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Animal Models Relating Behavioral Stress and Cardiovascular Pathology

  • Chapter
Coronary-Prone Behavior

Abstract

At the present time there appear to be many clues, but no convincing direct evidence, specifying the exact intervening pathophysiological mechanisms that link coronary risk factors to cardiovascular disease. This is particularly true of the physiological and biochemical mechanisms that may link behavioral variables to the etiology and pathogenesis of atherosclerosis and coronary heart disease. In the face of this intransigent problem, behavioral experiments in animals offer an opportunity to study the biological mechanisms linking specific patterns of behavior with various manifestations of cardiovascular pathology.

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References

  1. Cohen, D.H., Durkovic, R.G.: Cardiac and respiratory conditioning, differentiation, and extinction in the pigeon. J. Exp Anal Behav 9:681–688, 1966.

    Article  PubMed  Google Scholar 

  2. Dykman, R.A., Gantt, W.H., Whitehorn, J.C.: Conditioning as emotional sensitization and differentiation. Psychol Monographs 79:1–17, 1956.

    Article  Google Scholar 

  3. Obrist, P.A., Webb, R.A.: Heart rate during conditioning in dogs: relationship to somatic-motor activity. Psychophysiology 4:7–34, 1967.

    Article  PubMed  Google Scholar 

  4. Schneiderman, N., VanDercar, D.H., Yehle, A.L., Manning, A.A., Golden, T., Schneiderman, E.: Vagal compensatory adjustment: relationship to heart-rate classical conditioning in rabbits. J Comp Physiol Psychol 68:176–183, 1969.

    Google Scholar 

  5. Randall, D.C., Brady, J.V., Martin, K.H.: Cardiovascular dynamics during classical appetitive and aversive conditioning in laboratory primates. Pavlov J Biol Sc 10:66–75, 1975.

    Google Scholar 

  6. Bolme, P., Novotny, J.: Conditional reflex activation of the sympathetic cholinergic vasodilator nerves in the dog. Acta Physiol Scand 77:58–67, 1969.

    Article  PubMed  Google Scholar 

  7. Brickman, A., Schneiderman, N.: Classical conditioning of cardiovascular changes in rabbits using stimulation of posterior hypothalamus as the US. Psychophysiology 14:287–292, 1977.

    Article  PubMed  Google Scholar 

  8. VanDercar, D.H., Elster, A.S., Schneiderman, N.: Heart rate classical conditioning in rabbits to hypothalamic or septal US stimulation. J Comp Physiol Psychol 72:145–152, 1970

    Article  PubMed  Google Scholar 

  9. Cohen, D.H., Obrist, P.A.: Interactions between behavior and the cardiovascular system. Circ Res 31: 693–706, 1975.

    Google Scholar 

  10. Fredericks, A., Moore, J.W., Metcalf, F.U., Schwaber, J.S., Schneiderman, N.: Selective autonomic blockade of conditioned and unconditioned heart rate changes in rabbits. Pharmacol Biochem Behav 493–501, 1974.

    Google Scholar 

  11. Ellison, G.D., Zanchetti, A.: Sympathetic cholinergic vasodilation in muscles. Specific appearance during conditioned movement. Nature (London) 232:124–125, 1971.

    Article  Google Scholar 

  12. Martin, J., Sutherland, C.J., Zbrozyna, A.W.: Habituation and conditioning of the defense reactions and their cardiovascular components in cats and dogs. Pfluegers Arch 365:37–47, 1976.

    Article  Google Scholar 

  13. Adams, D.B., Baccelli, G., Mancia, G., Zanchetti, A.: Cardiovascular changes during naturally elicited fighting behavior in the cat. Am J Physiol 216:1226–1235, 1968.

    Google Scholar 

  14. Gavin, W.P., Silbret, M., Gaide, M.S., Klose, K.J., Schneiderman, N., Smith, J., Augenstern, J.S.: Heart rate and blood pressure changes during signal avoidance and aversive classical conditioning in rhesus monkeys. Submitted for publication.

