernandez, H. L.: Delineation by lanthanum staining of filamentous elements associated with the surfaces of axonal microtubules. J. Cell Sci.12, 567–584 (1973)

    PubMed  CAS  Google Scholar 

  19. Burton, P. R., Hinkley, R. E.: Further electron microsœpic characterization of axoplasmic microtubules of the ventral nerve cord of the crayfish. J. Submicrosc. Cytol.6, 311–326 (1974)

    Google Scholar 

  20. Byers, M. R.: Structural correlates of rapid axonal transport: evidence that microtubules may not be directly involved. Brain Res.75, 97–114 (1974)

    PubMed  CAS  Google Scholar 

  21. a. Byers, M. R., Hendrickson, A. E., Fink, B. R., Kennedy, R. D., Middaugh, M. E.: Effects of lidocaine on axonal morphology, microtubules and rapid transport in rabbit vagus nerve in vitro. J. Neurobiol.4, 125–143 (1973)

    PubMed  CAS  Google Scholar 

  22. Calissano, P., Levi, A., Alema, S., Chen, J., Levi-Montalcini, R.: Studies on the interaction of the nerve growth factor with tubulin and actin. In: Molecular Basis of Motility (eds.: L. M. G. Heilmeyer, J. C. Ruegg, T. Wieland), pp. 186–202. Berlin-Heidelberg-New York: Springer 1976

    Google Scholar 

  23. Cardinali, D. P., Freire, F.: Melatonin effects on brain. Interaction with microtubule protein, inhibition of fast axoplasmic flow and induction of crystalloid and tubular formations in the hypothalamus. Mol. Cell. Endocrin.2, 317–330 (1975)

    CAS  Google Scholar 

  24. Chang, C.: Effect of colchicine and cytochalasin B on axonal particle movement and outgrowth in vitro. J. Cell Biol.55, 37 a (1972)

    Google Scholar 

  25. Cronly-Dillon, J., Carden, D., Birks, C.: The possible involvement of brain microtubules in memory fixation. J. Exp. Biol.61, 443–454 (1974)

    PubMed  CAS  Google Scholar 

  26. Crothers, S. D., McCluer, R. H.: Effect of colchicine on the delayed appearance of labelled protein into synaptosomal soluble proteins. J. Neurochem.24, 209–214 (1975)

    PubMed  CAS  Google Scholar 

  27. Dahlström, A.: Effect of colchicine on transport of amine storage granules in sympathetic nerves of rat. Europ. J. Pharmacol.5, 111–113 (1968)

    Google Scholar 

  28. Dahlström, A.: The effects of drugs on axonal transport. In: New Aspects of Storage and Release Mechanisms of Catecholamines. Bayer Symposium 2, 20–36. Berlin-Heidelberg-New York: Springer 1970

    Google Scholar 

  29. Dahlström, A.: Axoplasmic transport (with particular respect to adrenergic neurons). Phil. Trans. Roy. Soc. London B261, 325–358 (1971)

    PubMed  Google Scholar 

  30. Dahlström, A., Häggendal, J.: Studies on the transport and life-span of amine storage granules in a peripheral adrenergic neuron system. Acta Physiol. Scand.67, 278–288 (1966)

    PubMed  Google Scholar 

  31. Dahlström, A., Häggendal, J.: Axonal transport of amine storage granules in sympathetic adrenergic neurons. In: Biochemistry of Simple Neuronal Models (eds.: E. Costa, E. Giocobini) Adv. in Bioch. Psychopharmacol. Vol. 2, pp. 65–93. New York: Raven Press; Amsterdam: North-Holland 1970

    Google Scholar 

  32. Dahlström, A., Heiwall, P. O., Häggendal, J., Saunders, N. R.: Effect of antimitotic drugs on the intraaxonal transport of neurotransmitters in rat adrenergic and cholinergic nerves. Ann. N. Y. Acad. Sci.253, 507–516 (1975)

    PubMed  Google Scholar 

  33. Daniels, M. P.: Fine structural changes in neurons in nerve fibers associated with colchicine inhibition of nerve fiber formation in vitro. J. Cell Biol.58, 463–469 (1973)

    PubMed  CAS  Google Scholar 

  34. Davison, P. F.: Axoplasmic transport: physical and chemical aspects. In: Neurosciences, Second Study Program (ed.: F. O. Schmitt), pp. 851–857. New York: Rockefeller University Press 1970

    Google Scholar 

  35. Dentier, W. L., Granett, S., Rosenbaum, J. L.: Ultrastructural localization of the high molecular weight proteins associated with in vitro-assembled microtubules. J. Cell Biol.65, 237–241 (1975)

    Google Scholar 

  36. Douglas, W. W., Sorimachi, M.: Colchicine inhibits adrenal medullary secretion evoked by acetylcholine without affecting that evoked by potassium. Brit. J. Pharmacol.45, 129–132 (1972)

