Abstract
The discussions presented in Part 2 revealed the true character of natural selection. It is not so much an advocator or mediator of heritable changes, but rather it is an extremely efficient policeman which conserves the vital base sequence of each gene contained in the genome. As long as one vital function is assigned to a single gene locus within the genome, natural selection effectively forbids the perpetuation of mutations affecting the active sites of a molecule. In the case of the enzyme locus, tolerable mutations might change the kinetic property such as pH optimum and Michaelis constant of the enzyme, but never the basic character. Therefore, the dihydro-orotase locus would forever remain the dihydro-orotase locus, and the β-galactosidase locus would remain the β-galactosidase locus.
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Ohno, S. (1970). Duplication for the Sake of Producing More of the Same. In: Evolution by Gene Duplication. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-86659-3_11
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DOI: https://doi.org/10.1007/978-3-642-86659-3_11
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