    Google Scholar 

  15. Dews, P.B., Herd, J.A.: Behavioral activities and cardiovascular functions: effects of hexamethonium on cardiovascular changes during strong sustained static work in rhesus monkeys. J Pharmacol Exp Ther 189:12–23, 1974.

    PubMed  Google Scholar 

  16. Klose, K.J., Augenstein, J.S., Schneiderman, N., Manas, K., Abrams, B., Bloom, L.J.: Selective autonomic blockade of conditioned and unconditioned cardiovascular changes in rhesus monkeys. J Comp Physiol Psychol 89: 810–818, 1975.

    Article  PubMed  Google Scholar 

  17. Ramsay, D. A.: Form and characteristics of the cardiovascular conditioned response in rhesus monkeys. Conditional Reflex 5:36–51, 1970.

    PubMed  Google Scholar 

  18. Miminoshvili, D.I., Magakian, G.O., Kokaia, G.I.: Attempts to obtain a model of hypertension and coronary insufficiency in monkeys. In Theoretical and Practical Problems of Medicine and Biology in Experiments on Monkeys (Utikin, I.A., ed.). New York: Pergamon, 1960.

    Google Scholar 

  19. Mason, J.W., Mangan, G.F., Brady, J.V., Conrad, D., Rioch, D.M.: Concurrent plasma epinephrine, norepinephrine, and 17-hydroxycorticosteroid levels during conditioned emotional disturbances in monkeys. Psychosom Med 23:344–353, 1961.

    PubMed  Google Scholar 

  20. Lawler, J.E., Obrist, P.A., Lawler, K.A.: Cardiovascular function during pre-avoidance, avoidance, and post-avoidance in dogs. Psychophysiology 12: 4–11, 1975.

    Article  PubMed  Google Scholar 

  21. Mason, J.W., Brady, J.V., Toison, W.W.: Behavioral adaptations and endocrine activity. In Endocrines and the Central Nervous System (Levine, R., ed.). Baltimore: Williams & Williams, 1966.

    Google Scholar 

  22. Lawler, J.E., Botticelli, L.J., Lown, B.: Changes in cardiac refractory period during signalled avoidance in dogs. Psychophysiology 13:373–377, 1976.

    Article  PubMed  Google Scholar 

  23. Han, J., Moe, G.K.: Nonuniform recovery of excitability in ventricular muscle. Circ Res 14:44–60, 1964.

    PubMed  Google Scholar 

  24. Cranefield, P.F., Wit, A.L., Hoffman, B.F.: Genesis of cardiac arrhythmias. Circulation 47:190–204, 1973.

    PubMed  Google Scholar 

  25. Herd, J.A., Morse, W.H., Kelleher, R.J., Jones, L.G.: Arterial hypertension in the squirrel monkey during behavioral experiments. Am J Physiol 217:24–29, 1969.

    PubMed  Google Scholar 

  26. Benson, H., Herd, J.A., Morse, W.H., Kelleher, R.J.: Behavioral induction of arterial hypertension and its reversal. Am J Physiol 217:30–34, 1969.

    PubMed  Google Scholar 

  27. Harris, A.H., Gilliam, W., Findley, J.D., Brady, J.V.: Instrumental conditioning of large-magnitude daily 12-hour blood pressure elevations in the baboon. Science 182:175–177, 1973.

    Article  PubMed  Google Scholar 

  28. Anderson, D.E., Tosheff, J.: Cardiac output and total peripheral resistance changes during preavoidance periods in the dog. J Appl Physiol 34:650–654, 1973.

    PubMed  Google Scholar 

  29. Forsyth, R.P.: Regional blood flow changes during 72-hour avoidance schedules in the monkey. Science 173:546–548, 1971.