    CAS  Google Scholar 

  37. Dravid, A. R., Hammerschlag, R.: Axoplasmic transport of proteins in vitro in primary afferent neurons of frog spinal cord: Effect of Ca++-free incubation conditions. J. Neurochem.24, 711–718 (1975)

    PubMed  CAS  Google Scholar 

  38. Droz, B., Rambourg, A., Koenig, H.: The smooth endoplasmic reticulum: structure and role in the renewal of axonal membrane and synaptic vesicles by fast axonal transport. Brain Res.93, 1–13 (1975)

    PubMed  CAS  Google Scholar 

  39. Dustin, P., Hubert, J. P., Flament-Durand, J.: Action of colchicine on axonal flow and pituicytes in the hypothalamopituitary system of the rat. Ann. N. Y. Acad. Sci.253, 670–684 (1975)

    PubMed  CAS  Google Scholar 

  40. Edström, A., Hansson, H. A., Norström, A.: Inhibition of axonal transport in vitro in frog sciatic nerves by chlorpromazine and hdocaine. A biochemical and ultrastructural study. Z. Zellforsch.143, 53–70 (1973)

    PubMed  Google Scholar 

  41. Elam, J. S., Goldberg, J. M., Radin, N. S., Agranoff, B. W.: Rapid axonal transport of sulfated mucopolysaccharide proteins. Science170, 458–460 (1970)

    PubMed  CAS  Google Scholar 

  42. Engelborghs, Y., Heremans, K. A. H., Hoebeke, J.: The effect of pressure on neuronal microtubules. In: Microtubules and Microtubule Inhibitors (eds.: M. Borgers, M. De Brabander), pp. 59–66. Amsterdam-Oxford: North-Holland 1975

    Google Scholar 

  43. Engelborghs, Y., Heremans, K. A. H., De Maeyer, L. C. M., Hoebeke, J.: Effect of temperature and pressure on polymerisation equilibrium of neuronal microtubules. Nature259, 686–688 (1976)

    PubMed  CAS  Google Scholar 

  44. Feit, H., Dutton, G. R., Barondes, S. H., Shelanski, M. L.: Microtubule protein. Identification in and transport to nerve endings. J. Cell Biol.51, 138–147 (1971)

    PubMed  CAS  Google Scholar 

  45. Fernandez, H. L., Burton, P. R., Samson, F. E.: Axoplasmic transport in the crayfish nerve cord. The role of fibrillar constituents of neurons. J. Cell Biol.51, 176–192 (1971)

    PubMed  CAS  Google Scholar 

  46. Fernandez, H. L., Huneeus, F. C., Davison, P. F.: Studies on the mechanism of axoplasmic transport in the crayfish cord. J. Neurobiol.1, 395–409 (1970)

    PubMed  CAS  Google Scholar 

  47. Fink, B. R., Kennedy, R. D.: Rapid axonal transport: effect of halothane anesthaesia. Anesthesiology36, 13–20 (1972)

    PubMed  CAS  Google Scholar 

  48. Flament-Durand, J., Couck, A. M., Dustin, P.: Studies on the transport of secretory granules in the magnocellular hypothalamic neurons of the rat. II. Action of vincristine on axonal flow and neurotubules in the paraventricular and supraoptic nuclei. Cell Tissue Res.164, 1–9 (1975)

    PubMed  CAS  Google Scholar 

  49. Flament-Durand, J., Dustin, P.: Studies on the transport of secretory granules in the magnocellular hypothalamic neurons. I. Action of colchicine on axonal flow and neurotubules in the paraventricular nuclei. Z. Zellforsch.130, 440–454 (1972)

    PubMed  CAS  Google Scholar 

  50. Forman, D. S., Padjen, A. L., Siggins, G. R.: Movements of optically detectable intraaxonal organelle in vitro. J. Cell Biol.67, 119 a (1975)

    Google Scholar 

  51. Friede, R. L., Ho, K. C.: The relation of axonal transport of mitochondria with microtubules and other axoplasmic organelles. J. Physiol.265, 507–519 (1977)

    PubMed  CAS  Google Scholar 

  52. Friede, R., Samorajski, T.: Axon caliber related to neurofilaments and microtubules in sciatic nerves of rats and mice. Anat. Rec.167, 379–387 (1970)

    PubMed  CAS  Google Scholar 

  53. Gaffai, K. P., Bassemir, U.: Vergleichende Untersuchung modifizierter Cilienstrukturen in den Dendriten mechano- und chemosensitiver Rezeptorzellen der BaumwollwanzeDysdercus und der LibelleAgrion. Protoplasma82, 177–202 (1974)

    Google Scholar 

  54. Gainer, H., Same, Y., Brownstein, M. J.: Biosynthesis and axonal transport of rat neurohypophysial proteins and peptides. J. Cell Biol.73, 366–381 (1977)

