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Hormone Treatment of Cancer of the Prostate

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New Trends in the Treatment of Cancer

Abstract

The hormone treatment of prostatic cancer is based on the dependence of prostatic cells on the stimulus of androgens for their development and maintenance. The prostate gland remains small in eunuchoid individuals throughout puberty and shrinks after castration or the suppression of androgens, direct or indirect, by administration of estrogens (Huggins and Clarke, 1940). The extension of this study to the treatment of prostatic cancer as described by Huggins and Hodges (1941) showed that castration or estrogen therapy produced a dramatic response in about 80% of patients with disseminated prostatic cancer. If prostatic cancer is not amenable to cure by radical prostatectomy (stage A or B in Whitmore’s classification, 1963), hormone therapy should be instituted. Barnes (1959) has shown that delay in instituting anti-androgen therapy after prostatic cancer has been diagnosed results in a shorter average survival than if it had been begun immediately.

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Authors and Affiliations

  1. Division of Urology, University of Oregon Medical School, Portland, Oregon, USA

    Dr. Clarence V. Hodges & Dr. Dieter Kirchheim

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  1. Dr. Clarence V. Hodges
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  2. Dr. Dieter Kirchheim
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Editors and Affiliations

  1. 13, Cours des Bastion, CH 1200, Genève, Switzerland

    L. Manuila M.D., F.M.H. Derm. , S. Moles M.B., B.Ch., B.A.O., D.R.C.O.G.  & P. Rentchnick M.D.P.D., F.M.H. Med. int. ,  & 

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Hodges, C.V., Kirchheim, D. (1967). Hormone Treatment of Cancer of the Prostate. In: Manuila, L., Moles, S., Rentchnick, P. (eds) New Trends in the Treatment of Cancer. Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer, vol 8. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-87620-2_7

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  • DOI: https://doi.org/10.1007/978-3-642-87620-2_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-87622-6

  • Online ISBN: 978-3-642-87620-2

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