    Article  PubMed  Google Scholar 

  30. Mason, J.W., Toison, W.W., Brady, J.V., Tolliver, G.A., Gilmore, L.I.: Urinary epinephrine and norepinephrine responses to 72-hour avoidance sessions in the monkey. Psychosom Med 30:654–665, 1968.

    PubMed  Google Scholar 

  31. Forsyth, R.P.: Blood pressure responses to long-term avoidance schedules in the restrained rhesus monkey. Psychosom Med 31:300–309, 1969.

    PubMed  Google Scholar 

  32. Corley, K.C., Shiel, F.O’M., Mauck, H.P., Greenhoot, J.: Electrocardiographic and cardiac morphological changes associated with environmental stress in squirrel monkeys. Psychosom Med 35:361–364, 1973.

    PubMed  Google Scholar 

  33. Corley, K.C., Mauck, H.P., Shiel, F.O’M.: Cardiac-responses associated with “yoked-chair” shock avoidance in squirrel monkeys. Psychophysiology 12:439–444, 1975.

    Article  PubMed  Google Scholar 

  34. Brady, J.V., Porter, R., Conrad, D., Mason, J.: Avoidance behavior and the development of gastroduodenal ulcers. J Exp Anal Behav 1:69–72, 1958.

    Article  PubMed  Google Scholar 

  35. Moss, A.J., Schenk, E.A.: Cardiovascular effects of sustained norepinephrine infusions in dogs. Circ Res 27:1013–1022, 1970.

    PubMed  Google Scholar 

  36. Melville, K.I., Garvey, H.L., Shister, H.E., Knaack, J.: Central nervous system stimulation and cardiac ischemic changes in monkeys. Ann NY Acad Sci 156:241–260, 1969.

    Article  PubMed  Google Scholar 

  37. Bunag, R.D., Riley, E., Montello, M.: Sustained pressor responsiveness to prolonged hypothalamic stimulation in awake rats. Am J Physiol 231:1708–1715, 1976.

    PubMed  Google Scholar 

  38. Folkow, B., Rubenstein, E.H.: Cardiovascular effects of acute and chronic stimulation of the hypothalamic defence area in the rat. Acta Physiol Scand 68:48–57, 1966.

    Article  Google Scholar 

  39. Weiss, J.M.: Effects of coping behavior on development of gastroduodenal lesions in rats. Proc. 75th Ann. Convention, APA 263–264, 1968.

    Google Scholar 

  40. Richter, C.P.: On phenomenon of sudden death in animals and man. Psychosom Med 19:191–198, 1957.

    PubMed  Google Scholar 

  41. Schneider, R.A.: Patterns of autonomic response to startle in subjects with and without coronary artery disease. (Abstract). Clin Res 15:59, 1957.

    Google Scholar 

  42. Manning, J.W., Cotten, M.deV.: Mechanism of cardiac arrhythmias induced by diencephalic stimulation. Am J Physiol 203:1120–1123, 1962.

    Google Scholar 

  43. Ebert, P.A., Allgood, R.J., Sabiston, D.C.: Effect of cardiac denervation on arrhythmia following coronary artery occlusion. Surg Forum 18:114–121, 1967.

    Google Scholar 

  44. Friedman, R., Dahl, L.: The effect of chronic conflict on the blood pressure of rats with a genetic susceptibility to experimental hypertension. Psychosom Med 37:402–416, 1975.

    PubMed  Google Scholar 

  45. Dahl, L.K., Heine, M., Tassinari, L.J.: Effects of chronic excess salt ingestion. Evidence that genetic factors play an important role in susceptibility to experimental hypertension. J Exper Med 115:1173–1190, 1962.

    Article  Google Scholar 

  46. Dahl, L.K., Heine, M., Tassinari, L.J.: Effects of chronic excess salt ingestion. Vascular reactivity in two strains of rats with opposite genetic susceptibility to experimental hypertension. Circulation 29, 30 (Suppl. II): 11–22, 1964.