    PubMed  CAS  Google Scholar 

  55. Gamacne, F. W. Jr., Gamacne, J. F.: Changes in axonal transport in neurones ofAsterias vulgaris andAsterias forbesei produced by colchicine and dimethyl sulfoxide. Cell Tissue Res.152, 423–436 (1974)

    Google Scholar 

  56. Gaskin, F., Kramer, S. B., Cantor, C. R., Adelstein, E., Shelanski, M. L.: A dynein-like protein associated with neurotubules. FEBS Lett.40, 281–286 (1974)

    PubMed  CAS  Google Scholar 

  57. Grafstein, B., McEwen, B. S., Shelanski, M. L.: Axonal transport of neurotubule protein. Nature (London)227, 289–290 (1970)

    CAS  Google Scholar 

  58. Grainger, F., Sloper, J. C.: Correlation between microtubular number and transport activity of the hypothalamo-neurohypophyseal secretory neurons. Cell Tissue Res.153, 101–114 (1974)

    PubMed  CAS  Google Scholar 

  59. Griffin, J. W., Price, D. L., Drachman, D. B., Engel, W. K.: Axonal transport to and from the motor nerve ending. Ann. N. Y. Acad. Sci.274, 31–45 (1976)

    PubMed  CAS  Google Scholar 

  60. Hammerschlag, R., Dravid, A. R., Ciu, A. Y.: Mechanism of axonal transport: a proposed role for calcium ions. Science188, 273–274 (1975)

    PubMed  CAS  Google Scholar 

  61. Hammond, G. R., Smith, R. S.: Inhibition of the rapid movements of optically detectable axonal particles by colchicine and vinblastine. Brain Res.128, 227–242 (1977)

    PubMed  CAS  Google Scholar 

  62. Hansson, H. A., Sjöstrand, J.: Ultrastructural effects of colchicine on the hypoglossal and dorsal vagal neurons of the rabbit. Brain Res.35, 379–396 (1971)

    PubMed  CAS  Google Scholar 

  63. Hendry, I. A., Stökel, K., Thoenen, H., Iversen, L. L.: The retrograde axonal transport of nerve growth factor. Brain Res.68, 103–121 (1974)

    PubMed  CAS  Google Scholar 

  64. Hindelang-Gertner, C., Stoeckel, M. è., Porte, A., Stutinsky, F.: Colchicine effects on neurosecretory neurons and other hypothalamic and hypophyseal cells, with special reference to change in the cytoplasmic membranes. Cell Tissue Res.170, 17–42 (1976)

    PubMed  CAS  Google Scholar 

  65. Hinckley, R. E. Jr.: Axonal microtubules and associated microfilaments stained by Alcian blue. J. Cell Sci.13, 753–762 (1973)

    Google Scholar 

  66. Hinckley, R. E., Burton, P. R.: Tannic acid staining of axonal microtubules. J. Cell Biol.63, 139 a (1974)

    Google Scholar 

  67. Hinckley, R. E. Jr., Green, L. S.: Effects of halothane and colchicine on microtubules and electrical activity of rabbit vagus nerves. J. Neurobiol.2, 97–106 (1971)

    Google Scholar 

  68. Hinckley, R. E., Samson, F. E.: Anesthetic-induced transformation of axonal microtubules. J. Cell Biol.53, 258–263 (1972)

    Google Scholar 

  69. Hinckley, R. E., Telser, A.: Halothane inhibition of neuroblastoma division and neurite formation. J. Cell Biol.55, 114 a (1972)

    Google Scholar 

  70. Hirano, A.: Neurofibrillary changes in conditions related to Alzheimer’s disease. In: Alzheimer’s Diseases and Related Conditions (eds.: G. E. W. Wolstenholme, M. O’Connor), pp. 185–201. Ciba Foundation Symposium. London: Churchill 1970

    Google Scholar 

  71. Hirano, A., Zimmerman, H. M.: Some new pathological findings in the central myelinated axon. J. Neuropath. Exp. Neurol.30, 325–336 (1971)

    PubMed  CAS  Google Scholar 

  72. Hoffman, P. N., Lasek, R. J.: The slow component of axonal transport. Identification of major structural polypeptides of the axon and their generality among mammalian neurons. J. Cell Biol.66, 351–366 (1975)

    PubMed  CAS  Google Scholar 

  73. Hökfelt, T., Dahlström, A.: Effects of two mitosis inhibitors (colchicine and vinblastine) on the distribution and axonal transport of noradrenaline storage particles, studied by fluorescence and electron microscopy. Z. Zellforsch.119, 460–482 (1971)

    PubMed  Google Scholar 

  74. Huneeus, F. C., Davison, P. F.: Fibrillar proteins from squid axons. I. Neurofilament protein. J. Mol. Biol.52, 415–428 ( 1970)

    PubMed  CAS  Google Scholar 

  75. James, K. A. C., Austin, L.: The binding in vitro of colchicine to axoplasmic proteins from chicken sciatic nerve. Biochem. J.117, 773–777 (1970)