    Google Scholar 

  47. Overmier, J.B., Seligman, M.E.P.: Effects of inescapable shock upon subsequent escape and avoidance learning. J Comp Physiol Psychol 63:23–33, 1967.

    Article  Google Scholar 

  48. Seligman, M.E.P., Maier, S.F.: Failure to escape traumatic shock. J Exp Psychol 74:1–9, 1967.

    Article  PubMed  Google Scholar 

  49. Weiss, J.M., Glazer, H.I.: Effects of acute exposure to stressors on subsequent avoidance-escape behavior. Psychosom Med 37:499–521, 1975.

    PubMed  Google Scholar 

  50. Weiss, J.M., Glazer, H.I., Pohorecky, L.A., Brick, J., Miller, N.E.: Effects of chronic exposure to stressors on avoidance-escape behavior and on brain norepinephrine. Psychosom Med 37:522–534, 1975.

    PubMed  Google Scholar 

  51. Sokolov, E.N.: Perception and the Conditioned Reflex. New York: Macmillan, 1963.

    Google Scholar 

  52. Irving, L.: Respiration in diving mammals. Physiol Rev 19:112–133, 1939.

    Google Scholar 

  53. Schneider, E.C.: Observations on holding the breath. Am J Physiol 94:464–470, 1930.

    Google Scholar 

  54. Herd, J.A.: Overall regulation of the circulation. Annu Rev Physiol 32:289–312, 1970.

    Article  PubMed  Google Scholar 

  55. Feigl, E., Folkow, B.: Cardiovascular responses in “diving” and during brain stimulation in ducks. Acta Physiol Scand 57:99–110, 1963.

    Article  PubMed  Google Scholar 

  56. Wolf, S.: Sudden death and the oxygen-conserving reflex. Am Heart J 71:840–849, 1966.

    Article  PubMed  Google Scholar 

  57. Seligman, M.E.P.: Helplessness: On Depression, Development, and Death. San Francisco: W.H. Freeman, 1975.

    Google Scholar 

  58. Weiss, J.M., Stone, E.A., Harrell, N.: Coping behavior and brain norepinephrine level in rats. J Comp Physiol Psychol 72:153–160, 1970.

    Article  PubMed  Google Scholar 

  59. Glazer, H.I., Weiss, J.M., Pohorecky, L.A., Miller, N.E.: Monoamines as mediators of avoidance-escape behavior. Psychosom Med 37:535–543, 1975.

    PubMed  Google Scholar 

  60. Obrist, P.A., Howard, J.L., Lawler, J.E., Galosy, R.A., Meyers, K.A., Gaebelein, C.J.: The cardiac somatic interaction. In Cardiovascular Psychophysiology (Obrist, P.A., Black, A.H., Brener, J., DiCara, L.V., eds.). Chicago: Aldine, 1974.

    Google Scholar 

  61. Powell, D.A., Goldberg, S.R., Dauth, G.W., Schneiderman, E., Schneiderman, N.: Adrenergic and cholinergic blockade of cardiovascular responses to subcortical electrical stimulation in unanesthetized rabbits. Physiol Behav 8:927–936, 1972.

    Article  PubMed  Google Scholar 

  62. Henry, J.P., Meehan, J.P., Stephens, P.M.: The use of psychosocial stimuli to induce prolonged systolic hypertension in mice. Psychosom Med 29: 408–432, 1967.

    PubMed  Google Scholar 

  63. Henry, J.P., Stephens, P.M., Axelrod, J., Mueller, R.A.: Effect of psychosocial stimulation on the enzymes involved in the biosynthesis and metabolism of noradrenaline and adrenaline. Psychosom Med 33: 227–237, 1971.

    PubMed  Google Scholar 

  64. Henry, J.P., Ely, D.L., Stephens, P.M., Ratcliffe, H.L., Santisteban, G.A., Shapiro, A.P.: The role of psychosocial factors in the development of arteriosclerosis in CBA mice: observations on the heart, kidney and aorta. Atherosclerosis 14:203–218, 1971.