    PubMed  CAS  Google Scholar 

  76. Järlfors, U., Smith, D. S.: Association between synaptic vesicles and neurotubules. Nature (London)224, 710–711 (1969)

    Google Scholar 

  77. Jeffrey, P. L., James, K. A. C., Kidman, A. D., Richards, A. M., Austin, L.: The flow of mitochondria in chicken sciatic nerve. J. Neurobiol.3, 199–208 (1972)

    PubMed  CAS  Google Scholar 

  78. Journey, L. J., Burdman, J., Whaley, A.: Electron microscopic study of spinal ganglia from vincristine-treated mice. J. Natl. Cancer Inst.43, 603–620 (1969)

    PubMed  CAS  Google Scholar 

  79. Karlsson, J. O., Sjöstrand, J.: The effects of colchicine on the axonal transport in the optic nerve and tract of the rabbit. Brain Res.13, 617–619 (1969)

    PubMed  CAS  Google Scholar 

  80. Karlsson, J. O., Sjöstrand, J.: Characterization of the fast and slow components of axonal transport in retinal ganglion cells. J. Neurobiol.2, 135–144 (1971)

    Google Scholar 

  81. Karlsson, J. O., Sjöstrand, J.: Transport of microtubular protein in axons of retinal ganglion cells. J. Neurochem.18, 975–982 (1971)

    PubMed  CAS  Google Scholar 

  82. Kennedy, R. D., Kink, B. R., Byers, M. R.: The effect of halothane on rapid axonal transport in the rabbit vagus. Anesthesiology36, 433–443 (1972)

    PubMed  CAS  Google Scholar 

  83. Khan, M. A., Ochs, S.: Slow axoplasmic transport of mitochondria (MAO) and lactic dehydrogenase in mammalian nerve fibers. Brain Res.96, 267–277 (1975)

    PubMed  CAS  Google Scholar 

  84. Kirkpatrick, J. B., Palmer, S. M.: Ionic requirements for rapid particulate axoplasmic flow. Am. J. Pathol.66, 4 a (1972)

    Google Scholar 

  85. Klatzo, I., Wisniewski, H., Streicher, E.: Experimental production of neurofibrillary degeneration. I. Light microscopic observations. J. Neuropathol. Exp. Neurol.24, 187–199 (1965)

    PubMed  CAS  Google Scholar 

  86. Kristensson, K.: Neural spread of herpes simplex virus. 7th Intern. Cong. Neuropathol.2, 329–332. Amsterdam: Excerpta Med. 1975

    Google Scholar 

  87. Kristensson, K., Lycke, E., Sjöstrand, J.: Transport of herpes simplex virus in peripheral nerves. Acta Physiol. Scand. (Suppl.)357, 14–14 (1970)

    Google Scholar 

  88. Kristensson, K., Lycke, E., Sjöstrand, J.: Retrograde transport of protein tracer in the rabbit hypoglossal nerve during regeneration. Brain Res.45, 175–181 (1972)

    PubMed  CAS  Google Scholar 

  89. Kuypers, H. G. J. M., Masiky, V. A.: Retrograde axonal transport of horseradish peroxidase from spinal cord to brain stem cell groups in the cat. Neurosci. Lett.1, 9–14 (1975)

    PubMed  CAS  Google Scholar 

  90. Lasek, R.: Protein transport in neurons. Intern. Rev. Neurobiol.13, 289–324 (1970)

    CAS  Google Scholar 

  91. Lasek, R. J., Hoffman, P. N.: The neuronal cytoskeleton, axonal transport and axonal growth. In: Cell Motility (eds.: R. Goldmann, T. Pollard, J. Rosenbaum), pp. 1021–1050. Cold Spring Harbor Lab. 1976

    Google Scholar 

  92. Lavail, J. H., Lavail, M. M.: The retrograde intraaxonal transport of horseradish peroxidasein the chick visual system: a light and electron microscopic study. J. Comp. Neurol.157, 303–358 (1974)

    PubMed  CAS  Google Scholar 

  93. Le Beux, Y. L.: An ultrastructural study of the synaptic densities, nematosomes, neurotubules, neurofilaments and of a further three-dimensional filamentous network as disclosed by the E-PTA staining procedure. Z. Zellforsch.143, 239–272 (1973)

    PubMed  Google Scholar 

  94. Leonetti, J., Seïte, R.: Influence du dibutyryl AMP cyclique et de la théophylline sur la fréquence des microtubules et des microfilaments nucléaires des neurones sympathiques. C. R. Acad. Sci. (Paris) D281, 423–426 (1975)

    CAS  Google Scholar 

  95. Lieberman, A. R.: Microtubule-associated smooth endoplasmic reticulum in the frog’s brain. Z. Zellforsch.116, 564–577 (1971)

    PubMed  CAS  Google Scholar 

  96. Lubinska, L.: Axoplasmic streaming in regenerating and in normal nerve fibers. Progr. Brain Res.13, 1–71(1964)

    CAS  Google Scholar 

  97. Lubinska, L.: Axoplasmic flow. In: Intern. Rev. Morphol. Vol. 17, pp. 241–296 (eds.: C. C. Pfeiffer J. R. Smythies). New York: Acad. Press 1975

    Google Scholar 

  98. Lubinska, L., Niermierko, S.: Velocity and intensity of bidirectional migration of acetylcholinesterase in transected nerves. Brain Res.27, 328–342 (1971)

    Google Scholar 

  99. McClure, W. O.: Effects of drugs on axoplasmic transport. Adv. Pharmacol. Chemother.

    Google Scholar 

  100. McGregor, A. M., Komiya, Y., Kidman, A. D., Austin L.: The blockage of axoplasmic flow of proteins by colchicine and cytochalasins A and B. J. Neurochem.21, 1059–1066(1973)

    PubMed  CAS  Google Scholar 

  101. Mayor, D., Tomlinson, D. R., Banks, P., Mraz, P.: Microtubules and the intra-axonal transport of noradrenaline storage (dense cored) vesicles. J. Anat.111, 344–343 (1972)

    PubMed  CAS  Google Scholar 

  102. Moran, D. T., Chapman, K. M., Ellis, R. A.: The fine structure of cockroach campaniform sensilla. J. Cell Biol.48, 155–173(1971)

    PubMed  CAS  Google Scholar 

  103. Moran, D. T., Varela, F. G.: Microtubules and sensory transduction. Proc. Natl. Acad. Sci. USA68, 757–760 (1971)

    PubMed  CAS  Google Scholar 

  104. Murray, M. R., Benitez, H. H.: Action of heavy water (D2O) on growth and development of isolated nervous tissues. In: Ciba Foundation Symposium Growth of the Nervous System (eds : E. W. Wolstenholme, M. O’Connor), pp. 148–178. London: Churchill 1968

    Google Scholar 

  105. Nadelhaft, I.: Microtubule densities and total numbers in selected axons of the crayfish abdominal nerve cord. J. Neurocytol.3, 73–86 (1974)

    PubMed  CAS  Google Scholar 

  106. Nagasava, J., Douglas, W. W., Schulz, R. A.: Ultrastructural evidence of secretion by exocytosis and of “synaptic vesicle” formation in posterior pituitary glands. Nature (London)227, 407–409 (1970)

    Google Scholar 

  107. Norström, A.: Axonal transport in the hypothalamoneurohypophyseal system (HNS) ot the rat 7th Intern. Cong. Neuropath.2, 315–324. Amsterdam: Excerpta Med. 1975

    Google Scholar 

  108. Norström, A., Hansson, H. A., Sjöstrand, J.: Effects of colchicine on axonal transport and ultrastructure of the hypothalamoneurohypophyseal system of the rat. Z. Zellforscn.113, 271–293 (1971)

    Google Scholar 

  109. Norström, A., Hansson, H. A.: Effects of colchicine on release of neurosecretory material from the posterior pituitary gland of the rat. Z. Zellforsch.142, 443–464 (1973)

    PubMed  Google Scholar 

  110. Norström, A., Sjöstrand, J.: Axonal transport of proteins in the hypothalamo-neurohypophyseal system of the rat. J. Neurochem.18, 29–40 (1971)

    PubMed  Google Scholar 

  111. Ochs, S.: The dependence of fast transport in mammalian nerve fibers on metabolism. Acta Neuropathol. Suppl.5, 86–96 (1971)

    Google Scholar 

  112. Ochs, S.: Characteristics and a model for fast axoplasmic transport in nerve. J. Neurobiol.2, 331–346 (1971)

    PubMed  CAS  Google Scholar 

  113. Ochs, S.: Energy metabolism and supply of ∼P to the fast axoplasmic transport mechanism in nerve. Fed. Proc.33, 1049–1058 (1974)

    CAS  Google Scholar 

  114. Ochs, S.: Axoplasmic transport. A basis for neural pathology. In: Penpheral Neuropathy (eds.: P. J. Dyck, P. K. Thomas, E. H. Lambert), pp. 213–230. Philadelphia-London-To-ronto: Saunders 1975

    Google Scholar 

  115. Ochs S., Hollingsworth, D.: Dependence of fast axoplasmic transport in nerve on oxidative metabolism. J. Neurochem.18, 107–114 (1971)

    PubMed  CAS  Google Scholar 

  116. Ochs, S., Ranish, N.: Characteristics of the fast transport system m mammalian nerve fibers.J. Neurobiol.2, 247–261 (1969)

    Google Scholar 

  117. Ochs, S., Smith, C.: Low temperature slowing and cold-block of fast axoplasmic transport in mammalian nerves in vitro. J. Neurobiol.6, 85–102 (1975)