    Article  PubMed  Google Scholar 

  65. Henry, J.P., Ely, D.L., Stephens, P.M.: Changes in catecholamine-controlling enzymes in response to psychosocial activation of defence and alarm reactions. In Physiology, Emotion and Psychosomatic Illness. Amsterdam: CIBA Foundation, 1972.

    Google Scholar 

  66. Von Holst, D.: Sozialer stress bei Tupujas (Tupaia belangen) Die Aktivierung des sympathischen Nervensystems und ihre Beziehung zu hormonal ausgelosten, ethologischen und physiologischen Veranderungen. Z Verg Physiol 63:1–58, 1969.

    Article  Google Scholar 

  67. Von Holst, D.: Renal failure as the cause of death in Tupaia belangen (tree shrews) exposed to persistent social stress. J Comp Physiol 78: 236–273, 1972.

    Article  Google Scholar 

  68. Lapin, B., Cherkovitch, G.M.: Environmental change causing the development of neuroses and corticovisceral pathology in monkeys. In Society, Stress and Disease: The Psychosocial Environment and Psychosomatic Diseases (Levi, L., ed.). London: Oxford University Press, 1971.

    Google Scholar 

  69. Miminoshvili, D.I.: Experimental neuroses in monkeys. In Theoretical and Practical Problems in Experiments on Monkeys (Uttan, I., ed.). Oxford, 1956.

    Google Scholar 

  70. Berne, R.M., Levy, M.N.: Cardiovascular Physiology, 2nd ed. St. Louis: Mosby, 1972.

    Google Scholar 

  71. Cohen, D.H., MacDonald, R.L.: A selective review of central neural pathways involved in cardiovascular control. In Cardiovascular Psychophysiology (Obrist, P.A., Black, A.H., Brener, J., DiCara, L.V., eds.). Chicago: Aldine, 1974. pp. 33–59.

    Google Scholar 

  72. Schneiderman, N., Francis, J.S., Sampson, L.D., Schwaber, J. S.: CNS integration of learned cardiovascular behavior. In The Autonomic Nervous System: Advances in Research (DiCara, L.V., ed.). New York: Plenum, 1974, pp. 277–309.

    Chapter  Google Scholar 

  73. Green, J.H.: Physiology of baroreceptor function: mechanism of receptor stimulation. In Baroreceptors and Hypertension (Kezdi, P., ed.). Oxford: Pergamon, 1967.

    Google Scholar 

  74. Getz, B., Sirnes, T.: The localization within the dorsal motor nucleus. J Comp Neurol 90:95–110, 1949.

    Article  PubMed  Google Scholar 

  75. Cohen, D.H., Schnall, A.M., MacDonald, R.L., Pitts, L.H.: Medullary cells of origin of vagal cardioinhibitory fibers in the pigeon. I. Anatomical studies of peripheral vagus nerve and the dorsal motor nucleus. J Comp Neurol 140:299–320, 1970.

    Article  PubMed  Google Scholar 

  76. Mitchell, G., Warwick, R.: The dorsal vagal nucleus. Acta Anat 25:376–395, 1955.

    Article  Google Scholar 

  77. Kerr, F.W.L.: Preserved vagal visceromotor function following destruction of the dorsal motor nucleus. J Physiol 202:755–769, 1969.

    PubMed  Google Scholar 

  78. Thomas, M.R., Calaresu, F.R.: Localization and function of medullary sites mediating vagal bradycardia in the cat. Am J Physiol 226:1344–1349, 1974.

    PubMed  Google Scholar 

  79. Schwaber, J., Schneiderman, N.: Aortic nerve activated cardioinhibitory neurons and inter-neurons. Am J Physiol 229:783–789, 1975.

    PubMed  Google Scholar 

  80. McAllen, R.M., Spyer, K.M.: The location of cardiac vagal preganglionic motor-neurones in the medulla of the cat. J Physiol 258:187–204, 1976.

    PubMed  Google Scholar 

  81. Kaufman, M.P., Hamilton, R.B., Petrik, G.K., Schneiderman, N.: Role of subthalamus in mediation of bradycardia responses in rabbits. Neurosci Abstr 3:22, 1977.

    Google Scholar 

  82. Hilton, S.M., Spyer, K.M.: Participation of the anterior hypothalamus in the baroreceptor reflex. J Physiol 218:271–293, 1971.

    PubMed  Google Scholar 

  83. Gimpl, M.P., Brickman, A.L., Kaufman, M.P., Schneiderman, N.: Temporal relationships during barosensory attenuation in the conscious rabbit. Am J Physiol 230:1480–1486, 1976.

    PubMed  Google Scholar 

  84. Spyer, K.M.: Baroreceptor sensitive neurons in the anterior hypothalamus of the cat. J Physiol 224:245–257, 1972.

    PubMed  Google Scholar 

  85. Brickman, A.L., Kaufman, M.P., Petrik, G.K., Schneiderman, N.: Responses of anterior hypothalamic neurons to stimulation of aortic nerve and caudate nucleus in rabbits. Exp Neurol 56:622–627, 1977.

    Article  PubMed  Google Scholar 

  86. Klevans, L.R., Gebber, G.L.: Facilitory forebrain influence on cardiac component of baroreceptor reflexes. Am J Physiol 219:1235–1241, 1970.

    PubMed  Google Scholar 

  87. Magoun, H.W.: Excitability of the hypothalamus after degeneration of corticofugal connections from the frontal lobe. Am J Physiol 112:530–532, 1938.

    Google Scholar 

  88. Calaresu, F.R., Ciriello, J., Mogenson, G.J.: Identification of pathways mediating cardiovascular responses elicited by stimulation of the septum in the rat. J Physiol 260:515–530, 1976.

    PubMed  Google Scholar 

  89. Faiers, A.A., Calaresu, F.R., Mogenson, G.J.: Pathway mediating hypotension elicited by stimulation of the amygdala in the rat. Am J Physiol 228:1358–1366, 1975.

    PubMed  Google Scholar 

  90. Lindgren, P., Rosen, A., Strandberg, P., Uvnas, P.: The sympathetic vasodilator and vasoconstrictor outflow—a corticospinal autonomic pathway. J Comp Neurol 105:95–104, 1956.

    Article  PubMed  Google Scholar 

  91. Hilton, S.M.: Hypothalamic regulation of the cardiovascular system. Br Med Bull 22:243–248, 1966.

    PubMed  Google Scholar 

  92. Hilton, S.M., Zbrozyna, A.W.: Amygdaloid region for defense reactions and its efferent pathway to the brain stem. J Physiol 165:160–173, 1963.

    PubMed  Google Scholar 

  93. Djojosugito, A.M., Folkow, B., Klystra, P., Lisander, B., Tuttle, R.S.: Differentiated interaction between the hypothalamic defense reaction and baroreceptor reflexes. I. Effects on heart rate and regional flow resistance. Acta Physiol Scand 78:376–383, 1970.

    Article  PubMed  Google Scholar 

  94. Klystra, P.H., Lisander, B.: Differential interaction between the hypothalamic defense area and baroreceptor reflexes. II. Effects on aortic blood flow as related to work load on the left ventricle. Acta Physiol Scand 78:386–392, 1970.

    Article  Google Scholar 

  95. Adair, J.R., Manning, J.W.: Hypothalamic modulation of baroreceptor afferent unit activity. Am J Physiol 229:1357–1364, 1975.

    PubMed  Google Scholar 

  96. McAllen, R.M.: Inhibition of the baroreceptor input to the medulla by stimulation of the hypothalamic defence area. J Physiol 256:45P–46P, 1976.