    PubMed  CAS  Google Scholar 

  118. Ochs, S., Worth R.: Batrachotoxin block of fast axoplasmic transport in mammaliannerve fibers. Science187, 1087–1089 (1975)

    PubMed  CAS  Google Scholar 

  119. O’Connor, T. M., Houston, L. L., Samson, F.: Stability of neuronal microtubules to high pressure in vivo and in vitro. Proc. Natl. Acad. Sci. USA71, 4198–4202 (1974)

    PubMed  Google Scholar 

  120. Olsson, Y., Kristensson, K.: Retrograde axonal transport in peripheral nerves and signals for chromatolysis. 7th Intern. Cong. Neuropathol. Budapest: Akadémiai Kiadó 1974

    Google Scholar 

  121. Östergren, G.: Narcotized mitosis and the precipitation hypothesis of narcosis. Coll Int. C. N. R. S.26, 77–88 (1951)

    Google Scholar 

  122. Palay S. L.: Synapses in the central nervous system. J. Biophys. Biochem. Cytol.2,193–201 (1956)

    PubMed  CAS  Google Scholar 

  123. Partlow, L. M., Ross, C. D., Motwani, R., McDougal, D. B. Jr.: Transport of axonal enzymes in surviving segments of frog sciatic nerve. J. Gen. Physiol.60, 388–405 (1972)

    PubMed  CAS  Google Scholar 

  124. Paulson, J. C., McClure, W. O.: Inhibition of axoplasmic transport by mescaline and other trimethoxyphenylalkylamines. Mol. Pharmacol.9, 41–50 (1973)

    PubMed  CAS  Google Scholar 

  125. Paulson, J. C., McClure, W. O.: Microtubules and axoplasmic transport. Brain Res.73, 333–337 (1974)

    PubMed  CAS  Google Scholar 

  126. Paulson, J. C., McClure, W. O.: Microtubules and axoplasmic transport. Inhibition of transport by podophyllotoxin: an interaction with microtubule protein. J. Cell Biol.67, 461–468 (1975)

    PubMed  CAS  Google Scholar 

  127. Paulson, J. C., McClure, W. O.: Inhibition of axoplasmic transport by colchicine, podophyllotoxin, and vinblastine: an effect on microtubules. Ann. N. Y. Acad. Sci.253, 517–527 (1975)

    PubMed  CAS  Google Scholar 

  128. Peterson, E. R.: Neurofibrillar alterations in cord–ganglion cultures exposed to spindle inhibitors. J. Neuropathol. Exp. Neurol.28, 168 (1969)

    Google Scholar 

  129. Poisner, A. M., Bernstein, J.: A possible role of microtubules in catecholamine release from the adrenal medulla. Effect of colchicine,Vinca alkaloids and deuterium oxide. J. Pharmacol. Exp. Ther.177, 102– 108 (1971)

    PubMed  CAS  Google Scholar 

  130. Pomerat, C., Hendelman, W. J., Raiborn, C. W., Massey, J. F.: Dynamic activities of nervous tissue in vitro. In: The Neuron (ed.: H. Hyden), pp. 119– 178. New York: Acad. Press 1967

    Google Scholar 

  131. Potter, H. D.: The distribution of neurofibrils coextensive with microtubules and neurofilaments in dendrites and axons of the tectum, cerebellum and pallidum of the frog. J. Comp. Neurol.143, 385–410 (1971)

    PubMed  CAS  Google Scholar 

  132. Price, M. T.: The effects of colchicine and lumicolchicine on the rapid phase of axonal transport in the rabbit visual system. Brain Res.77, 497–501 (1974)

    PubMed  CAS  Google Scholar 

  133. Price, D. L., Griffin, J., Young, A., Peck, K., Stocks, A.: Tetanus toxin: direct evidence for retrograde intraaxonal transport. Science188, 945–947 (1975)

    PubMed  CAS  Google Scholar 

  134. Price, D. L., Griffin, J. W.: Structural substrate of protein synthesis and transport in spinal motor neurons. In: Amyotrophic Lateral Sclerosis (eds.: J. M. Andrews, R. T. Johnson, M. A. B. Brazier), pp. 1–32. New York-San Francisco-London: Acad. Press 1976

    Google Scholar 

  135. Pumplin, D. W., McClure, W. O.: Effects of cytochalasin B and vinblastine on the release of acetylcholine from a sympathetic ganglion. Eur. J. Pharmacol.28, 316–325 (1974)

    PubMed  CAS  Google Scholar 

  136. Reese, T. S.: Olfactory cilia in the frog. J. Cell Biol.25, 209–230 (1965)

    PubMed  CAS  Google Scholar 

  137. Reid, J. L., Kopin, I. J.: The effects of ganglionic blockage, reserpine and vinblastine on plasma catecholamines and dopamine-β-hydroxylase in the rat. J. Pharmacol. Exp. Ther.193, 748–756 (1968)