    Google Scholar 

  97. Pribram, K.H., McGuinness, D.: Arousal, activation and effort in the control of attention. Psychol Rev 82:116–149, 1975.

    Article  PubMed  Google Scholar 

  98. Abrahams, V.C., Hilton, S.M., Zbrozyna, A.: Active vasodilation produced by stimulation of the brain stem: its significance in the defense reactions. J Physiol 154:491–513, 1960.

    PubMed  Google Scholar 

  99. Gebber, G.L., Taylor, D.G., Weaver, L.C.: Electrophysiological studies on organization of central vasopressor pathways. Am J Physiol 224:470–481, 1973.

    PubMed  Google Scholar 

  100. Thomas, M.R., Ulrichsen, R.F., Calaresu, F.R.: Function of the lateral reticular nucleus in central cardiovascular regulation in the cat. Am J Physiol 232:H157–H166, 1977.

    PubMed  Google Scholar 

  101. Horeyseck, G., Janig, W., Kirchner, F., Thamer, V.: Activation and inhibition of muscle and cutaneous postganglionic neurones to hindlimb during hypothalamically induced vasoconstriction and atropine-sensitive vasodilation. Pfluegers Arch 361:231–240, 1976.

    Article  Google Scholar 

  102. Ross, R., Glomset, J.A.: The pathogenesis of atherosclerosis. N Engl J Med 295:369–377, 1976.

    Article  PubMed  Google Scholar 

  103. Forsyth, R.P., Harris, R.E.: Circulatory changes during stressful stimuli in rhesus monkeys. Circ Res 26, 27 (Suppl. 1): 13–20, 1970.

    Google Scholar 

  104. Lund-Johansen, P.: Hemodynamic alterations in essential hypertension. In Hypertension: Mechanisms and Management (Onesti, G., Kim, K. E., Moyer, J.H., eds.) New York: Grune & Stratton, 1973.

    Google Scholar 

  105. Okamoto, K., & Aoki, K.: Development of a strain of spontaneously hypertensive mts.Jpn Circ J 27:282–288, 1963.

    Article  Google Scholar 

  106. Lais, L.T., Brody, M.J.: Pathogenesis of hypertension in spontaneously hypertensive rats. In New Antihypertensive Drugs (Scriabine, A., Sweet, C.S., eds.) New York: Spectrum, 1977.

    Google Scholar 

  107. Mendlowitz, M.: Vascular reactivity in systemic arterial hypertension. In Hypertension: Mechanisms and Management (Onesti, G., Kim, K.E., Moyer, J.H., eds.) New York: Grune & Stratton, 1973.

    Google Scholar 

  108. Gordon, T., Verter, J.: Serum cholesterol, systolic blood pressure and Framingham relative weight as discriminators of cardiovascular disease. In The Framingham Study: An Epidemiological Investigation of Cardiovascular Disease (Kannel, W.B., Gordon, T., eds.) Washington, D.C.: U. S. Govt. Ptg. Office, 1969.

    Google Scholar 

  109. Bronte-Stewart, B., Heptinstahl, R.H.: The relationship between experimental hypertension and cholesterol-induced atheroma in rabbits. J Pathol 68:407–414, 1954.

    Article  Google Scholar 

  110. Heindel, J.J., Orci, L., Jeanrenaud, B.: Fat mobilization and its regulation by hormones and drugs in white adipose tissue. In International Encyclopedia of Pharmacology and Therapeutics. Pharmacology of Lipid Transport and Atherosclerotic Processes. (Masoro, E.J., ed.). 24, 1:175–373, Oxford: Pergamon, 1975.

    Google Scholar 

  111. Haft, J.I., Kranz, P.D., Albert, F.J., Fani, K.: Intravascular platelet aggregation in the heart induced by norepinephrine. Circulation 46:698–708, 1972.

    PubMed  Google Scholar 

  112. Kosowsky, B.D., Lown, B., Whiting, R., Guiney, T.: Occurrence of ventricular arrhythmia with exercise as compared to monitoring. Circulation 44:826–832, 1971.

    PubMed  Google Scholar 

  113. Sigler, L.H.: Emotion and arteriosclerotic heart disease. I. Electrocardiographic changes observed on the recall of past emotional disturbances. Br J Med Psychol 30:55–64, 1967.

    Article  Google Scholar 

  114. Levy, M.N.: Neural mechanisms in cardiac arrythmias. J Lab Clin Med 90:589–591, 1977.

    PubMed  Google Scholar 

  115. Yehle, A., Dauth, G., Schneiderman, N.: Correlates of heart-rate classical conditioning in curarized rabbits. J Comp Physiol Psychol 64:98–104, 1967.

    Article  PubMed  Google Scholar 

  116. Schneiderman, N.: Classical (Pavlovian) Conditioning. Morristown, N.J.: General Learning Press, 1973.

    Google Scholar 

  117. Friedman, M., Rosenman, R.H.: Type A Behavior and Your Heart. New York: Knopf, 1974.

    Google Scholar 

  118. Rosenman, R.H., Brand, R.J., Jenkins, C.D., Friedman, M., Straus, R., Wurm, M.: Coronary heart disease in the Western Collaborative Group Study: final follow-up experience of 81/2 years. JAMA 233:872–877, 1975.

    Article  PubMed  Google Scholar 

  119. Glass, D.C.: Stress, behavior patterns and coronary disease. Am Sci 65:177–187, 1977.

    PubMed  Google Scholar 

  120. Greene, W.A., Goldstein, S., Moss, A.J.: Psychosocial aspects of sudden death: a preliminary report. Arch Intern Med 129:725–731, 1972.

    Article  PubMed  Google Scholar 

  121. Glass, D.C.: Behavior Patterns, Stress, and Coronary Disease. Hillsdale, N.J., Lawrence Erlbaum Associates, 1977.

    Google Scholar 

  122. Rahe, R.H.: Stress and strain in coronary heart disease. J SC Med Assoc (Suppl.) 72:7–14, 1975.

    Google Scholar 

  123. Lund-Johansen, P.: Hemodynamic alterations in essential hypertension. In Hypertension: Mechanisms and Management (Onesti, G., Kim, K.E., Moyer, J.H., eds.). New York: Grune & Stratton, 1973.

    Google Scholar 

  124. Dahl, L.K., Heine, M., Tassinari, L.J.: Role of genetic factors in susceptibility to experimental hypertension due to chronic excess salt ingestion. Nature 194:480–482, 1962.

    Article  PubMed  Google Scholar 

  125. Friedman, M., Rosenman, R.H.: Association of specific overt behavior pattern with blood and cardiovascular findings. Blood cholesterol level, blood clotting time, incidence of arcus senilis, and clinical coronary artery disease. JAMA 169:1286–1296, 1959.

    Article  Google Scholar 

  126. Gunn, C.G., Friedman, M., Byers, S.D.: Effect of chronic hypothalamic stimulation upon cholesterol-induced atherosclerosis in the rabbit. J Clin Invest 39:1963–1972, 1960.

    Article  PubMed  Google Scholar 

  127. Raab, W.: Cardiotoxic biochemical effects of emotional-environmental stressors— fundamentals of psychocardiology. In Society, Stress and Disease (Levi, L., ed.). London, Oxford, 1971.

    Google Scholar 

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Schneiderman, N. (1978). Animal Models Relating Behavioral Stress and Cardiovascular Pathology. In: Dembroski, T.M., Weiss, S.M., Shields, J.L., Haynes, S.G., Feinleib, M. (eds) Coronary-Prone Behavior. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-86007-2_13

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  • DOI: https://doi.org/10.1007/978-3-642-86007-2_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-86009-6

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