    Google Scholar 

  138. Rodriguez Echandia, E. L., Piezzi, R. S.: Microtubules in the nerve fibers of the toadBufo arenarum Hensel. Effect of low temperature on the sciatic nerve. J. Cell Biol.39, 491–497 (1968)

    Google Scholar 

  139. Roisen, F. J., Braden, W. G., Friedman, J.: Neurite development in vitro. III. The effects of several derivatives of cyclic AMP, colchicine and colcemid. Ann. N. Y. Acad. Sci.253, 545–561 (1975)

    PubMed  CAS  Google Scholar 

  140. Roisen, F. J., Murphy, R. A.: Neurite development in vitro. II. The role of microfilaments and microtubules in dibutyryl adenosine 3′,5′-cyclic monophosphate and nerve growth factor stimulated maturation. J. Neurobiol.4, 397–412 (1973)

    PubMed  CAS  Google Scholar 

  141. Roth, L. E., Pihlaja, D. J., Shigenaka, Y.: Microtubules in the heliozoan axopodium. I. The gradion hypothesis of allosterism in structural proteins. J. Ultrastruct. Res.30, 7–37 (1970)

    PubMed  CAS  Google Scholar 

  142. Samson, F. E. Jr., Hinckley, R. E. Jr.: Neuronal microtubular systems. Anesthesiology36, 417–421 (1972)

    PubMed  Google Scholar 

  143. Saubermann, A. J., Gallagher, M. L.: Allison and Nunn revisited. Anesthesiology39, 357 (1973)

    Google Scholar 

  144. Saubermann, A. J., Gallagher, M. L.: Mechanisms of general anesthesia: failure of pentobarbital and halothane to depolymerize microtubules in mouse optic nerve. Anesthesiology38, 25–29 (1973)

    PubMed  CAS  Google Scholar 

  145. Schmitt, F. O.: Fibrous proteins—neuronal organelles. Proc. Natl. Acad. Sci. USA60, 1092–1101(1968)

    PubMed  CAS  Google Scholar 

  146. Seïte, R., Escaig, J., Couineau, S.: Microfilaments et microtubules nucléaires et organisation ultrastructurale des bâtonnets intranucléaires des neurones sympathiques. J. Ultrastruct. Res.37, 449–478 (1971)

    PubMed  Google Scholar 

  147. Seite, R., Mei, N., Vuillet-Luciani, J.: Effect of electrical stimulation on nuclear microfilaments and microtubules of sympathetic neurons submitted to cycloheximide. Brain Res.50, 419–423 (1973)

    PubMed  CAS  Google Scholar 

  148. Sjöstrand, J., Frizell, M., Hasselgren, P. O.: Effects of colchicine on axonal transport in peripheral nerves. J. Neurochem.17, 1563–1570 (1970)

    PubMed  Google Scholar 

  149. Sloper, J. C., Grainger, F.: Quantitation of microtubules in secretory neurons. In: Microtubules and Microtubule Inhibitors (eds.: M. Borgers, M. De Brabander), pp. 281–287. Amsterdam-Oxford: North Holland 1975

    Google Scholar 

  150. Smith, B. H.: Neuroplasmic transport in the nervous system of the cockroachPeriplaneta americana. J. Neurobiol.2, 107–118 (1971)

    PubMed  CAS  Google Scholar 

  151. Smith, D. E.: The location of neurofilaments and microtubules during the postnatal development of Clarke’s nucleus in the kitten. Brain Res.55, 41–54 (1973)

    PubMed  CAS  Google Scholar 

  152. Smith, D. S., Järlfors, U., Beraneck, R.: The organization of synaptic axoplasm in the lamprey (Petromyzon marinus) central nervous system. J. Cell Biol.46, 199–219 (1970)

    PubMed  CAS  Google Scholar 

  153. Smith, D. S., Järlfors, U., Cameron, B. F.: Morphological evidence for the participation of microtubules in axonal transport. Ann. N. Y. Acad. Sci.253, 472–506 (1975)

    PubMed  CAS  Google Scholar 

  154. Sorimachi, M., Oesch, F., Thoenen, H.: Effects of colchicine and cytochalasin B on the release of3H-norepinephrine from guinea-pig atria evoked by high potassium, nicotine and tyramine. Arch. Pharmacol.276, 1–12 (1973)

    CAS  Google Scholar 

  155. Stöckel, K., Paravicini, U., Thoenen, H.: Specificity of the retrograde axonal transport of nerve growth factor. Brain Res.76, 413–421 (1974)

    PubMed  Google Scholar 

  156. Terry, R. D. Peña, C.: Experimental production of neurofibrillary degeneration. II. Electron mictroscopy, phosphatase histochemistry and electron probe analysis. J. Neuropath. Exp. Neurol.24, 200–210 (1965)

    PubMed  CAS  Google Scholar 

  157. Thurm, U.: An insect mechanoreceptor. I. Fine structure and adequate stimulus. Cold Spring Harbor Symp. Quant. Biol.30, 75–82 (1965)

    CAS  Google Scholar 

  158. Trifaro, J. M., Collier, B., Lastoweka, A., Stern, D.: Inhibition by colchicine and by vinblastine of acetylcholine-induced catecholamine release from the adrenal gland: an anti-cholinergic action, not an effect on microtubules. Molec. Pharmacol.8, 264–267 (1972)

    CAS  Google Scholar 

  159. Weiss, P. A.: Neuronal dynamics. Neurosci. Res. Program Bull.5, 371–400 (1967). Reprinted in: Dynamics of Development. Experiments and Interferences (ed.: P. A. Weiss). New York-London: Acad. Press 1968

    Google Scholar 

  160. Weiss, P. A.: Neuronal dynamics and neuroplasmic (“axonal”) flow. In: Cellular Dynamics of the Neuron (ed.: S. H. Barondes), pp. 3–34. New York-London: Acad. Press 1969

    Google Scholar 

  161. Weiss, P. A., Hiscoe, H. B.: Experiments on the mechanism of nerve growth. J. Exp. Zool.107, 315–395 (1948)

    PubMed  CAS  Google Scholar 

  162. Weiss, P. A., Mayr, R.: Neuronal organelles in neuroplasmic (“axonal”) flow. I. Mitochondria. II. Neurotubules. Acta Neuropath. Suppl.5, 187–197; 198–206 (1971)

    Google Scholar 

  163. Weiss, P., Taylor, A. C.: Impairment of growth and myelinization in regenerating nerve fibers subject to constriction. Proc. Soc. Exp. Biol. Med.55, 77–80 (1944)

    Google Scholar 

  164. Weiderhold, M. L.: Mechanosensory transfunction in “sensory” and “motile” cilia. Ann. Rev. Biophys. Bioengin.5, 39–62 (1976)

    Google Scholar 

  165. Willard, M., Cowan, W. M., Vazeles, P. R.: The polypeptide composition of intraaxonally transported proteins: evidence for four transport velocities. Proc. Natl. Acad. Sci. USA71, 2183–2187 (1974)

    PubMed  CAS  Google Scholar 

  166. Wisniewski, H., Shelanski, M. L., Terry, R. D.: Experimental colchicine encephalopathy. I. Induction of neurofibrillary degeneration. Lab. Invest.17, 577–587 (1967)

    PubMed  CAS  Google Scholar 

  167. Wisniewski, H., Terry, R. D., Shelanski, M. L.: Neurofibrillary degeneration of nerve cells after subarachnoid injection of mitotic spindle inhibitors. J. Neuropathol. Exp. Neurol.28, 168–169 (1969)

    Google Scholar 

  168. Wisniewski, H., Shelanski, M. L., Terry, R. D.: Effects of mitotic spindle inhibitors on neurotubules and neurofilaments in anterior horn cells. J. Cell Biol.38, 224–229 (1968)

    PubMed  CAS  Google Scholar 

  169. Wolff, J. R., Wolff, A.: Is an ATP-ase the drive of the axonal flow? 7th Intern. Cong. Neuropathol.2, 305–308. Amsterdam: Excerpta Medica 1975

    Google Scholar 

  170. Wooten, G. F., Kopin, I. J., Axelrod, J.: Effects of colchicine and vinblastine on axonal transport and transmitter release in sympathetic nerves. Ann. N. Y. Acad. Sci.253, 528–534 (1975)

    PubMed  CAS  Google Scholar 

  171. Wuerker, R. B.: Neurofilaments and glial filaments. Tissue Cell2, 1–9 (1970)

    PubMed  CAS  Google Scholar 

  172. Yamada, K. M., Wessells, N. K.: Axon elongation. Effect of nerve growth factor on microtubule protein. Exptl. Cell Res.66, 346–352 (1971)

    PubMed  CAS  Google Scholar 

  173. Zelená, J.: Bidirectional movements of mitochondria along axons of an isolated nerve segment. Z. Zellforsch.92, 186–196 (1968)

    PubMed  Google Scholar 

  174. Zelená, J., Lubińska, L., Gutman, E.: Accumulation of organelles at the ends of interrupted axons. Z. Zellforsch.91, 200–219 (1968)

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratoires d’Anatomie Pathologique et de Microscopie Electronique, Université Libre de Bruxelles, rue aux Laines 97, Bruxelles, B-1000, Belgium

    Prof. Dr. Pierre Dustin

Authors
  1. Prof. Dr. Pierre Dustin
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 1978 Springer-Verlag Berlin · Heidelberg

About this chapter

Cite this chapter

Dustin, P. (1978). Neurotubules: Neuroplasmic Transport, Neurosecretion, Sensory Cells. In: Microtubules. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-96436-7_11

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-96436-7_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-96438-1

  • Online ISBN: 978-3-642-96436-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation